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Sodium orthovanadate, a powerful vasoconstrictor in the gills of the common eel, Anguilla anguilla

Published online by Cambridge University Press:  11 May 2009

M. V. Bell ,
K. F. Kelly  and
J. R. Sargent
M. V. Bell
Affiliation:
Institute of Marine Biochemistry, Aberdeen, Scotland
K. F. Kelly
Affiliation:
Institute of Marine Biochemistry, Aberdeen, Scotland
J. R. Sargent
Affiliation:
Institute of Marine Biochemistry, Aberdeen, Scotland
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Extract

Sodium orthovanadate added internally is a powerful vasoconstrictor in perfused, irrigated gills of Anguilla anguilla. The anion is active at concentrations as low as 10-7 M and its action is antagonized by β-adrenergic vasodilators such as adrenaline and isoprenaline. These effects are discussed in terms of the known mode of action of vanadate as an inhibitor of (Na+ + K+)-dependent ATPase. The biological and pharmacological effects of naturally occurring vanadate are assessed.

Type
Research Article
Information
Journal of the Marine Biological Association of the United Kingdom , Volume 59 , Issue 2 , May 1979 , pp. 429 - 435
Copyright
Copyright © Marine Biological Association of the United Kingdom 1979

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