S.-Y. Cheng, P. Li and S.-T. Yau proved comparison theorems for the volume of extrinsic balls in minimal submanifolds of space forms. These results were extended by S. Markvorsen for minimal submanifolds of a riemannian manifold with just an upper bound on the sectional curvature. In the paper an isoperimetric inequality for extrinsic balls in minimal submanifolds of a riemannian manifold N with sectional curvatures bounded from above by a non-positive constant is found. As a corollary of this result an alternative proof is obtained of the comparison for the volume of extrinsic balls stated by the preceding authors, but now the equality case is characterized when the upper bound for the sectional curvatures of the ambient manifold is strictly negative. Finally, when the sectional curvatures of N are bounded from above for any constant (positive or negative), it is proved that the ∞-isoperimetric quotient of the extrinsic balls is bounded from below by the mean curvature of the geodesic spheres in the m-dimensional real space forms.