Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-22T21:34:40.187Z Has data issue: false hasContentIssue false
  • English
  • Français

White Matter Microstructural Integrity and Executive Function in Parkinson's Disease

Published online by Cambridge University Press:  15 January 2013

Catherine Gallagher ,
Brian Bell ,
Barbara Bendlin ,
Matthew Palotti ,
Ozioma Okonkwo ,
Aparna Sodhi ,
Rachel Wong ,
Laura Buyan-Dent ,
Sterling Johnson  and
Auriel Wilette
...Show all authors
Catherine Gallagher*
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Brian Bell
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Barbara Bendlin
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Matthew Palotti
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Ozioma Okonkwo
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Aparna Sodhi
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Rachel Wong
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Laura Buyan-Dent
Affiliation:
Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Sterling Johnson
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Auriel Wilette
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Sandra Harding
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Nancy Ninman
Affiliation:
Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Erik Kastman
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Andrew Alexander
Affiliation:
Waisman Center Laboratory for Brain Imaging and Behavior, Madison, Wisconsin Department of Medical Physics, UWSMPH, Madison, Wisconsin
*
Correspondence and reprint requests to: Catherine Gallagher, 7211 MFCB, 1685 Highland Avenue, Madison, WI 53705-2281. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Recent studies suggest that white matter abnormalities contribute to both motor and non-motor symptoms of Parkinson's disease. The present study was designed to investigate the degree to which diffusion tensor magnetic resonance imaging (DTI) indices are related to executive function in Parkinson's patients. We used tract-based spatial statistics to compare DTI data from 15 patients to 15 healthy, age- and education-matched controls. We then extracted mean values of fractional anisotropy (FA) and mean diffusivity (MD) within an a priori frontal mask. Executive function composite Z scores were regressed against these DTI indices, age, and total intracranial volume. In Parkinson's patients, FA was related to executive composite scores, and both indices were related to Stroop interference scores. We conclude that white matter microstructural abnormalities contribute to cognitive deficits in Parkinson's disease. Further work is needed to determine whether these white matter changes reflect the pathological process or a clinically important comorbidity. (JINS, 2013, 19, 1–6)

Keywords

idiopathic Parkinson diseasediffusion magnetic resonance imagingexecutive functioncognitionaging
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 3 , March 2013 , pp. 349 - 354
Copyright
Copyright © The International Neuropsychological Society 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alexander, G.E., DeLong, M.R., Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381. doi:10.1146/annurev.ne.09.030186.002041CrossRefGoogle ScholarPubMed
Benton, A., Hamsher, D., Sivan, A. (1983). Multilingual Aphasia Examination, 3rd ed. Iowa City: AJA Associates.Google Scholar
Bohnen, N.I., Albin, R.L. (2011). White matter lesions in Parkinson disease. Nature Reviews Neurology, 7(4), 229–236. doi:10.1038/nrneurol.2011.21CrossRefGoogle ScholarPubMed
Braak, H., Del Tredici, K., Bratzke, H., Hamm-Clement, J., Sandmann-Keil, D., Rub, U. (2002). Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). Journal of Neurology, 249(Suppl 3), III/1–5.CrossRefGoogle ScholarPubMed
de la Monte, S.M., Wells, S.E., Hedley-Whyte, T., Growdon, J.H. (1989). Neuropathological distinction between Parkinson's dementia and Parkinson's plus Alzheimer's disease. Annals of Neurology, 26(3), 309–320. doi:10.1002/ana.410260302CrossRefGoogle ScholarPubMed
Gibb, W.R., Lees, A.J. (1988). The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry, 51(6), 745–752.CrossRefGoogle Scholar
Golden, C.J. (1975). The measurement of creativity by the Stroop Color and Word Test. Journal of Personality Assessment, 39(5), 502–506. doi:10.1207/s15327752jpa3905_9CrossRefGoogle ScholarPubMed
Hoehn, M.M., Yahr, M.D. (1967). Parkinsonism: Onset, progression and mortality. Neurology, 17(5), 427–442.CrossRefGoogle ScholarPubMed
Matsui, H., Nishinaka, K., Oda, M., Niikawa, H., Komatsu, K., Kubori, T., Udaka, F. (2007). Wisconsin Card Sorting Test in Parkinson's disease: Diffusion tensor imaging. Acta Neurologica Scandinavica, 116(2), 108–112. doi:10.1111/j.1600-0404.2006.00795.xCrossRefGoogle ScholarPubMed
Muslimovic, D., Post, B., Speelman, J.D., Schmand, B. (2005). Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology, 65(8), 1239–1245. doi:10.1212/01.wnl.0000180516.69442.95CrossRefGoogle ScholarPubMed
Oishi, K., Faria, A., Van Zijl, P.C.M., Mori, S. (2011). MRI atlas of human white matter (2nd ed.). London, UK: Elsevier Academic Press.Google Scholar
Paolo, A.M., Axelrod, B.N., Troster, A.I., Blackwell, K.T., Koller, W.C. (1996). Utility of a Wisconsin Card Sorting Test short form in persons with Alzheimer's and Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 18(6), 892–897. doi:10.1080/01688639608408310CrossRefGoogle ScholarPubMed
Rae, C.L., Correia, M.M., Altena, E., Hughes, L.E., Barker, R.A., Rowe, J.B. (2012). White matter pathology in Parkinson's disease: The effect of imaging protocol differences and relevance to executive function. Neuroimage, 62(3), 1675–1684. doi:10.1016/j.neuroimage.2012.06.012CrossRefGoogle ScholarPubMed
Reitan, R. (1992). Trail Making Test. Manual for administration and scoring. Tucson, AZ: Reitan Neuropsychological Laboratory.Google Scholar
Sager, M.A., Hermann, B., La Rue, A. (2005). Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. Journal of Geriatric Psychiatry and Neurology, 18(4), 245–249. doi:10.1177/0891988705281882CrossRefGoogle ScholarPubMed
Scheltens, P., Barkhof, F., Leys, D., Pruvo, J.P., Nauta, J.J., Vermersch, P., Valk, J. (1993). A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. Journal of the Neurological Sciences, 114(1), 7–12.CrossRefGoogle ScholarPubMed
Stuss, D.T., Floden, D., Alexander, M.P., Levine, B., Katz, D. (2001). Stroop performance in focal lesion patients: Dissociation of processes and frontal lobe lesion location. Neuropsychologia, 39(8), 771–786.CrossRefGoogle ScholarPubMed
Smith, S.M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T.E., Mackay, C.E., Behrens, T.E. (2006). Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. Neuroimage, 31(4), 1487–1505. doi:10.1016/j.neuroimage.2006.02.024CrossRefGoogle ScholarPubMed
Smith, S.M., Nichols, T.E. (2009). Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage, 44(1), 83–98. doi:10.1016/j.neuroimage.2008.03.061CrossRefGoogle ScholarPubMed
Zhan, W., Kang, G.A., Glass, G.A., Zhang, Y., Shirley, C., Millin, R., Schuff, N. (2012). Regional alterations of brain microstructure in parkinson's disease using diffusion tensor imaging. Movement Disorders, 27(1), 90–97. doi:10.1002/mds.23917CrossRefGoogle ScholarPubMed