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What do Alzheimer's disease patients know about animals? It depends on task structure and presentation format

Published online by Cambridge University Press:  11 January 2002

JILL B. RICH ,
NORMAN W. PARK ,
STEPHEN DOPKINS,  and
JASON BRANDT
JILL B. RICH
Affiliation:
Department of Psychology, York University and Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
NORMAN W. PARK
Affiliation:
Kunin-Lunenfeld Applied Research Unit and Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
STEPHEN DOPKINS,
Affiliation:
Department of Psychology, George Washington University, Washington, DC
JASON BRANDT
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD
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Abstract

Deficits on tasks requiring semantic memory in Alzheimer's disease (AD) may be due to storage loss, a retrieval deficit, or both. To address this question, we administered multiple tasks involving 9 exemplars of the category “animals,” presented as both words and pictures, to 12 AD patients and 12 nondemented individuals. Participants made semantic judgments by class (sorting task), similarity (triadic comparison task), and dimensional attributes (ordering task). Relative to control participants, AD patients were impaired on an unstructured sorting task, but did not differ on a constrained sorting task. On the triadic comparison task, the patients were as likely to make judgments based on size as domesticity attributes, whereas control participants made judgments based primarily on domesticity. The patients' judgments were also less consistent across tasks than those of control participants. On the ordering tasks, performance was generally comparable between groups with pictures but not words, suggesting that pictures enable AD patients to access information from semantic memory that is less accessible with lexical stimuli. These results suggest that AD patients' semantic judgments are impaired when the retrieval context is unstructured, but perform normally under supportive retrieval conditions. (JINS, 2002, 8, 83–94.)

Keywords

Alzheimer's diseaseSemantic memoryFormat effects
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 8 , Issue 1 , January 2002 , pp. 83 - 94
Copyright
© 2002 The International Neuropsychological Society

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References

REFERENCES

Abeysinghe, S.C., Bayles, K.A., & Trosset, M.W. ( 1990). Semantic memory deterioration in Alzheimer's subjects: Evidence from word association, definition, and associate ranking tasks. Journal of Speech and Hearing Research, 33, 574– 582.CrossRefGoogle Scholar
Barr, A. & Brandt, J. ( 1996). Word-list generation deficits in dementia. Journal of Clinical and Experimental Neuropsychology, 18, 810– 822.CrossRefGoogle Scholar
Bayles, K.A. & Kaszniak, A.W. ( 1987). Communication and cognition in normal aging and dementia. Boston: College-Hill Press.
Bayles, K.A. & Tomoeda, C.K. ( 1983). Confrontation naming impairment in dementia. Brain and Language, 19, 98– 114.CrossRefGoogle Scholar
Bayles, K.A., Tomoeda, C.K., Kaszniak, A.W., & Trosset, M.W. ( 1991). Alzheimer's disease effects on semantic memory: Loss of structure or impaired processing? Journal of Cognitive Neuroscience, 3, 166– 182.Google Scholar
Bonilla, J.L. & Johnson, M.K. ( 1995). Semantic space in Alzheimer's disease patients. Neuropsychology, 9, 345– 353.CrossRefGoogle Scholar
Brandt, J. & Butters, N. ( 1996). Neuropsychological characteristics of Huntington's disease. In I. Grant & K.M. Adams (Eds.), Neuropsychological assessment of neuropsychiatric disorders ( 2nd ed., pp. 312– 341). New York: Oxford University Press.
Brandt, J. & Rich, J.B. ( 1995). Memory disorders in the dementias. In A.D. Baddeley, B.A. Wilson, & F.N. Watts (Eds.), Handbook of memory disorders (pp. 243– 270). Chichester, UK: Wiley.
Caramazza, A., Hillis, A.E., Rapp, B., & Romani, C. ( 1990). The multiple semantics hypothesis: Multiple confusions? Cognitive Neuropsychology, 8, 161– 190.Google Scholar
Chan, A.S., Butters, N., Paulsen, J.S., Salmon, D.P., Swenson, M.R., & Maloney, L.T. ( 1993a). An assessment of the semantic network in patients with Alzheimer's disease. Journal of Cognitive Neuroscience, 5, 254– 261.Google Scholar
Chan, A.S., Butters, N., & Salmon, D.P. ( 1997). The deterioration of semantic networks in patients with Alzheimer's disease: A cross-sectional study, Neuropsychologia, 35, 241– 248.Google Scholar
Chan, A.S., Butters, N., Salmon, D.P., Johnson, S.A., Paulsen, J.S., & Swenson, M.R. ( 1995a). Comparison of the semantic networks in patients with dementia and amnesia. Neuropsychology, 9, 177– 186.Google Scholar
Chan, A.S., Butters, N., Salmon, D.P., & McGuire, K.A. ( 1993b). Dimensionality and clustering in the semantic network of patients with Alzheimer's disease, Psychology and Aging, 8, 411– 419.Google Scholar
Chan, A.S., Salmon, D.P., & Butters, N. ( 1995b). Semantic network abnormality predicts rate of cognitive decline in patients with probable Alzheimer's disease. Journal of the International Neuropsychological Society, 1, 297– 303.Google Scholar
Chertkow, H. & Bub, D. ( 1990). Semantic memory loss in dementia of Alzheimer's type. Brain, 113, 397– 417.CrossRefGoogle Scholar
Chertkow, H., Bub, D., & Caplan, D. ( 1992). Constraining theories of semantic memory processing: Evidence from dementia. Cognitive Neuropsychology, 9, 327– 365.CrossRefGoogle Scholar
Craik, F.I.M., Byrd, M., & Swanson, J.M. ( 1987). Patterns of memory loss in three elderly samples. Psychology and Aging, 2, 79– 86.CrossRefGoogle Scholar
Eustache, F., Cox, C., Brandt, J., Lechevalier, B., & Pons, L. ( 1990). Word-association responses and severity of dementia in Alzheimer disease, Psychological Reports, 66, 1315– 1322.Google Scholar
Hillis, A.E., Rapp, B., & Caramazza, A. ( 1995). Constraining claims about theories of semantic memory: More on unitary versus multiple semantics. Cognitive Neuropsychology, 12, 175– 186.CrossRefGoogle Scholar
Hodges, J.R., Salmon, D.P., & Butters, N. ( 1992). Semantic memory impairment in Alzheimer's disease: Failure of access or degraded knowledge? Neuropsychologia, 30, 301– 314.Google Scholar
Huff, F.J., Corkin, S., & Growdon, J.H. ( 1986). Semantic impairment and anomia in Alzheimer's disease. Brain and Language, 28, 235– 249.CrossRefGoogle Scholar
Jacoby, L.L. ( 1991). A process dissociation framework: Separating automatic from intentional uses of memory. Journal of Memory and Language, 30, 513– 541.CrossRefGoogle Scholar
Johnson, M.K., Hermann, A.M., & Bonilla, J.L. ( 1995). Semantic relations and Alzheimer's disease: Typicality and direction of testing. Neuropsychology, 9, 529– 536.CrossRefGoogle Scholar
Kruskal, J. & Wish, M. ( 1978). Multidimensional scaling. Beverly Hills, CA: Sage.CrossRef
Lauro-Grotto, R., Piccini, C., & Shallice, T. ( 1997). Modality-specific operations in semantic dementia. Cortex, 33, 593– 622.CrossRefGoogle Scholar
Martin, A. ( 1992). Degraded knowledge representations in patients with Alzheimer's disease: Implications for models of semantic and repetition priming. In L.R. Squire & N. Butters (Eds.), Neuropsychology of memory ( 2nd ed., pp. 220– 232). New York: Guilford Press.
Martin, A. & Fedio, P. ( 1983). Word production and comprehension in Alzheimer's disease: The breakdown of semantic knowledge. Brain and Language, 19, 124– 141.CrossRefGoogle Scholar
Mattis, S. ( 1988). Dementia Rating Scale. Odessa, FL: Psychological Assessment Resources.
McCarthy, R.A. & Warrington, E.K. ( 1988). Evidence for modality-specific meaning systems in the brain. Nature, 334, 428– 430.CrossRefGoogle Scholar
McCarthy, R.A. & Warrington, E.K. ( 1990). Cognitive neuropsychology. New York: Academic Press.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. ( 1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939– 944.CrossRefGoogle Scholar
Menard, M.T., Kosslyn, S.M., Thompson, W.L., & Alpert, N.M. ( 1996). Encoding words and pictures: A positron emission tomography study. Neuropsychologia, 34, 185– 194.CrossRefGoogle Scholar
Monsch, A.U., Bondi, M.W., Paulsen, J.S., Brugger, P., & Butters, N. ( 1994). A comparison of category and letter fluency in Alzheimer's disease and Huntington's disease. Neuropsychology, 8, 25– 30.CrossRefGoogle Scholar
Moscovitch, M. ( 1992). Memory and working-with-memory: A component process model based on modules and central systems. Journal of Cognitive Neuroscience, 4, 257– 267.CrossRefGoogle Scholar
Nebes, R.D. ( 1989). Semantic memory in Alzheimer's disease. Psychological Bulletin, 106, 377– 394.CrossRefGoogle Scholar
Nebes, R.D. ( 1992). Semantic memory dysfunction in Alzheimer's disease: Disruption of semantic knowledge or information-processing limitation? In L.R. Squire & N. Butters (Eds.), Neuropsychology of memory ( 2nd ed., pp. 233– 240). New York: Guilford Press.
Ober, B.A. & Shenaut, G.K. ( 1995). Semantic priming in Alzheimer's disease: Meta-analysis and theoretical evaluation. In P. Allen & T.R. Bashore (Eds.) Age differences in word and language processing. Amsterdam: Elsevier Science.
Ober, B.A. & Shenaut, G.K. ( 1999). Well-organized conceptual domains in Alzheimer's disease. Journal of the International Neuropsychological Society, 5, 676– 684.CrossRefGoogle Scholar
Park, N.W. & Ingles, J.L. ( 2001). Effectiveness of attention rehabilitation after an acquired brain injury: A meta-analysis. Neuropsychology, 15, 199– 210.CrossRefGoogle Scholar
Perani, D., Schnur, T., Tettamanti, M., Gorno-Tempini, M., Cappa, S.F., & Fazio, F. ( 1999). Word and picture matching: A PET study of semantic category effects. Neuropsychologia, 37, 293– 306.CrossRefGoogle Scholar
Riddoch, M.J., Humphreys, G.W., Coltheart, M., & Funnell, E. ( 1988). Semantic systems or system? Neuropsychological evidence re-examined. Cognitive Neuropsychology, 5, 3– 25.CrossRefGoogle Scholar
Salmon, D.P., Heindel, W.C., & Lange, K.L. ( 1999). Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer's disease: Implications for the integrity of semantic memory. Journal of the International Neuropsychological Society, 5, 692– 703.CrossRefGoogle Scholar
Shallice, T. ( 1988). From neuropsychology to mental structure. Cambridge, UK: Cambridge University Press.CrossRef
Snodgrass, J.G. & Vanderwart, M. ( 1980). A standardized set of 260 pictures: Norms for name agreement, image agreement, familiarity, and visual complexity. Journal of Experimental Psychology: Human Learning and Memory, 6, 174– 215.CrossRefGoogle Scholar
Tröster, A.I., Salmon, D.P., McCullough, D., & Butters, N. ( 1989). A comparison of category fluency deficits associated with Alzheimer's and Huntington's disease. Brain and Language, 37, 500– 513.CrossRefGoogle Scholar
Tulving, E. ( 1972). Episodic and semantic memory. In E. Tulving & W. Donaldson (Eds.), Organization of memory (pp. 381– 403). New York: Academic Press.
Warrington, E.K. & Shallice, T. ( 1984). Category specific semantic impairments. Brain, 107, 829– 854.CrossRefGoogle Scholar