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Volume of the Human Septal Forebrain Region Is a Predictor of Source Memory Accuracy

Published online by Cambridge University Press:  09 December 2011

Tracy Butler ,
Karen Blackmon ,
Laszlo Zaborszky ,
Xiuyuan Wang ,
Jonathan DuBois ,
Chad Carlson ,
William B. Barr ,
Jacqueline French ,
Orrin Devinsky  and
Ruben Kuzniecky
...Show all authors
Tracy Butler*
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Karen Blackmon
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Laszlo Zaborszky
Affiliation:
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey
Xiuyuan Wang
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Jonathan DuBois
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Chad Carlson
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
William B. Barr
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Jacqueline French
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Orrin Devinsky
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Ruben Kuzniecky
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York
Eric Halgren
Affiliation:
Multimodal Imaging Laboratory, University of California, San Diego, California
Thomas Thesen
Affiliation:
Comprehensive Epilepsy Center, Department of Neurology, New York University Medical Center, New York, New York Multimodal Imaging Laboratory, University of California, San Diego, California
*
Correspondence and reprint requests to: Tracy Butler, NYU Comprehensive Epilepsy Center, Department of Neurology, 223 East 34th Street New York, New York 10016. E-mail: [email protected]
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Abstract

Septal nuclei, components of basal forebrain, are strongly and reciprocally connected with hippocampus, and have been shown in animals to play a critical role in memory. In humans, the septal forebrain has received little attention. To examine the role of human septal forebrain in memory, we acquired high-resolution magnetic resonance imaging scans from 25 healthy subjects and calculated septal forebrain volume using recently developed probabilistic cytoarchitectonic maps. We indexed memory with the California Verbal Learning Test-II. Linear regression showed that bilateral septal forebrain volume was a significant positive predictor of recognition memory accuracy. More specifically, larger septal forebrain volume was associated with the ability to recall item source/context accuracy. Results indicate specific involvement of septal forebrain in human source memory, and recall the need for additional research into the role of septal nuclei in memory and other impairments associated with human diseases. (JINS, 2012, 18, 157–161)

Keywords

Septal nucleiBasal forebrainEpisodic memory CVLTMRIMorphometryParahippocampal gyrus
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 1 , January 2012 , pp. 157 - 161
Copyright
Copyright © The International Neuropsychological Society 2011

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Supplementary material: PDF

Butler Supplementary Table

Supplementary Table 1. Neuropsychological test data for California Verbal Learning Test-II and Boston Naming Test

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