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The UCLA Longitudinal Study of Neurocognitive Outcomes Following Mild Pediatric Traumatic Brain Injury

Published online by Cambridge University Press:  04 August 2011

Talin Babikian ,
Paul Satz ,
Ken Zaucha ,
Roger Light ,
Richard S. Lewis  and
Robert F. Asarnow
Talin Babikian*
Affiliation:
Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California
Paul Satz
Affiliation:
Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California
Ken Zaucha
Affiliation:
Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California
Roger Light
Affiliation:
Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California Centinela Freeman Regional Medical Center, Inglewood, California
Richard S. Lewis
Affiliation:
Departments of Neuroscience and Psychology, Pomona College, Claremont, California
Robert F. Asarnow
Affiliation:
Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California Department of Psychology, University of California at Los Angeles, Los Angeles, California
*
Correspondence and reprint requests to: Talin Babikian, PhD, Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Room C8-746, Los Angeles, CA 90024. E-mail: [email protected]
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Abstract

Comprehensive reviews of neurocognitive outcomes following mild, uncomplicated traumatic brain injury (TBI) in children have shown minimal effects on neurocognition, especially in methodologically rigorous studies. In this study, we report longitudinal (1, 6, and 12 months post injury) results in four domains of neurocognitive functioning in a large sample of children with mild TBI (n = 124, ages 8–17 at injury) relative to two demographically matched control groups (other injury: n = 94 and non-injury: n = 106). After accounting for age and parental education, significant main effects of group were observed on 7 of the 10 neurocognitive tests. However, these differences were not unique to the TBI sample but were found between both the TBI and other injury groups relative to the non-injured group, suggesting a general injury effect. Effects were primarily within the domains measuring memory, psychomotor processing speed, and language. This is the largest longitudinal study to date of neurocognitive outcomes at discrete time points in pediatric mild TBI. When controlling for pre-injury factors, there is no evidence of long-term neurocognitive impairment in this group relative to another injury control group. The importance of longitudinal analyses and use of appropriate control groups are discussed in the context of evaluating the effects of mild TBI on cognition. (JINS, 2011, 17, 886–895)

Keywords

Traumatic brain injuryChild and adolescentCognitiveMild TBIConcussionLongitudinal study
Type
Regular Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 5 , September 2011 , pp. 886 - 895
Copyright
Copyright © The International Neuropsychological Society 2011

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Footnotes

†

Now deceased; Dr. Satz played a key role in the development of this project.

References

Achenbach, T.M. (1991). Child behavior checklist. Burlington, VT: Achenbach System of Empirically Based Assessment.Google Scholar
Anderson, V., Catroppa, C., Morse, S., Haritou, F., Rosenfeld, J. (2001). Outcome from mild head injury in young children: A prospective study. Journal of Clinical and Experimental Neuropsychology, 23(6), 705–717.CrossRefGoogle ScholarPubMed
Asarnow, R.F., Satz, P., Light, R., Lewis, R., Neumann, E. (1991). Behavior problems and adaptive functioning in children with mild and severe closed head injury. Journal of Pediatric Psychology, 16(5), 543–555.CrossRefGoogle ScholarPubMed
Asarnow, R.F., Satz, P., Light, R., Zaucha, K., Lewis, R., McCleary, C. (1995). The UCLA study of mild closed head injury in children and adolescents. In S. Broman & M. E. Michel (Eds.), Traumatic brain injury in children (pp. 117–146). New York: Oxford University Press.Google Scholar
Babikian, T., Asarnow, R. (2009). Neurocognitive outcomes and recovery after pediatric TBI: Meta-analytic review of the literature. Neuropsychology, 23(3), 283–296.CrossRefGoogle ScholarPubMed
Barlow, K.M., Crawford, S., Stevenson, A., Sandhu, S.S., Belanger, F., Dewey, D. (2010). Epidemiology of postconcussion syndrome in pediatric mild traumatic brain injury. Pediatrics, 126(2), e374–e381.CrossRefGoogle ScholarPubMed
Belanger, H.G., Vanderploeg, R.D. (2005). The neuropsychological impact of sports-related concussion: A meta-analysis. Journal of the International Neuropsychological Society, 11(4), 345–357.CrossRefGoogle ScholarPubMed
Bijur, P.E., Haslum, M., Golding, J. (1990). Cognitive and behavioral sequelae of mild head injury in children. Pediatrics, 86(3), 337–344.CrossRefGoogle ScholarPubMed
Bruce, B., Kirkland, S., Waschbusch, D. (2007). The relationship between childhood behaviour disorders and unintentional injury events. Paediatric Child Health, 12(9), 749–754.CrossRefGoogle ScholarPubMed
Catale, C., Marique, P., Closset, A., Meulemans, T. (2009). Attentional and executive functioning following mild traumatic brain injury in children using the Test for Attentional Performance (TAP) battery. Journal of Clinical and Experimental Neuropsychology, 31(3), 331–338.CrossRefGoogle ScholarPubMed
Cattell, R.B. (1963). The theory of fluid and crystallized intelligence: A critical experiment. Journal of Educational Psychology, 54(1), 1–22.CrossRefGoogle Scholar
Dunn, L.M., Dunn, L.M. (1981). Peabody Picture Vocabulary Test—revised manual. Circle Pines, MN: American Guidance Service.Google Scholar
Durkin, M.S., Davidson, L.L., Kuhn, L., O'Connor, P., Barlow, B. (1994). Low-income neighborhoods and the risk of severe pediatric injury: A small-area analysis in northern Manhattan. American Journal of Public Health, 84(4), 587–592.CrossRefGoogle ScholarPubMed
Fay, T.B., Yeates, K.O., Wade, S.L., Drotar, D., Stancin, T., Taylor, H.G. (2009). Predicting longitudinal patterns of functional deficits in children with traumatic brain injury. Neuropsychology, 23(3), 271–282.CrossRefGoogle ScholarPubMed
Ganesalingam, K., Yeates, K.O., Ginn, M.S., Taylor, H.G., Dietrich, A., Nuss, K., Wright, M. (2008). Family burden and parental distress following mild traumatic brain injury in children and its relationship to post-concussive symptoms. Journal of Pediatric Psychology, 33(6), 621–629.CrossRefGoogle ScholarPubMed
Golden, J.C. (1976). Identification of brain disorders by the Stroop Color and Word Test. Journal of Clinical Psychology, 32, 654–658.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Greenspan, L., McLellan, B.A., Greig, H. (1985). Abbreviated Injury Scale and Injury Severity Score: A scoring chart. Journal of Trauma, 25(1), 60–64.CrossRefGoogle ScholarPubMed
Kirkwood, M.W., Yeates, K.O., Taylor, H.G., Randolph, C., McCrea, M., Anderson, V.A. (2008). Management of pediatric mild traumatic brain injury: A neuropsychological review from injury through recovery. Clinical Neuropsychology, 22(5), 769–800.CrossRefGoogle ScholarPubMed
Kogan, M.D., Overpeck, M.D., Fingerhut, L.A. (1995). Medically attended nonfatal injuries among preschool-age children: National estimates. American Journal of Preventive Medicine, 11(2), 99–104.CrossRefGoogle ScholarPubMed
Lee, L.K. (2007). Controversies in the sequelae of pediatric mild traumatic brain injury. Pediatric Emergency Care, 23(8), 580–583; quiz 584–586.CrossRefGoogle ScholarPubMed
Maillard-Wermelinger, A., Yeates, K.O., Taylor, H.G., Rusin, J., Bangert, B., Dietrich, A., Wright, M. (2009). Mild traumatic brain injury and executive functions in school-aged children. Developmental Neurorehabilitation, 12(5), 330–341.CrossRefGoogle ScholarPubMed
Nuechterlein, K.H. (1983). Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Clinical and Abnormal Psychology, 92, 4.CrossRefGoogle ScholarPubMed
Petersen, C., Scherwath, A., Fink, J., Koch, U. (2008). Health-related quality of life and psychosocial consequences after mild traumatic brain injury in children and adolescents. Brain Injury, 22(3), 215–221.CrossRefGoogle ScholarPubMed
Ramsay, L.J., Moreton, G., Gorman, D.R., Blake, E., Goh, D., Elton, R.A., Beattie, T.F. (2003). Unintentional home injury in preschool-aged children: Looking for the key--An exploration of the inter-relationship and relative importance of potential risk factors. Public Health, 117(6), 404–411.CrossRefGoogle ScholarPubMed
Reitan, R.M., Wolfson, D. (1985). The Halstead-Reitan Neuropsychological Test Battery. Tucson, AZ: Neuropsychology Press.Google Scholar
Russell, E.W. (1980). Fluid and crystallized intelligence: Effects of diffuse brain damage on the WAIS. Perceptual Motor Skills, 51(1), 121–122.CrossRefGoogle ScholarPubMed
Satz, P., D'Elia, L. (1989). The Pin Test Professional Manual. Odessa, FL: Psychological Assessment Resources.Google Scholar
Satz, P., Zaucha, K., McCleary, C., Light, R., Asarnow, R., Becker, D. (1997). Mild head injury in children and adolescents: A review of studies (1970-1995). Psychological Bulletin, 122(2), 107–131.CrossRefGoogle ScholarPubMed
Schretlen, D.J., Shapiro, A.M. (2003). A quantitative review of the effects of traumatic brain injury on cognitive functioning. International Review of Psychiatry, 15(4), 341–349.CrossRefGoogle ScholarPubMed
Schwebel, D.C., Gaines, J. (2007). Pediatric unintentional injury: Behavioral risk factors and implications for prevention. Journal of Developmental and Behavioral Pediatrics, 28(3), 245–254.CrossRefGoogle ScholarPubMed
Smith, A. (1968). The Symbol Digit Modalities test: A neuropsychologic test for learning and other cerebral disorders. Journal of Learning Disorders, 3, 83–91.Google Scholar
Wickens, D. (1970). Encoding categorized words: An empirical approach to memory. Psychological Review, 77, 1–15.CrossRefGoogle Scholar
Wrightson, P., McGinn, V., Gronwall, D. (1995). Mild head injury in preschool children: Evidence that it can be associated with a persisting cognitive defect. Journal of Neurology, Neurosurgery, and Psychiatry, 59(4), 375–380.CrossRefGoogle ScholarPubMed
Yeates, K.O. (2010). Mild traumatic brain injury and postconcussive symptoms in children and adolescents. Journal of the International Neuropsychological Society, 16(6), 953–960.CrossRefGoogle ScholarPubMed
Yeates, K.O., Taylor, H.G., Drotar, D., Wade, S.L., Klein, S., Stancin, T., Schatschneider, C. (1997). Preinjury family environment as a determinant of recovery from traumatic brain injuries in school-age children. Journal of the International Neuropsychological Society, 3(6), 617–630.CrossRefGoogle ScholarPubMed
Yeates, K.O., Taylor, H.G., Rusin, J., Bangert, B., Dietrich, A., Nuss, K., Jones, B.L. (2009). Longitudinal trajectories of postconcussive symptoms in children with mild traumatic brain injuries and their relationship to acute clinical status. Pediatrics, 123(3), 735–743.CrossRefGoogle ScholarPubMed