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Story Memory Impairment Rates and Association with Hippocampal Volumes in a Memory Clinic Population

Published online by Cambridge University Press:  30 June 2021

Christina G. Wong Open the ORCID record for Christina G. Wong [Opens in a new window] ,
Sharlene L. Jeffers ,
Samantha A. Bell ,
Jessica Z.K. Caldwell ,
Sarah J. Banks  and
Justin B. Miller Open the ORCID record for Justin B. Miller [Opens in a new window]
Christina G. Wong*
Affiliation:
Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
Sharlene L. Jeffers
Affiliation:
Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
Samantha A. Bell
Affiliation:
Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
Jessica Z.K. Caldwell
Affiliation:
Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
Sarah J. Banks
Affiliation:
Department of Neurosciences and Psychiatry, University of California, San Diego, San Diego, CA, USA
Justin B. Miller
Affiliation:
Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
*
*Correspondence and reprint requests to: Christina G. Wong, PhD, Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, 888 W. Bonneville Ave, Las Vegas, NV89106, USA., Fax: 702-438-6007. E-mail: [email protected]
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Abstract

Objective:

Story memory tasks are among the most commonly used memory tests; however, research suggests they may be less sensitive to memory decline and have a weaker association with hippocampal volumes than list learning tasks. To examine its utility, we compared story memory to other memory tests on impairment rates and association with hippocampal volumes.

Method:

Archival records from 1617 older adults (Mage = 74.41, range = 65–93) who completed the Wechsler Memory Scale – 4th edition (WMS-IV) Logical Memory (LM), Hopkins Verbal Learning Test – Revised (HVLT-R), and Brief Visuospatial Memory Test – Revised (BVMT-R) as part of a clinical neuropsychological evaluation were reviewed. Scores >1.5 SD below age-adjusted means were considered impaired, and frequency distributions were used to examine impairment rates. A subset of participants (n = 179) had magnetic resonance imaging (MRI) data that underwent image quality assessment. Partial correlations and linear regression analyses, accounting for age, education, and total intracranial volume (TIV), examined associations between memory raw scores and hippocampal volumes.

Results:

For delayed recall, nearly half of the sample was impaired on HVLT-R (48.8%) and BVMT-R (46.1%), whereas a little more than a third was impaired on LM (35.7%). Better performance on all three measures was related to larger hippocampal volumes (r’s =. 26–.43, p’s < .001). Individually adding memory scores to regression models predicting hippocampal volumes improved the model fit for all measures.

Conclusions:

Despite findings suggesting that story memory is less sensitive to memory dysfunction, it was not differentially associated with hippocampal volumes compared to other memory measures. Results support assessing memory using different formats and modalities in older adults.

Keywords

Memory disordersNeuropsychological testsHippocampusMagnetic resonance imagingAgedAlzheimer disease
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 28 , Issue 6 , July 2022 , pp. 611 - 619
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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