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Script Generation of Activities of Daily Living in HIV-Associated Neurocognitive Disorders

Published online by Cambridge University Press:  01 June 2011

J. Cobb Scott*
Affiliation:
Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, San Diego, California Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
Steven Paul Woods
Affiliation:
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
Ofilio Vigil
Affiliation:
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
Robert K. Heaton
Affiliation:
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
Igor Grant
Affiliation:
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
Ronald J. Ellis
Affiliation:
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
Thomas D. Marcotte
Affiliation:
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, California
*
Correspondence and reprint requests to: J. Cobb Scott, Yale University Department of Psychiatry & National Center for PTSD, Clinical Neurosciences Division (151E), 950 Campbell Avenue, West Haven, CT, 06516. E-mail: [email protected]

Abstract

Script generation describes one's ability to produce complex, sequential action plans derived from mental representations of everyday activities. The aim of this study was to assess the effect of human immunodeficiency virus (HIV) infection on script generation performance. Sixty HIV+ individuals (48% of whom had HIV-associated neurocognitive disorders [HAND]) and 26 demographically comparable HIV- participants were administered a novel, standardized test of script generation, which required participants to verbally generate and organize the necessary steps for completing six daily activities. HAND participants evidenced significantly more total errors, intrusions, and script boundary errors compared to the HIV- sample, indicating difficulties inhibiting irrelevant actions and staying within the prescribed boundaries of scripts, but had adequate knowledge of the relevant actions required for each script. These findings are generally consistent with the executive dysfunction and slowing common in HAND and suggest that script generation may play a role in everyday functioning problems in HIV. (JINS, 2011, 17, 740–745)

Type
Brief Communications
Copyright
Copyright © The International Neuropsychological Society 2011

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