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Relationship between psychiatric disease and neuropsychological impairment in HIV seropositive individuals

Published online by Cambridge University Press:  26 February 2009

Barbara C. Bix ,
Guila Glosser ,
William Holmes ,
Christopher Ballas ,
Mary Meritz ,
Carol Hutelmyer  and
John Turner
Barbara C. Bix
Affiliation:
Departments of Medicine, Graduate Hospital, Philadelphia, Pennsylvania 19146
Guila Glosser
Affiliation:
Departments of Neurology, Graduate Hospital, Philadelphia, Pennsylvania 19146
William Holmes
Affiliation:
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104
Christopher Ballas
Affiliation:
Department of Medicine, Pennsylvania Hospital, Philadelphia, Pennsylvania 19104
Mary Meritz
Affiliation:
Departments of Psychiatry, Graduate Hospital, Philadelphia, Pennsylvania 19146
Carol Hutelmyer
Affiliation:
Departments of Medicine, Graduate Hospital, Philadelphia, Pennsylvania 19146
John Turner
Affiliation:
Departments of Medicine, Graduate Hospital, Philadelphia, Pennsylvania 19146
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Abstract

Neuropsychological impairment and DSM-III-R Axis I psychiatric diagnoses were evaluated in a heterogenous group of HIV seropositive individuals and seronegative individuals with similar risk factors for HIV infection. Neuropsychological and psychiatric disorders were common in the HIV seropositive group, but there were no relationships between these two aspects of neuropsychiatric dysfunction in seropositive patients. Results indicate that psychiatric disorders in HIV seropositive individuals tend to predate infection and decrease over time following knowledge of seroconversion, suggesting that they are primarily a function of psychosocial factors. Neuropsychological disorders are specific to HIV seropositive patients and tend to increase over time following seroconversion, suggesting that they are due to neurological effects of HIV-infection. (JINS, 1995, 1, 581–588.)

Keywords

Neuropsychiatric dysfunctionHIV infectionPsychiatric disease
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 1 , Issue 6 , November 1995 , pp. 581 - 588
Copyright
Copyright © The International Neuropsychological Society 1995

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