Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-25T07:14:57.496Z Has data issue: false hasContentIssue false
  • English
  • Français

Progressive decline of decision-making performances during multiple sclerosis

Published online by Cambridge University Press:  01 March 2009

SAMANTA SIMIONI ,
CHRISTIANE RUFFIEUX ,
JOERG KLEEBERG ,
LAURE BRUGGIMANN ,
RENAUD A. DU PASQUIER ,
JEAN-MARIE ANNONI  and
MYRIAM SCHLUEP
SAMANTA SIMIONI
Affiliation:
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
CHRISTIANE RUFFIEUX
Affiliation:
Department of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
JOERG KLEEBERG
Affiliation:
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
LAURE BRUGGIMANN
Affiliation:
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
RENAUD A. DU PASQUIER
Affiliation:
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland Department of Immunology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
JEAN-MARIE ANNONI
Affiliation:
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland Department of Neurology, Geneva University Hospital, Switzerland.
MYRIAM SCHLUEP*
Affiliation:
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
*
*Correspondence and reprint requests to: Dr. Myriam Schluep, Department of Neurology BH07, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland. E-mail: [email protected].
Get access Rights & Permissions [Opens in a new window]

Abstract

The purpose of this study was to evaluate longitudinally, using the Iowa Gambling Task (IGT), the dynamics of decision-making capacity at a two-year interval (median: 2.1 years) in a group of patients with multiple sclerosis (MS) (n = 70) and minor neurological disability [Expanded Disability Status Scale (EDSS) ≤ 2.5 at baseline]. Cognition (memory, executive functions, attention), behavior, handicap, and perceived health status were also investigated. Standardized change scores [(score at retest-score at baseline)/standard deviation of baseline score] were computed. Results showed that IGT performances decreased from baseline to retest (from 0.3, SD = 0.4 to 0.1, SD = 0.3, p = .005). MS patients who worsened in the IGT were more likely to show a decreased perceived health status and emotional well-being (SEP-59; p = .05 for both). Relapsing rate, disability progression, cognitive, and behavioral changes were not associated with decreased IGT performances. In conclusion, decline in decision making can appear as an isolated deficit in MS. (JINS, 2009, 15, 291–295.)

Keywords

Iowa Gambling TaskLongitudinal studyDemyelinating diseasesCognitionBehaviorEmotion
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 2 , March 2009 , pp. 291 - 295
Copyright
Copyright © INS 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bechara, A. (2001). Neurobiology of decision making: Risk and reward. Seminars in Clinical Neuropsychiatry, 6, 205–216.CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, A.R., Damasio, H., & Anderson, S.W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50, 7–15.CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, H., & Damasio, A.R. (2000). Emotion, decision making and the orbitofrontal cortex. Cerebral Cortex, 10, 295–307.CrossRefGoogle ScholarPubMed
Damasio, A.R. (1994). Descartes’ error: Emotion, reason and the human brain. New York: Grosset Putnam.Google Scholar
Ernst, M. & Paulus, M.P. (2005). Neurobiology of decision making: A selective review from a neurocognitive and clinical perspective. Biological Psychiatry, 58, 597–604.CrossRefGoogle ScholarPubMed
Hernandez, M., An, H., & Bechara, A. (2006). Development of parallel versions of the Iowa Gambling Task for repeat testing. Journal of the International Neuropsychological Society, 12(Suppl. 1), 44.Google Scholar
Kleeberg, J., Bruggimann, L., Annoni, J.M., van Melle, G., Bogousslavsky, J., & Schluep, M. (2004). Altered decision-making capacity in multiple sclerosis: A sign of impaired emotional reactivity? Annals of Neurology, 56, 787–795.CrossRefGoogle ScholarPubMed
Kurtzke, J. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33, 1444–1452.CrossRefGoogle ScholarPubMed
McDonald, W.I., Compston, A., Edan, G., Goodkin, D., Hartung, H.P., Lublin, F.D., McFarland, H.F., Paty, D.W., Polman, C.H., Reingold, S.C., Sandberg-Wollheim, M., Sibley, W., Thompson, A., van den Noort, S., Weinshenker, B.Y., & Wolinsky, J.S. (2001). Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis. Annals of Neurology, 50, 121–127.CrossRefGoogle ScholarPubMed
Nagy, H., Bencsik, K., Rajda, C., Benedek, K., Beniczky, S., Kéri, S., & Vécsei, L. (2006). The effects of reward and punishment contingencies on decision making in multiple sclerosis. Journal of the International Neuropsychological Society, 12, 559–565.CrossRefGoogle ScholarPubMed
Pascual, A.M., Martínez-Bisbal, M.C., Boscá, I., Valero, C., Coret, F., Martínez-Granados, B., Marti-Bonmati, L., Mir, A., Celda, B., & Casanova, B. (2007). Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 69, 63–67.CrossRefGoogle ScholarPubMed
Polman, C.H., Reingold, S.C., Edan, G., Filippi, M., Hartung, H.P., Kappos, L., Lublin, F.D., Metz, L.M., McFarland, H.F., O’Connor, P.W., Sandberg-Wollheim, M., Thompson, A.J., Weinshenker, B.G., & Wolinsky, J.S. (2005). Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria.” Annals of Neurology, 58, 840–846.CrossRefGoogle Scholar
Roca, M., Torralva, T., Meli, F., Fiol, M., Calcagno, M.L., Carpintiero, S., De Pino, G., Ventrice, F., Martín, M.E., Vita, L., Manes, F., & Correale, J. (2008). Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts. Multiple Sclerosis, 14, 364–369.CrossRefGoogle ScholarPubMed
Simioni, S., Ruffieux, C., Bruggimann, L., Annoni, J.M., & Schluep, M. (2007). Cognition, mood and fatigue in patients in the early stage of multiple sclerosis. Swiss Medical Weekly, 137, 496–501.Google ScholarPubMed
Souza Lima, F., Simioni, S., Bruggimann, L., Ruffieux, C., Dudler, J., Felley, C., Michetti, P., Annoni, J.M., & Schluep, M. (2007). Perceived behavioural changes in early multiple sclerosis. Behavioural Neurology, 18, 81–90.CrossRefGoogle Scholar