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Predictors for Improvement of Problem-Solving during Cognitive Remediation for Patients with Schizophrenia

Published online by Cambridge University Press:  03 March 2014

Katlehn Rodewald ,
Daniel V. Holt ,
Mirjam Rentrop ,
Daniela Roesch-Ely ,
Michael Liebrenz ,
Joachim Funke ,
Matthias Weisbrod  and
Stefan Kaiser
Katlehn Rodewald
Affiliation:
Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
Daniel V. Holt
Affiliation:
Department of Psychology, University of Heidelberg, Heidelberg, Germany
Mirjam Rentrop
Affiliation:
Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
Daniela Roesch-Ely
Affiliation:
Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
Michael Liebrenz
Affiliation:
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland
Joachim Funke
Affiliation:
Department of Psychology, University of Heidelberg, Heidelberg, Germany
Matthias Weisbrod
Affiliation:
Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany Department of Psychiatry, SRH Hospital Karlsbad-Langensteinbach, Karlsbad, Germany
Stefan Kaiser*
Affiliation:
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
*
Correspondence and reprint requests to: Stefan Kaiser, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31,8032 Zurich, Switzerland. E-mail: [email protected]
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Abstract

Cognitive remediation is a promising pathway for ameliorating cognitive impairment of patients with schizophrenia. Here, we investigate predictors of improvement in problem-solving ability for two different types of cognitive remediation – specific problem-solving training and training of basic cognition. For this purpose we conducted a re-analysis of a randomized controlled trial comparing these two training approaches. The main outcome measure was improvement in problem-solving performance. Correlational analyses were used to assess the contribution of clinical, cognitive and training-related predictors. In the problem-solving training group, impaired pre-training planning ability was associated with stronger improvement. In contrast, in the basic cognition training group antipsychotic medication dose emerged as a negative predictor. These results demonstrate that predictors for successful cognitive remediation depend on the specific intervention. Furthermore, our results suggest that at least in the planning domain patients with impaired performance benefit particularly from a specific intervention. (JINS, 2014, 20, 1–6)

Keywords

Cognitive impairmentPlanningBasic cognitionRandomized controlled trialIndividualized cognitive remediationAntipsychotic dose
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 4 , April 2014 , pp. 455 - 460
Copyright
Copyright © The International Neuropsychological Society 2014 

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