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Personalized high-definition transcranial direct current stimulation improves cognition following carbon monoxide poisoning induced amnesia: A case report

Published online by Cambridge University Press:  03 December 2024

Brett S Schneider Open the ORCID record for Brett S Schneider [Opens in a new window] ,
Melvin McInnis ,
Victor Di Rita  and
Benjamin M Hampstead Open the ORCID record for Benjamin M Hampstead [Opens in a new window]
Brett S Schneider
Affiliation:
Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Melvin McInnis
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Victor Di Rita
Affiliation:
Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Benjamin M Hampstead*
Affiliation:
Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
*
Corresponding author: Benjamin M Hampstead; Email: [email protected]
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Abstract

Objective:

High-definition transcranial direct current stimulation (HD-tDCS) has the potential to improve cognitive functioning following neurological injury and in neurodegenerative conditions. In this case report, we present the first use of HD-tDCS in a person with severe anterograde amnesia following carbon monoxide poisoning.

Method:

The participant underwent two rounds of HD-tDCS that were separated by 3 months (Round 1 = 30 sessions; Round 2 = 31 sessions). We used finite element modeling of the participant’s structural MRI to develop an individualized montage that targeted multiple brain regions involved in memory encoding, as identified by Neurosynth.

Results:

Overall, the participant’s objective cognitive functioning improved significantly following Round 1, declined during the 2 months without HD-tDCS, and again improved following Round 2. Subjective informant reports from family and medical personnel followed this same pattern of improvement following each round with a decline in between rounds. We also provide preliminary evidence of altered brain activity during a learning/memory task using functional near-infrared spectroscopy, which may help establish the physiological effects of HD-tDCS in future work.

Conclusion:

Overall, these findings reinforce the potential value of HD-tDCS as a user-friendly method of enhancing cognition following anoxic/hypoxic brain injury.

Keywords

Transcranial direct current stimulationmemory trainingspectroscopyelectric stimulationnear-infraredbrain plasticity
Type
Case Report
Information
Journal of the International Neuropsychological Society , Volume 30 , Issue 10 , December 2024 , pp. 1015 - 1021
Creative Commons
This is a work of the US Government and is not subject to copyright protection within the United States. Published by Cambridge University Press on behalf of International Neuropsychological Society.
Copyright
© Department of Veterans Affairs, 2024

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