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Normal perceptual priming of orthographically illegal nonwords in amnesia

Published online by Cambridge University Press:  26 February 2009

Margaret M. Keane ,
John D.E. Gabrieli ,
Julia S. Noland  and
Susan Ingemanson McNealy
Margaret M. Keane
Affiliation:
Memory Disorders Research Center, Boston University School of Medicine and Department of Veterans Affairs Medical Center, Boston, MA 02130
John D.E. Gabrieli
Affiliation:
Memory Disorders Research Center, Boston University School of Medicine and Department of Veterans Affairs Medical Center, Boston, MA 02130 Department of Psychology, Stanford University, Stanford, CA 94305
Julia S. Noland
Affiliation:
Memory Disorders Research Center, Boston University School of Medicine and Department of Veterans Affairs Medical Center, Boston, MA 02130
Susan Ingemanson McNealy
Affiliation:
Department of Psychology, Stanford University, Stanford, CA 94305
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Abstract

This study examined priming in perceptual identification of orthographically illegal nonwords in control subjects and patients with global amnesia. Subjects studied a list of orthographically illegal nonwords and then performed a perceptual identification task in which half of the stimuli were from the prior study list and half were new (unstudied) stimuli. Priming was reflected in enhanced identification accuracy of studied compared to unstudied nonwords. Amnesic patients showed significant and normal priming despite impaired recognition memory performance. Because the experimental stimuli were dissimilar to real words in terms of orthography and phonology, it is unlikely that this priming effect was mediated by activation of pre-existing representations of orthographically or phonologically similar words, morphemes, or syllables. These results demonstrate that intact perceptual priming in amnesia is not limited to stimuli that are premorbidly represented in long-term knowledge, nor to novel stimuli that conform to the rules that characterize familiar items. Further, because the experimental stimuli comprised novel letter assemblies, the results suggest that amnesic patients can show normal priming for new perceptual associations. These findings demonstrate that processes spared in amnesia can support the creation and subsequent retrieval of novel stimulus representations. (JINS, 1995, I, 425–433.)

Keywords

AmnesiaPrimingNonwords
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 1 , Issue 5 , September 1995 , pp. 425 - 433
Copyright
Copyright © The International Neuropsychological Society 1995

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References

Blaxton, T.A. (1989). Investigating dissociations among mem ory measures: Support for a transfer-appropriate processing framework. Journal of Experimental Psychology: Learning, Memory, and Cognition, 15, 657–668.Google Scholar
Bowers, J.S. (1994). Does implicit memory extend to legal and illegal nonwords? Journal of Experimental Psychology: Learning, Memory, and Cognition, 20, 534–549.Google ScholarPubMed
Cermak, L.S., Bleich, R.P., & Blackford, S.P. (1988). Deficits in implicit retention of new associates by alcoholic Korsakoff patients. Brain and Cognition, 7, 312–323.CrossRefGoogle ScholarPubMed
Cermak, L.S., Talbot, N., Chandler, K., & Wolbarst, L.R. (1985). The perceptual priming phenomenon in amnesia. Neuropsychologia, 23, 615–622.CrossRefGoogle ScholarPubMed
Cohen, N.J. & Squire, L.R. (1980). Preserved learning and re tention of pattern-analyzing skill in amnesia: Dissociation of knowing how and knowing that. Science, 10, 207–210.CrossRefGoogle Scholar
Corkin, S. (1968). Acquisition of motor skill after bilateral me dial temporal-lobe excision. Neuropsychologia, 6, 255–265.CrossRefGoogle Scholar
Diamond, R. & Rozin, P. (1984). Activation of existing mem ories in the amnesic syndromes. Journal of Abnormal Psy chology, 93, 98–105.CrossRefGoogle Scholar
Dorfman, J. (1994). Sublexical components in implicit memory for novel words. Journal of Experimental Psychology: Learn ing, Memory, and Cognition, 20, 1108–1125.Google ScholarPubMed
Feustel, T.C., Shiffrin, R.M., & Salasoo, A. (1983). Episodic and lexical contributions to the repetition effect in word identification. Journal of Experimental Psychology: General, 112, 309–346.CrossRefGoogle Scholar
Gabrieli, J. D.E., Corkin, S., Mickel, S.F., & Growdon, J.H. (1993). Intact acquisition and long-term retention of mirror tracing skill in Alzheimer's disease and in global amnesia. Be havioral Neuroscience, 107, 899–910.CrossRefGoogle ScholarPubMed
Gabrieli, J.D.E., Fleischman, D.A., Keane, M.M., Reminger, S.L., & Morrell, F. (1995). Double dissociation between memory systems underlying explicit and implicit memory in the human brain. Psychological Science, 6, 76–82.CrossRefGoogle Scholar
Gabrieli, J.D.E., Keane, M.M., Stanger, B.Z., Kjelgaard, M.M., Growdon, J.H., & Corkin, S. (1994). Dissociations among perceptual-structural, lexical-semantic, and event-fact memory systems in amnesic, Alzheimer's, and normal subjects. Cortex, 30, 75–103.CrossRefGoogle ScholarPubMed
Gabrieli, J.D.E., Milberg, W., Keane, M.M., & Corkin, S.(1990). Intact priming of patterns despite impaired memory. Neuropsychologia, 28, 417–427.CrossRefGoogle ScholarPubMed
Gooding, P.A., van Eijk, R., Mayes, A.R., & Meudell, P. (1993). Preserved pattern completion priming for novel ab stract geometric shapes in amnesics of several aetiologies. Neuropsychologia, 31, 789–810.CrossRefGoogle Scholar
Gooding, P.A., Mayes, A.R., & Meudell, P. (1994). Long lasting indirect memory performance for abstract shapes in amnesics and matched controls. Neuropsychologia, 32, 1135–1143.CrossRefGoogle ScholarPubMed
Graf, P. & Mandler, G. (1984). Activation makes words more ac cessible, but not necessarily more retrievable. Journal of Ver bal Learning and Verbal Behavior, 23, 553–568.CrossRefGoogle Scholar
Graf, P. & Schacter, D.L. (1985). Implicit and explicit memory for new associations in normal and amnesic subjects. Journal of Experimental Psychology: Learning, Memory, and Cognition, 11, 501–518.Google ScholarPubMed
Graf, P., Squire, L.R., & Mandler, G. (1984). The information that amnesic patients do not forget. Journal of Experimen tal Psychology: Learning, Memory, and Cognition, 10, 164–178.Google Scholar
Haist, F., Musen, G., & Squire, L.R. (1991). Intact priming of words and nonwords in amnesia. Psychobiology, 19, 275–285.CrossRefGoogle Scholar
Jernigan, T.L. & Ostergaard, A.L. (1993). Word priming and recognition memory are both affected by mesial temporal lobe damage. Neuropsychology, 7, 14–26.CrossRefGoogle Scholar
Keane, M.M., Gabrieli, J.D.E., Fennema, A.C., Growdon, J.H., & Corkin, S. (1991). Evidence for a dissociation be tween perceptual and conceptual priming in Alzheimer's disease. Behavioral Neuroscience, 105, 326–342.CrossRefGoogle Scholar
Keane, M.M., Gabrieli, J.D.E., Growdon, J.H., & Corkin, S. (1994). Priming in perceptual identification of pseudowords is normal in Alzheimer's disease. Neuropsychologia, 32, 343–356.CrossRefGoogle ScholarPubMed
Keane, M.M., Gabrieli, J.D.E., Mapstone, H.C., Johnson, K.A., & Corkin, S. (in press). Double dissociation of memory capacities after bilateral occipital-lobe or medial temporal lobe lesions. Brain.Google Scholar
Mayes, A.R. & Gooding, P. (1989). Enhancement of word com pletion priming in amnesics by cueing with previously novel associates. Neuropsychologia, 27, 1057–1072.CrossRefGoogle Scholar
Milner, B. (1962). Les troubles de la mémoire accompagnant des lésions hippocampiques bilatérales. In Passouant, P. (Ed.), Physiologie de l’Hippocampe (pp. 247–272). Paris: Centre National de la Recherche Scientifique.Google Scholar
Moscovitch, M., Winocur, G., & McLachlan, D. (1986). Memory as assessed by recognition and reading time in normal and memory-impaired people with Alzheimer's disease and other neurological disorders. Journal of Experimental Psychology: General, 115, 331–347.CrossRefGoogle ScholarPubMed
Musen, G. & Squire, L.R. (1992). Nonverbal priming in amne sia. Memory and Cognition, 20, 441–448.CrossRefGoogle Scholar
Musen, G. & Squire, L.R. (1993). On the implicit learning of novel associations by amnesic patients and normal subjects. Neuropsychology, 7, 119–135.CrossRefGoogle Scholar
Paller, K.A. & Mayes, A.R. (1994). New-association priming of word identification in normal and amnesic subjects. Cortex, 30, 53–73.CrossRefGoogle ScholarPubMed
Paller, K.A., Mayes, A.R., Thompson, K.M., Young, A.W., Roberts, J., & Meudell, P.R. (1992). Priming of face matching in amnesia. Brain and Cognition, 18, 46–59.CrossRefGoogle ScholarPubMed
Posner, M.I. & Raichle, M.E. (1994). Images of mind. New York: Scientific American Library.Google Scholar
Rueckl, J.G. (1990). Similarity effects in word and pseudoword repetition priming. Journal of Experimental Psychology: Learning, Memory, and Cognition, 16, 374–391.Google ScholarPubMed
Rugg, M.D. & Nagy, M.E. (1987). Lexical contribution to nonword-repetition effects: Evidence from event-related potentials. Memory and Cognition, 15, 473–481.CrossRefGoogle ScholarPubMed
Salasoo, A., Shiffrin, R.M., & Feustel, T.C. (1985). Building permanent memory codes: Codification and repetition effects in word identification. Journal of Experimental Psychology: General, 114, 50–77.CrossRefGoogle ScholarPubMed
Schacter, D.L., Cooper, L.A., & Delaney, S.M. (1990a). Implicit memory for unfamiliar objects depends on access to structural descriptions. Journal of Experimental Psychology: General, 119, 5–24.CrossRefGoogle ScholarPubMed
Schacter, D.L., Cooper, L.A., Delaney, S.M., Peterson, M.A., & Tharan, M. (1991a). Implicit memory for possible and im possible objects: Constraints on the construction of structural descriptions. Journal of Experimental Psychology: Learning, Memory, and Cognition, 17, 3–19.Google Scholar
Schacter, D.L., Cooper, L.A., Tharan, M., & Rubens, A.B. (1991b). Preserved priming of novel objects in patients with memory disorders. Journal of Cognitive Neuroscience, 3, 117–130.CrossRefGoogle ScholarPubMed
Schacter, D.L. & Graf, P. (1986a). Effects of elaborative pro cessing on implicit and explicit memory for new associations. Journal of Experimental Psychology: Learning, Memory, and Cognition, 12, 432–444.Google Scholar
Schacter, D.L. & Graf, P. (1986b). Preserved learning in amnesic patients: Perspectives from research on direct priming. Journal of Clinical and Experimental Neuropsychology, 8, 727–743.CrossRefGoogle ScholarPubMed
Schacter, D.L., Rapscak, S.Z., Rubens, A.B., Tharan, M., & Laguna, J. (1990b). Priming effects in a letter-by-letter reader depend upon access to the word form system. Neuropsychologia, 28, 1079–1094.CrossRefGoogle Scholar
Shimamura, A.P. & Squire, L.R. (1989). Impaired priming of new associations in amnesia. Journal of Experimental Psychology: Learning, Memory, and Cognition, 15, 721–728.Google ScholarPubMed
Squire, L.R. (1987). Memory and brain. New York: Oxford University Press.Google Scholar
Verfaellie, M., Milberg, W.P., Cermak, L.S., & Letourneau, L.L. (1992). Priming of spatial configurations in alcoholic Korsakoff's amnesia. Brain and Cognition, 18, 34–45.CrossRefGoogle ScholarPubMed
Warrington, E.K. & Weiskrantz, L. (1968). New method of testing long-term retention with special reference to amnesic patients. Nature, 217, 972–974.CrossRefGoogle ScholarPubMed
Warrington, E.K. & Weiskrantz, L. (1970). Amnesic syndrome: Consolidation or retrieval? Nature, 228, 628–630.CrossRefGoogle ScholarPubMed
Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised [manual]. New York: Psychological Corp.Google Scholar
Wechsler, D. (1987). Wechsler Memory Scale-Revised [manual]. New York: Psychological Corp.Google Scholar
Weldon, M.S. (1991). Mechanisms underlying priming on perceptual tests. Journal of Experimental Psychology: Learning, Memory, and Cognition, 17, 526–541.Google ScholarPubMed