Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-28T14:29:33.071Z Has data issue: false hasContentIssue false

Neuropsychological Deficits In HIV-1 seropositive and seronegative intravenous drug users (IVDUs): A follow-up study

Published online by Cambridge University Press:  26 February 2009

Knut Hestad
Affiliation:
Section of Clinical Neuropsychology, Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway
Pȧl Aukrust
Affiliation:
Section of Clinical Immunology and Infectious Diseases, Medical Department A, The National Hospital, University of Oslo, Oslo, Norway
Bjørn Ellertsen
Affiliation:
Section of Clinical Neuropsychology, Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway
Hallgrim Kløve
Affiliation:
Section of Clinical Neuropsychology, Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway

Abstract

Human immunodeficiency virus type 1 (HIV-1) seropositive AIDS free and HIV-1 seronegative intravenous drug users were tested twice with a comprehensive neuropsychological test battery. Only minor group differences were found. Memory difficulties were the most pronounced difference with lower scores in the HIV-1 seropositive group. The memory difficulties were to some degree associated with emotional difficulties, that is, anxiety. The HIV-1 seropositive subjects were tested a third time and there was no further decline in any test with memory content at this testing. The only test that showed a significant decline in the HIV-1 seropositive group was the Trail Making Test. (JINS, 1996, 2, 126–133.)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bornstein, R.A. (1983). Construct validity of the Knox Cube Test as a neuropsychological measure. Journal of Clinical Neuropsychology, 5, 105114.CrossRefGoogle ScholarPubMed
Bornstein, R.A., Nasrallah, H.A., Para, M.F., Whitacre, C.C., Rosenberger, P., Fass, R.J., & Rice, R. Jr. (1992). Neuropsychological performance in asymptomatic HIV infection. Journal of Neuropsychiatry, 4(4), 386394.Google ScholarPubMed
Centers for Disease Control and Prevention. (1992). 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR, 41, 119.Google Scholar
Derogatis, L.R., Lipman, R.S., Covi, L. (1973). SCL-90: An outpatient psychiatric rating scale-preliminary report. Psychopharmacological Bulletin, 3, 1328.Google Scholar
Dilley, J.W., Boccellari, A., & Heilbron, D. (1988). Central nervous involvement in the acquired immunodeficiency syndrome (AIDS) (letter). Annals of Internal Medicine, 8, 508509.CrossRefGoogle Scholar
Egan, V., Brettle, R.P., & Goodwin, C.M. (1992). The Edinburgh cohort of HIV-positive drug users: Pattern of cognitive impairment in relation to progression of disease. British Journal of Psychiatry, 161, 522531.CrossRefGoogle ScholarPubMed
Grant, I., Atkinson, J.H., Hesselink, J.R., Kennedy, C.J., Richman, D.D., Spector, S.A., & McCutchan, J.A. (1987). Evidence for early central nervous system involvement in the acquired immunodeficiency virus (HIV) infections. Annals of Internal Medicine, 107, 823836.CrossRefGoogle ScholarPubMed
Grant, I., Atkinson, J.H., Hesselink, J.R., Kennedy, C.J., Richman, D.D., Spector, S.A., & McCutchan, J.A. (1988). Letters and corrections. Annals of Internal Medicine, 8, 509510.Google Scholar
Heaton, R.K., Grant, I., Butters, N., White, D.A., Kirson, D., Atkinson, J.H., McCutchan, J.A., Taylor, M.J., Kelly, M.D., Ellis, R.J., Wolfson, T., Velin, R., Marcotte, T.D., Hesselink, J.R., Jernigan, T.L., Chandler, J., Wallace, M., Abrason, I., & the HNRC Group. (1995). The HNRC 500-Neuropsychology of HIV infection at different disease stages. Journal of the International Neuropsychological Society, 1, 231251.CrossRefGoogle ScholarPubMed
Hestad, K., Aukrust, P., Ellertsen, B., & Klove, H. (1994). Psychological difficulties related to human immunodeficiency virus-1 infection in intravenous drug users. Acta Psychiatrica Scandinavica, 90, 2531.CrossRefGoogle ScholarPubMed
Hestad, K., Aukrust, P., Ellertsen, B., Kløve, H., & Wilberg, K. (1993). Neuropsychological deficits in HIV-1 seropositive and seronegative intravenous drug users. Journal of Clinical and Experimental Neuropsychology, 15, 732742.CrossRefGoogle ScholarPubMed
Hestad, K., Updike, M., Selnes, O.A., & Royal III, W. (1995). Cognitive sequelae of repeated head injury in a population of intravenous drug users. Scandinavian Journal of Psychology, 36, 246255.CrossRefGoogle Scholar
Martin, E.M., Robertson, L.C., Edelstein, H.E., Jagust, W.J., Sorensen, D.J., San Giovanni, D., & Chirurgi, V.A. (1992). Performance of patients with early HIV-1 infection on the Stroop Task. Journal of Clinical and Experimental Neuropsychology, 14(5), 857868.CrossRefGoogle ScholarPubMed
Miller, E.N., Selnes, O.A., Visscher, B., McArthur, J., Satz, P., & Dudley, J. (1989). Changes in performance on the Trail-Making test before and after HIV-1 seroconversion and diagnosis of A IDS: The multicenterA IDS cohort study (MACS). Vth International Conference on AIDS, Montreal, June 49, 1989; Abstract No. Th. B. P. 288.Google Scholar
Miller, E.N., Selnes, O.A., McArthur, J.C., Satz, P., Becker, J.T., Cohen, B.A., Sheridan, K., Machado, A.M., Van Gorp, W.G., & Visscher, B. (1990). Neuropsychological performance in HIV-1-infected homosexual men: The multicenter AIDS cohort study (MACS). Neurology, 40, 197203.CrossRefGoogle ScholarPubMed
Poutiainen, E., Elovaara, I., Hokkanen, L., Valle, S.-L., Lahdevirta, J., & Iivanainen, M. (1993). Cognitive performance in HIV-1 infection: Relationship to severity of disease and brain atrophy. Acta Neurologica Scandinavica, 87(2), 8894.CrossRefGoogle ScholarPubMed
Reitan, R.M. & Davison, L.A. (1974). Clinical neuropsychology: Current status and applications. New York: Hemisphere.Google Scholar
Rubinow, W.R., Berrettini, C.H., Bouwers, P., & Lane, H.C. (1988). Neuropsychiatric consequences of AIDS. Annals of Neurology, 23(suppl.), 2426.CrossRefGoogle Scholar
Saykin, A.J., Janssen, R.S., Sprehn, G.C., Kaplan, J.E., Spira, T.J., & O'Connor, B. (1991). Longitudinal evaluation of neuropsychological function in homosexual men with HIV infection: 18-month follow-up. Journal of Neuropsychiatry and Clinical Neuroscience, 3(3), 286298.Google ScholarPubMed
Selnes, O.A., Galai, N., Bacellar, H., Miller, E.N., Becker, J.T., Wesch, J., Van Gorp, W., & McArthur, J.C. (1995). Cognitive performance after progression to AIDS: A longitudinal study from the Multicenter AIDS Cohort Study. Neurology, 45, 267275.CrossRefGoogle ScholarPubMed
Selnes, O.A., McArthur, J.C., Gordon, B., Miller, E.N., McArthur, J.H., & Saah, A. (1991). Patterns of cognitive decline in incident HIV-dementia: Longitudinal observations from the Multicenter AIDS Cohort Study. AAN Scientific Meeting, Boston, MA, April 27, 1991.Google Scholar
Selnes, O.A., McArthur, J.C., Royal, W. III, Udike, M.L., Nance-Sproson, T., Concha, M., Gordon, B., Solomon, L., & Vlahov, D. (1992). HIV-1 infection and intravenous drug use: Longitudinal neuropsychological evaluation of asymptomatic subjects. Neurology, 42, 19241930.CrossRefGoogle ScholarPubMed
Selnes, O.A., Miller, E., McArthur, J., Gordon, B., Muños, A., Sheridan, K., Fox, R., & Saah, A.J. (1990). HIV-1 infection: No evidence of cognitive decline during the asymptomatic stages. Neurology, 40, 204208.CrossRefGoogle ScholarPubMed
Wechsler, D. (1945). A standardized memory scale for clinical use. Journal of Clinical Neuropsychology, 19, 8795.Google Scholar
Wechsler, D. (1955). Wechsler Adult Intelligence Scale. New York: The Psychological Corporation.Google Scholar
White, D.A., Heaton, R.K., Monsch, A.U., & the HNRC Group. (1995). Critical review. Neuropsychological studies of asymptomatic human immunodeficiency virus-type-1 infected individuals. Journal of the International Neuropsychological Society, 1, 305315.CrossRefGoogle Scholar