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Neurocognitive profiles in elderly patients with frontotemporal degeneration or major depressive disorder

Published online by Cambridge University Press:  01 September 2004

VIRGINIA ELDERKIN-THOMPSON ,
KYLE B. BOONE ,
SUN HWANG  and
ANAND KUMAR
VIRGINIA ELDERKIN-THOMPSON
Affiliation:
Neuropsychiatric Research Institute & Hospital, Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, California
KYLE B. BOONE
Affiliation:
Harbor-UCLA Medical Center, Department of Psychiatry, University of California, Los Angeles, California
SUN HWANG
Affiliation:
Neuropsychiatric Research Institute Biostat Core, Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, California
ANAND KUMAR
Affiliation:
Neuropsychiatric Research Institute & Hospital, Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, California
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Abstract

Major depressive disorder (MDD) and frontotemporal dementia (FTD) are both disorders in elderly populations that involve the prefrontal cortex and appear to have similar neurocognitive deficits. This review examined whether there are testable deficits in cognition that are consistent across individuals within the same neuropathological condition that could be used to facilitate early diagnoses. Medline and PsychInfo databases were searched for cognitive studies of depressed and FTD patients that used a matched control group and reported findings with means and standard deviations (N = 312). Effect sizes for FTD patients with mild and moderately advanced disease were compared to effect sizes within subgroups of depressed patients, such as inpatients, outpatients and community volunteers. Moderately advanced FTD patients were more impaired than depressed patients over all domains, particularly in language ability, although depressed inpatients appeared similar to FTD patients in some domains. Effect sizes for FTD patients who were in the mild, or early, stage of the disease (MMSE = 28) were similar to those of depressed outpatients but slightly worse than those of community volunteers in all domains except semantic memory and executive ability. In the latter two domains, even mild FTD patients had notably large deficits. All FTD patients showed more severe deficits in some domains relative to other domains. In contrast, depressed patients tended to vary by clinical presentation or disease severity, but the magnitude of impairment for each subgroup remained relatively consistent across domains and they did not have the severe focal deficits in one or two domains demonstrated by FTD patients. (JINS, 2004, 10, 753–771.)

Keywords

Frontotemporal dementiaDepressionCognitionElderlyNeuropsychology
Type
CRITICAL REVIEW
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 5 , September 2004 , pp. 753 - 771
Copyright
2004 The International Neuropsychological Society

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References

REFERENCES

Abas, M.A., Sahakian, B.J., & Levy, R. (1990). Neuropsychological deficits and CT scan changes in elderly depressives. Psychological Medicine, 20, 507–520.CrossRefGoogle Scholar
Alexopoulos, G.S. (2002). Frontostriatal and limbic dysfunction in late-life depression. American Journal of Geriatric Psychiatry, 10, 687–695.CrossRefGoogle Scholar
Alexopoulos, G.S., Meyers, B.S., Young, R.C., Kalayam, B., Kakuma, T., Gabrielle, M., Sirey, J.A., & Hull, J. (2000). Executive dysfunction and long-term outcomes of geriatric depression. Archives of General Psychiatry, 57, 285–290.CrossRefGoogle Scholar
Awata, S., Ito, H., Konno, M., Ono, S., Kawashima, R., Fukuda, H., & Sato, M. (1998). Regional cerebral blood flow abnormalities in late-life depression: relation to refractoriness and chronification. Psychiatry and Clinical Neuroscience, 52, 97–105.CrossRefGoogle Scholar
Baddeley, A., Della, S.S., Papagno, C., & Spinnler, H. (1997). Dual-task performance in dysexecutive and nondysexecutive patients with a frontal lesion. Neuropsychology, 11, 187–194.CrossRefGoogle Scholar
Bartolic, E.I., Basso, M.R., Schefft, B.K., Glauser, T., & Titanic-Schefft, M. (1999). Effects of experimentally-induced emotional states on frontal lobe cognitive task performance. Neuropsychology, 37, 677–683.CrossRefGoogle Scholar
Baxter, L.R., Jr., Schwartz, J.M., Phelps, M.E., Mazziotta, J.C., Guze, B.H., Selin, C.E., Gerner, R.H., & Sumida, R.M. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry, 46, 243–250.CrossRefGoogle Scholar
Beats, B.C., Sahakian, B.J., & Levy, R. (1996). Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychological Medicine, 26, 591–603.CrossRefGoogle Scholar
Bench, C.J., Frackowiak, R.S., & Dolan, R.J. (1995). Changes in regional cerebral blood flow on recovery from depression. Psychological Medicine, 25, 247–261.CrossRefGoogle Scholar
Bench, C.J., Friston, K.J., Brown, R.G., Scott, L.C., Frackowiak, R.S., & Dolan, R.J. (1992). The anatomy of melancholia—focal abnormalities of cerebral blood flow in major depression. Psychological Medicine, 22, 607–615.CrossRefGoogle Scholar
Benton, A.L., Hamsher, K. de S., Varney, N.R., & Spreen, O. (1989). Judgment of line orientation. New York: Oxford University Press.
Benton, A.L. & Hamsher, K. de S. (1989). Multilingual Aphasia Examination. Iowa City, IA: AJA Associates.
Berg, E.A. (1948). A simple objective treatment for measuring flexibility in thinking. Journal of General Psychology, 39, 15–22.CrossRefGoogle Scholar
Bishop, D.V.M. (1983). Test for the reception of grammar. Manchester, UK: University of Manchester.
Biver, F., Goldman, S., Delvenne, V., Luxen, A., De Maertelaer, V., Hubain, P., Mendlewicz, J., & Lotstra, F. (1994). Frontal and parietal metabolic disturbances in unipolar depression. Biological Psychiatry, 36, 381–388.CrossRefGoogle Scholar
Bondi, M.W., Salmon, D.P., Galasko, D., Thomas, R.G., & Thal, L.J. (1999). Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology and Aging, 14, 295–303.CrossRefGoogle Scholar
Bondi, M.W., Salmon, D.P., Monsch, A.U., Galasko, D., Butters, N., Klauber, M.R., & Thal, L.J. (1995). Episodic memory changes are associated with the APOE-episolon 4 allele in nondemented older adults. Neurology, 45, 2203–2206.CrossRefGoogle Scholar
Boone, E.B., Lesser, I.B., Miller, B.L., Wohl, M., Berman, N., Lee, A., Palmer, B., & Back, C. (1995). Cognitive functioning in older depressed outpatients: Relationship of presence and severity of depression to neuropsychological test scores. Neuropsychology, 9, 390–398.CrossRefGoogle Scholar
Boone, K.B., Lesser, I., Miller, B., Wohl, M., Berman, H., Lee, A., & Palmer, B. (1994). Cognitive functioning in a mildly to moderately depressed geriatric sample: Relationship to chronological age. Journal of Neuropsychiatry and Clinical Neurosciences, 6, 267–272.Google Scholar
Boone, K.B., Lesser, I.M., Hill-Gutierrez, E., & Evans, K.R. (1993). Rey-Osterrieth Complex Figure performance in healthy, older adults: Relationship to age, education, sex, and IQ. Clinical Neuropsychologist, 7, 22–28.CrossRefGoogle Scholar
Brody, A.L., Saxena, S., Silverman, D.H., Alborzian, S., Fairbanks, L.A., Phelps, M.E., Huang, S.C., Wu, H.M., Maidment, K., & Baxter_Jr., L.R. (1999). Brain metabolic changes in major depressive disorder from pre-to post-treatment with paroxetine. Psychiatry Research, 91, 127–139.CrossRefGoogle Scholar
Brun, A. (1999). The emergence of the frontal lobe and its morbidity, as opposed to the central lobe. Dementia & Geriatric Cognitive Disorders, 10 (Suppl. 1), 3–5.CrossRefGoogle Scholar
Brun, A., Englund, B., & Gustafson, L.E.A. (1994). Clinical and neuropathological criteria for frontotemporal dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 57, 886–896.Google Scholar
Buchsbaum, M.S., Wu, J., Siegel, B.V., Hackett, E., Trenary, M., Abel, L., & Reynolds, C. (1997). Effect of sertraline on regional metabolic rate in patients with affective disorder. Biological Psychiatry, 41, 15–22.CrossRefGoogle Scholar
Butters, M.A., Becker, J.T., Nebes, R.D., Zmuda, M.D., Mulsant, B.H., Pollock, B.G., & Reynolds, C.F., III. (2000). Changes in cognitive functioning following treatment of late-life depression. American of Journal Psychiatry, 157, 1949–1954.CrossRefGoogle Scholar
Byrum, C.E., Ahearn, E.P., & Krishnan, K.R. (1999). A neuroanatomic model for depression. Progress in Neuropsychopharmacology and Biological Psychiatry, 23, 175–193.CrossRefGoogle Scholar
Cappa, S.F., Binetti, G., Pezzini, A., Padovsni, S., Rozzini, L., & Trabucchi, M. (1998). Object and action naming in Alzheimer's disease and frontotemporal dementia. Neurology, 50, 351–355.CrossRefGoogle Scholar
Carlin, D., Bonerba, J., Phipps, M., Alexander, G., Shapiro, M., & Grafman, J. (2000). Planning impairments in frontal lobe dementia and frontal lesion patients. Neuropsychologia, 38, 655–665.CrossRefGoogle Scholar
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Assoc.
Curran, S.M., Murray, C.M., VanBeck, M., Dougall, N., O'Carrol, R.E., Austin, M.P., Ebmeier, K.P., & Goodwin, G.M. (1993). A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia. British Journal of Psychiatry, 163, 155–165.CrossRefGoogle Scholar
D'Esposito, M.D. & Postle, B.R. (1999). The dependence of span and delayed-response performance on prefrontal cortex. Neuropsychologia, 37, 1303–1315.CrossRefGoogle Scholar
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B.A. (1987). California Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation.
Della, S.S., Baddeley, A., Papagno, C., & Spinnler, H. (1995). Dual-task paradigm: A means to examine the central executive. Annals of New York Academy of Science, 769, 161–171.Google Scholar
Drevets, W.C., Videen, T.O., Price, J.L., Preskorn, S.H., Carmichael, S.T., & Raichle, M.E. (1992). A functional anatomical study of unipolar depression. Journal of Neuroscience, 12, 3628–3641.CrossRefGoogle Scholar
Drevets, W.C. (1999). Prefrontal cortical-amygdalar metabolism in major depression. Annals of New York Academy of Science, 877, 614–637.CrossRefGoogle Scholar
Drevets, W.C. (2000). Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Progress in Brain Research, 126, 413–431.CrossRefGoogle Scholar
Duke, L.M. & Kaszniak, A.W. (2000). Executive control functions in degenerative dementias: A comparative review. Neuropsychology Review, 10, 75–97.CrossRefGoogle Scholar
Dunkin, J.J., Leuchter, A.F., Cook, I.A., Kasl-Godley, J.E., Abrams, M., & Rosenberg-Thompson, S. (2001). Executive dysfunction predicts nonresponse to fluoxetine in major depression. Journal of Affective Disorders, 60, 13–23.Google Scholar
Dureman, I., & Sälde H. (1959). Psykometriska och experimental-psykologiska metodoer för klinish tillämpning. Uppsala, Sweden: Almqvist & Wiksell.
Elfgren, C., Passant, U., & Risberg, J. (1993). Neuropsychological findings in frontal lobe dementia. Dementia, 4, 214–219.CrossRefGoogle Scholar
Endicott, J. & Spitzer, R.L. (1978). A diagnostic interview: The schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837–844.CrossRefGoogle Scholar
Ernst, C. & Angst, J. (1995). Depression in old age. Is there a real decrease in prevalence? A review. European Archives of Psychiatry and Clinical Neuroscience, 245, 272–287.CrossRefGoogle Scholar
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini Mental State”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle Scholar
Frisoni, G.B., Pizzolato, G., Geroldi, C., Rossato, A., Bianchetti, A., & Trabucchi, M. (1995). Dementia of the frontal type: Neuropsychological and [99Tc]-HM-PAO SPECT features. Journal of Geriatric Psychiatry and Neurology, 8, 42–48.Google Scholar
Galton, C.J., Patterson, K., Graham, K., Lambon-Ralph, M.A., Williams, G., Antoun, N., Sahakian, B.J., & Hodges, J.R. (2001). Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology, 57, 216–225.CrossRefGoogle Scholar
Gatz, M., Johansson, B., Pedersen, N., Berg, S., & Reynolds, C. (1993). A cross-national self-report measure of depressive symptomatology. International Psychogeriatrics, 5, 147–156.CrossRefGoogle Scholar
Grant, D.A. & Berg, E.A. (1948). A behavioral analysis of the degree of reinforcement and ease of shifting to new responses in a Weigl-type card sorting problem. Journal of Experimental Psychology, 38, 310–324.Google Scholar
Gregory, C.A. & Hodges, J.R. (1993). Dementia of frontal type and the focal lobar arophies. International Review of Psychiatry, 5, 397–406.CrossRefGoogle Scholar
Gregory, C.A. & Hodges, J.R. (1996). Frontotemporal dementia: Use of consensus criteria and prevalence of psychiatric features. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 9, 145–153.Google Scholar
Gregory, C.A., Serra-Mestres, J., & Hodges, J.R. (1999). Early diagnosis of the frontal variant of frontotemporal dementia: How sensitive are standard neuroimaging and neuropsychologic tests? Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 12, 128–135.Google Scholar
Gustafson, L. (1987). Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Archives of Gerontology and Geriatrics, 6, 209–223.CrossRefGoogle Scholar
Gustafson, L., Brun, A., & Passant, U. (1992). Frontal lobe degeneration of non-Alzheimer type. Baillieres Clinical Neurology, 1, 559–582.Google Scholar
Hamsher, K. de S., Benton, A.L., & Digre, K. (1980). Serial digit learning: Normative and clinical aspects. Journal of Clinical Neuropsychology, 2, 39–50.CrossRefGoogle Scholar
Hebert, R., Lindsay, J., Verreault, R., Rockwood, K., Hill, G., & Dubois, M.-F. (2000). Vascular dementia. Incidence and risk factors in the Canadian Study of Health and Aging. Stroke, 31, 1487–1493.Google Scholar
Hodges, J.R. & Miller, B. (2001). The neuropsychology of frontal variant frontotemporal dementia and semantic dementia. Introduction to the special topic papers: Part II. Neurocase, 7, 113–121.Google Scholar
Hodges, J.R., Patterson, K., Oxbury, S., & Funnell, E. (1992). Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain, 115, 1783–1806.CrossRefGoogle Scholar
Hodges, J.R., Patterson, K., Ward, R., Garrard, P., Bak, T., Perry, R., & Gregory, C. (1999). The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: A comparative neuropsychological study. Neuropsychology, 13, 31–40.CrossRefGoogle Scholar
Husain, M.M., McDonald, W.M., Doraiswamy, P.M., Figiel, G.S., Na, C., Escalona, P.R., Boyko, O.B., Nemeroff, C.B., & Krishnan, K.R. (1991). A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Research, 40, 95–99.CrossRefGoogle Scholar
Jenkins, M., Malloy, P., Salloway, S., Cohen, R., Rogg, J., Tung, G., Kohn, R., Westlake, R., Johnson, E.G., & Richardson, E. (1998). Memory processes in depressed geriatric patients with and without subcortical hyperintensities on MRI. Journal of Neuroimaging, 8, 20–26.CrossRefGoogle Scholar
Johansson, B. & Zarit, S.H. (1991). Dementia and cognitive impairment in the oldest old: A comparison of two rating methods. International Psychogeriatrics, 3, 29–38.CrossRefGoogle Scholar
Jorm, A.F. (2001). History of depression as a risk factor for dementia: An updated review. Australian and New Zealand Journal of Psychiatry, 35, 776–781.CrossRefGoogle Scholar
Kaplan, E.F., Goodglass, H., & Weintraub, S. (1983). The Boston Naming Test (2nd ed.). Philadelphia: Lea & Febiger.
Kaszniak, A.W. & Christenson, G.D. (1994). Differential diagnosis of dementia and depression. In M. Storandt & G.R. VandenBos (Eds.), Neuropsychological assessment of dementia and depression in older adults: A clinician's guide (pp. 81–117). Washington, DC: American Psychological Association.
Kennedy, S.H., Evans, K.R., Kruger, S., Mayberg, H.S., Meyer, J.H., McCann, S., Arifuzzman, A.I., Houle, S., & Vaccarino, F.J. (2001). Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. American Journal of Psychiatry, 158, 899–905.CrossRefGoogle Scholar
King, D.A., Caine, E.D., Conwell, Y., & Cox, C. (1991). The neuropsychology of depression in the elderly: A comparative study of normal aging and Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neuroscience, 3, 163–168.Google Scholar
Kramer-Ginsberg, E., Greenwald, B.S., Krishnan, K.R., Christiansen, B., Hu, J., Ashtari, M., Patel, M., & Pollack, S. (1999). Neuropsychological functioning and MRI signal hyperintensities in geriatric depression. American Journal of Psychiatry, 156, 438–444.Google Scholar
Krishnan, K.R., McDonald, W.M., Escalona, P.R., Doraiswamy, P.M., Na, C., Husain, M.M., Figiel, G.S., Boyko, O.B., Ellinwood, E.H., & Nemeroff, C.B. (1992). Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Archives of General Psychiatry, 49, 553–557.CrossRefGoogle Scholar
Kumar, A., Bilker, W., Lavretsky, H., & Gottlieb, G. (2000). Volumetric asymmetries in late-onset mood disorders: An attenuation of frontal asymmetry with depression severity. Psychiatry Research, 100, 41–47.CrossRefGoogle Scholar
Kumar, A., Jin, A., Bilker, W., Udupa, J., & Gottlieb, G. (1998). Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI. Proceedings of the National Academy of Science, USA, 95, 7654–7658.CrossRefGoogle Scholar
Kumar, A., Mintz, J., Bilker, W., & Gottlieb, G. (2002). Autonomous neurobiological pathways to late-life major depressive disorder: Clinical and pathophysiological implications. Neuropsychopharmacology, 26, 229–236.CrossRefGoogle Scholar
Lai, T., Payne, M.E., Byrum, C.E., Steffens, D.C., & Krishnan, K.R. (2000). Reduction of orbital frontal cortex volume in geriatric depression. Biological Psychiatry, 48, 971–975.CrossRefGoogle Scholar
Lesser, I.M., Boone, K.B., Mehringer, C.M., Wohl, M.A., Miller, B.L., & Berman, N.G. (1996). Cognition and white matter hyperintensities in older depressed patients. American Journal of Psychiatry, 153, 1280–1287.Google Scholar
Lindsay, J., Laurin, D., Verreault, R., Herbert, R., Helliwell, B., Hill, G.B., & McDowell, I. (2002). Risk factors for Alzheimer's disease: A prospective analysis from the Canadian Study of Health and Aging. American Journal of Epidemiology, 156, 445–453.CrossRefGoogle Scholar
Lund and Manchester Groups. (1994). Clinical and neuropathological criteria for frontotemporal dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 57, 416–418.Google Scholar
Lyness, S.A., Eaton, E.M., & Schneider, L.S. (1994). Cognitive performance in older and middle-aged depressed outpatients and controls. Journal of Gerontology, 49, 129–136.CrossRefGoogle Scholar
MacFall, J.R., Payne, M.E., Provenzale, J.E., & Krishnan, K.R. (2001). Medial orbital frontal lesions in late-onset depression. Biological Psychiatry, 49, 803–806.CrossRefGoogle Scholar
Mayberg, H.S. (1997). Limbic-cortical dysregulation: A proposed model of depression. Journal of Neuropsychiatry and Clinical Neurosciences, 9, 471–481.Google Scholar
Mayberg, H.S., Lewis, P.J., Regenold, W., & Wagner, H.N., Jr. (1994). Paralimbic hypoperfusion in unipolar depression. Journal of Nuclear Medicine, 35, 929–934.Google Scholar
Mayberg, H.S., Liotti, M., Brannan, S.K., McGinnis, S., Mahurin, R.K., Jerabek, P.A., Silva, J.A., Tekell, J.L., Martin, C.C., Lancaster, J.L., & Fox, P.T. (1999). Reciprocal limbic–cortical function and negative mood: Coverging PET findings in depression and normal sadness. American Journal of Psychiatry, 156, 675–682.Google Scholar
Mehta, K.M., Yaffe, K., & Covinsky, K.E. (2002). Cognitive impairment, depressive symptoms, and functional decline in older people. Journal of the American Geriatric Society, 50, 1045–1050.CrossRefGoogle Scholar
Miller, B.L., Cummings, J.L., Villanueva-Meyer, J., Boone, K., Mehringer, C.M., Lesser, I.M., & Mena, I. (1991). Frontal lobe degeneration: Clinical, neuropsychological, and SPECT characteristics. Neurology, 41, 1374–1381.CrossRefGoogle Scholar
Neary, D. & Snowden, J. (1996). Fronto-temporal dementia: Nosology, neuropsychology, and neuropathology. Brain and Cognition, 31, 176–187.CrossRefGoogle Scholar
Neary, D., Snowden, J.S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P.H., Albert, M., Boone, K., Biller, B.L., Cummings, J., & Benson, D.F. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–1554.CrossRefGoogle Scholar
Nebes, R.D., Butters, M.A., Bulsant, B.H., Pollock, B.G., Zmuda, M.D., Houck, P.R., & Reynolds, C.F.I. (2000). Decreased working memory and processing speed mediate cognitive impairment in geriatric depression. Psychological Medicine, 30, 679–691.CrossRefGoogle Scholar
Nebes, R.D., Butters, M.A., Houck, P.R., Zmuda, M.D., Aizenstein, H., Pollock, B.G., Mulsant, B.H., & Reynolds, C.F.I. (2001). Dual-task performance in depressed geriatric patients. Psychiatry Research, 102, 139–151.CrossRefGoogle Scholar
Nelson, L.D., Cicchetti, D., Satz, P., Sowa, M., & Mitrushina, M. (1994). Emotional sequelae of stroke: A longitudinal perspective. Journal of Clinical and Experimental Neuropsychology, 16, 796–806.CrossRefGoogle Scholar
Newmann, J.P. (1989). Aging and depression. Psychology and Aging, 4, 150–165.CrossRefGoogle Scholar
Nobler, M.S., Sackeim, H.A., Prohovnik, I., Moeller, J.R., Mukherjee, S., Schnur, D.B., Prudic, J., & Devanand, D.P. (1994). Regional cerebral blood flow in mood disorders, III. Treatment and clinical response. Archives of General Psychiatry, 51, 884–897.CrossRefGoogle Scholar
O'Brien, J., Perry, R., Barber, R., Gholkar, A., & Thomas, A. (2000). The association between white matter lesions on magnetic resonance imaging and noncognitive symptoms. Annals of New York Academy of Science, 903, 482–489.CrossRefGoogle Scholar
Ongur, D., Drevets, W.C., & Price, J.L. (1998). Glial reduction in the subgenual prefrontal cortex in mood disorders. Proceedings of the National Academy of Science, USA, 95, 13290–13295.CrossRefGoogle Scholar
Ongur, D. & Price, J.L. (2000). The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereberal Cortex, 10, 206–219.CrossRefGoogle Scholar
Osterrieth, P.A. (1944). Le test de copie d'une figure complexe [The Complex Figure Copy Test]. Clinical Neuropsychologist, 7, 9–15.Google Scholar
Pachana, N.A., Boone, K.B., Miller, B.L., Cummings, J.L., & Berman, N. (1996). Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia. Journal of the International Neuropsychological Society, 2, 505–510.CrossRefGoogle Scholar
Palmer, B.W., Boone, K.B., Lesser, I.M., Wohl, M.A., Berman, N., & Miller, B.L. (1996). Neuropsychological deficits among older depressed patients with predominantly psychological or vegetative symptoms. Journal of Affective Disorders, 41, 17–24.CrossRefGoogle Scholar
Pálsson, S., Johannson, B., Berg, S., & Skoog, I. (2000). A population study on the influence of depression on neuropsychological functioning in 85-year-olds. Acta Psychiatrica Scandinavica, 101, 185–193.CrossRefGoogle Scholar
Pasquier, F., Lebert, F., Grymonprez, L., & Petit, H. (1995). Verbal fluency in dementia of frontal lobe type and dementia of Alzheimer type. Journal of Neurology, Neurosurgery, and Psychiatry, 58, 81–84.CrossRefGoogle Scholar
Perry, R.J. & Hodges, J.R. (2000). Differentiating frontal and temporal variant frontotemporal dementia from Alzheimer's disease. Neurology, 54, 2277–2284.CrossRefGoogle Scholar
Peterson, L.R. & Peterson, M.J. (1959). Short-term retention of individual verbal items. Journal of Experimental Psychology, 58, 193–198.CrossRefGoogle Scholar
Rahman, S., Robbins, T.W., & Sahakian, B.J. (2001a). Comparative cognitive neuropsychological studies of frontal lobe function: Implications for therapeutic strategies in frontal variant frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 10 (Suppl. 1), 15–28.Google Scholar
Rahman, S., Sahakian, B.J., Hodges, J.R., Rogers, R.D., & Robbins, T.W. (1999). Specific cognitive deficits in mild frontal variant frontotemporal dementia. Brain, 122, 1469–1493.CrossRefGoogle Scholar
Rahman, S., Sahakian, J., Cardinal, N., Rogers, R., & Robbins, T. (2001b). Decision making and neuropsychiatry. Trends in Cognitive Science, 5, 271–277.Google Scholar
Raji, M.A., Ostir, G.V., Markides, K.S., & Goodwin, J.S. (2002). The interaction of cognitive and emotional status on subsequent physical functioning in older Mexican Americans: Findings from the Hispanic established population for the epidemiologic study of the elderly. Journal of Gerontology, Biological Science and Medical Science, 57, M678–682.CrossRefGoogle Scholar
Rajkowska, G., Miguel-Hidalgo, J.J., Wei, J., Dilley, G., Pittman, S.D., Meltzer, H.Y., Overholseer, J.C., Roth, B.L., & Stockmeier, C.A. (1999). Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biological Psychiatry, 45, 1085–1098.CrossRefGoogle Scholar
Razani, J., Boone, K.B., Miller, B.L., Lee, A., & Sherman, D. (2001). Neuropsychological performance of right- and left-frontotemporal dementia compared to Alzheimer's disease. Journal of International Neuropsychological Society, 7, 468–480.CrossRefGoogle Scholar
Rey, A. (1941). Psychological examination of traumatic encephalopathy. Archives de Psychologie, 28, 286–340.Google Scholar
Rey, A. (1964). L'examen clinique en psychologie [The clinical examination in psychology]. Paris: Presses Universitaires de France.
Robbins, T.W., James, M., Owen, A.M., Sahakian, B.J., McInnes, L., & Rabbitt, P. (1994). Cambridge Neuropsychological Test Automated Battery (CANTAB): A factor analytic study of a large sample of normal elderly volunteers. Dementia, 5, 266–281.CrossRefGoogle Scholar
Robertson, I.H., Ward, T., Ridgeway, V., & Nimmo-Smith, I. (1996). The structure of normal human attention: The Test of Everyday Attention. Journal of International Neuropsychological Society, 2, 525–534.CrossRefGoogle Scholar
Runyon, R.P., Haber, A., Pittenger, D.J., & Coleman, K.A. (1996). Fundamentals of behavioral science (8th ed.). New York: McGraw-Hill Companies, Inc.
Rypma, B. & D'Esposito, M.D. (1999). The roles of prefrontal brain regions in components of working memory: Effects of memory load and individual differences. Proceedings of the National Academy of Sciences, USA, 96, 6558–6563.CrossRefGoogle Scholar
Salloway, S., Malloy, P., Kohn, R., Gillard, E., Duffy, J., Rogg, J., Tung, G., Richardson, E., Thomas, C., & Westlake, R. (1996). MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology, 46, 1567–1574.CrossRefGoogle Scholar
Shallice, T. (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London, 298, 199–209.CrossRefGoogle Scholar
Smith, E.E. & Jonides, J. (1999). Storage and executive processes in the frontal lobes. Science, 283, 1657–1661.CrossRefGoogle Scholar
Snowden, J.S., Neary, D., & Mann, D.M.A. (1996). Fronto-temporal lobar degeneration: Fronto-temporal dementia, progressive aphasia, semantic dementia. New York: Churchill Livingstone.
Spitzer, R.L., Endicott, J., & Robins, E. (1978). Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.CrossRefGoogle Scholar
Spreen, O. & Strauss, E. (1991). A compendium of neuropsychological tests. New York: Oxford University Press.
Steffens, D.C., Byrum, C.E., McQuoid, D.R., Greenberg, D.L., Payne, M.E., Blitchington, T.F., MacFall, J.R., & Krishnan, K.R. (2000). Hippocampal volume in geriatric depression. Biological Psychiatry, 48, 301–309.CrossRefGoogle Scholar
Stek, M.L., Van Exel, E., Van Tilburg, W., Westendorp, R.G., & Beekman, A.T. (2002). The prognosis of depression in old age: Outcome six to eight years after clinical treatment. Aging and Mental Health, 6, 282–285.CrossRefGoogle Scholar
Stroop, J.R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643–662.CrossRefGoogle Scholar
Swainson, R., Hodges, J.R., Galton, C.J., Semple, J., Michael, A., Dunn, B.D., Iddon, J.L., Robbins, T.W., & Sahakian, B.J. (2001). Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks. Dementia and Geriatric Cognitive Disorders, 12, 265–280.CrossRefGoogle Scholar
Tang, Y., Nyengaard, J.R., Pakkenberg, B., & Gundersen, H.J.G. (1997). Age-induced white matter changes in the human brain: A stereological investigation. Neurobiology of Aging, 18, 609–615.CrossRefGoogle Scholar
Trichard, C., Martinot, J.L., Alagille, M., Masure, M.C., Hardy, P., Ginestet, D., & Feline, A. (1995). Time course of prefrontal lobe dysfunction in severely depressed in-patients: A longitudinal neuropsychological study. Psychological Medicine, 25, 79–85.CrossRefGoogle Scholar
Tulving, E. (1977). Context effects in the storage and retrieval of information in man [proceedings]. Psychopharmacological Bulletin, 13, 67–68.Google Scholar
Tulving, E. (1987). Multiple memory systems and consciousness. Human Neurobiology, 6, 67–80.Google Scholar
Visser, P.J., Verhey, F.R., Ponds, R.W., Kester, A., & Jolles, J. (2000). Distinction between preclinical Alzheimer's disease and depression. Journal of the American Geriatric Society, 48, 479–484.CrossRefGoogle Scholar
Warrington, E.K. (1984). Recognition Memory Test. Windsor, UK: NFER-Nelson.
Warrington, E.K. & James, J.J. (1991). The Visual Object and Space Perception Battery. Bury, St. Edmunds, UK: Thames Valley Test Company.
Wechsler, D. (1981). Wechsler Adult Intelligence Scale–Revised manual. New York: The Psychological Corporation.
Wechsler, D. (1987). Wechsler Memory Scale–Revised manual. New York: The Psychological Corporation.
Wells, K.B., Burnam, M.A., Rogers, W., Hays, R., & Camp, P. (1992). The course of depression in adult outpatients. Archives of General Psychiatry, 49, 788–794.CrossRefGoogle Scholar
Yaffe, K., Blackwell, T., Gore, R., Sands, L., Reus, V., & Browner, W.S. (1999). Depressive symptoms and cognitive decline in nondemented elderly women. Archives of General Psychiatry, 56, 425–430.CrossRefGoogle Scholar
Zarahn, E., Aguirre, G., & D'Esposito, M.D. (2000). Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. Cognitive Brain Research, 9, 1–17.Google Scholar