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Neurobehaviors and psychotic symptoms in Alzheimer's disease

Published online by Cambridge University Press:  15 December 2000

JANE S. PAULSEN
Affiliation:
Department of Psychiatry, University of Iowa, Iowa City Department of Neurology, University of Iowa, Iowa City Department of Psychology, University of Iowa, Iowa City
REBECCA E. READY
Affiliation:
Department of Psychiatry, University of Iowa, Iowa City Department of Psychology, University of Iowa, Iowa City
JULIE C. STOUT
Affiliation:
Department of Psychology, University of Indiana
DAVID P. SALMON
Affiliation:
Department of Neurosciences, University of California at San Diego School of Medicine
LEON J. THAL
Affiliation:
Department of Neurosciences, University of California at San Diego School of Medicine San Diego Department of Veterans Affairs Medical Center
IGOR GRANT
Affiliation:
Department of Psychiatry, University of California at San Diego School of Medicine San Diego Department of Veterans Affairs Medical Center
DILIP V. JESTE
Affiliation:
Department of Psychiatry, University of California at San Diego School of Medicine Department of Neurosciences, University of California at San Diego School of Medicine San Diego Department of Veterans Affairs Medical Center

Abstract

Psychotic symptoms are common in Alzheimer's disease (AD) and clinicoanatomical and neuropsychological evidence indicate an association between these symptoms and frontal lobe dysfunction. Neurobehaviors associated with frontal dysfunction were assessed in Alzheimer's disease (AD) patients with (n = 20) and without psychotic symptoms (n = 21) matched for mean age, education, gender, and dementia severity. The Frontal Lobe Personality Scale (FLOPs) was completed by patient caregivers to measure behaviors typically associated with frontal dysfunction. Findings indicated that AD patients with psychotic symptoms exhibited significantly greater neurobehavioral dysfunction (FLOPs M = 130.69, SD = 24.70) than AD patients without psychotic symptoms (FLOPs M = 111.10, SD = 25.83). Subscale analyses indicated that psychotic AD patients were more disinhibited (M = 28.28, SD = 7.54) than patients without psychotic symptoms (M = 20.92, SD = 4.9). Findings are consistent with and contribute to previous neuropsychological and clinicoanatomical research suggesting increased frontal dysfunction in AD with psychotic symptoms and lend additional empirical support to subtyping AD based on the presence of psychotic symptoms. Furthermore, findings provide preliminary evidence indicating which specific type of neurobehavioral abnormalities are related to the presence of distressing psychotic symptoms. (JINS, 2000, 6, 815–820.)

Type
Research Article
Copyright
© 2000 The International Neuropsychological Society

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