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Negative Emotion Interference During a Synonym Matching Task in Pediatric Bipolar Disorder with and without Attention Deficit Hyperactivity Disorder

Published online by Cambridge University Press:  11 February 2013

Alessandra M. Passarotti ,
Jacklynn M. Fitzgerald ,
John A. Sweeney  and
Mani N. Pavuluri
Alessandra M. Passarotti*
Affiliation:
Pediatric Brain Research and Intervention Center, University of Illinois at Chicago, Chicago, Illinois Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois
Jacklynn M. Fitzgerald
Affiliation:
Pediatric Brain Research and Intervention Center, University of Illinois at Chicago, Chicago, Illinois Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois
John A. Sweeney
Affiliation:
University of Texas Southwestern Medical Center, Dallas, Texas
Mani N. Pavuluri
Affiliation:
Pediatric Brain Research and Intervention Center, University of Illinois at Chicago, Chicago, Illinois Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois Colbeth Clinic, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois
*
Correspondence and reprint requests to: Alessandra M. Passarotti, Pediatric Brain Research and Intervention Center, Institute for Juvenile Research, University of Illinois at Chicago, 1747 West Roosevelt Road (M/C 747), Chicago, IL 60608. E-mail: [email protected]
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Abstract

This study examined whether processing of emotional words impairs cognitive performance in acutely ill patients with pediatric bipolar disorder (PBD), with or without comorbid attention-deficit hyperactivity disorder (ADHD), relative to healthy controls (HC). Forty youths with PBD without ADHD, 20 youths with PBD and ADHD, and 29 HC (mean age = 12.97 ± 3.13) performed a Synonym Matching task, where they decided which of two probe words was the synonym of a target word. The three words presented on each trial all had the same emotional valence, which could be negative, positive, or neutral. Relative to HC both PBD groups exhibited worse accuracy for emotional words relative to neutral ones. This effect was greater with negative words and observed regardless of whether PBD patients had comorbid ADHD. In the PBD group without ADHD, manic symptoms correlated negatively with accuracy for negative words, and positively with reaction time (RT) for all word types. Our findings suggest a greater disruptive effect of emotional valence in both PBD groups relative to HC, reflecting the adverse effect of altered emotion processing on cognitive function in PBD. Future studies including an ADHD group will help clarify how ADHD symptoms may affect emotional interference independently of PBD. (JINS, 2013, 19, 1–12)

Keywords

BipolarADHDEmotionAttention biasInterferenceYouths
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 5 , May 2013 , pp. 601 - 612
Copyright
Copyright © The International Neuropsychological Society 2013

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References

Adler, C.M., Delbello, M.P., Mills, N.P., Schmithorst, V., Holland, S., Strakowski, S.M. (2005). Comorbid ADHD is associated with altered patterns of neuronal activation in youth with bipolar disorder performing a simple attention task. Bipolar Disorders, 7(6), 577–588.CrossRefGoogle ScholarPubMed
Adolphs, R. (2003). Is the human amygdala specialized for processing social information? Annals of the New York Academy of Sciences, 985(1), 326–340.CrossRefGoogle ScholarPubMed
American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders IV-TR (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
Annett, M. (1970). A classification of hand preference by association analysis. British Journal of Psychology, 61(3), 303–321.CrossRefGoogle ScholarPubMed
Barkley, R.A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121(1), 65–94.CrossRefGoogle ScholarPubMed
Beck, A.T., Clark, D.A. (1997). An information processing model of anxiety: Automatic and strategic processes. Behaviour Research and Therapy, 35(1), 49–58.CrossRefGoogle ScholarPubMed
Biederman, J., Faraone, S., Mick, E., Wozniak, J., Chen, L., Ouellette, C., Lelon, E. (1996). Attention-deficit hyperactivity disorder and juvenile mania: An overlooked comorbidity? Journal of the American Academy of Child & Adolescent Psychiatry, 35(8), 997–1008.CrossRefGoogle ScholarPubMed
Bishop, S.J., Jenkins, R., Lawrence, A.D. (2007). Neural processing of fearful faces: Effects of anxiety are gated by perceptual capacity limitations. Cerebral Cortex, 17(7), 1595–1603.CrossRefGoogle ScholarPubMed
Bradley, M.M., Lang, P.J. (1999). Affective norms for English words (ANEW): Stimuli, instruction manual and affective ratings. Gainsville, FL: University of Florida Center for Research in Psychophysiology.Google Scholar
Brotman, M.A, Rich, B.A., Schmajuk, M., Reising, M., Monk, C.S., Dickstein, D.P., Leibenluft, E. (2007). Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders. Biological Psychiatry, 61(6), 819–821. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17338904CrossRefGoogle ScholarPubMed
Cardinal, R.N., Parkinson, J.A., Hall, J., Everitt, B.J. (2002). Emotion and motivation: The role of the amygdala, ventral striatum, and prefrontal cortex. Neuroscience & Biobehavioral Reviews, 26(3), 321–352.CrossRefGoogle ScholarPubMed
Compton, R.J., Banich, M.T., Mohanty, A., Milham, M.P., Herrington, J., Miller, G.A., Heller, W. (2003). Paying attention to emotion: An fMRI investigation of cognitive and emotional stroop tasks. Cognitive, Affective, & Behavioral Neuroscience, 3(2), 81–96.CrossRefGoogle ScholarPubMed
Davis, M., Whalen, P.J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6(1), 13–34.CrossRefGoogle ScholarPubMed
Dickenstein, D.P., Garvey, M., Pradella, A.G., Greenstein, D.K., Sharp, W., Xavier Castellanos, F., Leibenluft, E. (2005). Neurologic examination abnormalities in children with bipolar disorder or attention deficit/hyperactivity disorder. Biological Psychiatry, 58, 517–524.CrossRefGoogle Scholar
Doyle, A.E. (2006). Executive functions in attention-deficit/hyperactivity disorder. J Clin Psychiatry, 67(8), 21–26. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16961426Google Scholar
Doyle, A.E., Willcutt, E.G., Seidman, L.J., Biederman, J., Chouinard, V.A., Silva, J., Faraone, S.V. (2005). Attention-deficit/hyperactivity disorder endophenotypes. Biological Psychiatry, 57(11), 1324–1335.CrossRefGoogle ScholarPubMed
DuPaul, G. (1998). ADHD Rating Scale-IV: Checklists, norms, and clinical interpretation. In: Journal of psychoeducational assessment (pp. 172–178). New York: Guilford Press.Google Scholar
Ernst, M., Nelson, E.E., Jazbec, S., McClure, E.B., Monk, C.S., Leibenluft, E., Pine, D.S. (2005). Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and youth. Neuroimage, 25(4), 1279–1291.CrossRefGoogle Scholar
Foland, L.C., Altshuler, L.L., Bookheimer, S.Y., Eisenberger, N., Townsend, J., Thompson, P.M. (2008). Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Research, 162(1), 27–37.CrossRefGoogle ScholarPubMed
Galanter, C.A., Leibenluft, E. (2008). Frontiers between attention deficit hyperactivity disorder and bipolar disorder. Child and Adolescent Psychiatric Clinics of North America, 17, 325–346.CrossRefGoogle ScholarPubMed
Geller, B., Tillman, R., Bolhofner, K., Zimerman, B. (2008). Child bipolar I disorder: Prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome. Archives General Psychiatry, 65(10), 1125–1133.CrossRefGoogle ScholarPubMed
Geller, B., Warner, K., Williams, M., Zimerman, B. (1998). Prepubertal and young adolescent bipolarity versus ADHD: Assessment and validity using the WASH-U-KSADS, CBCL and TRF. Journal of Affective Disorders, 51(2), 93–100.CrossRefGoogle Scholar
Gilhooly, K.J., Logie, R. (1980). Age of acquisition, imagery, concreteness, familiarity and ambiguity measures for 1,944 words. Behavioral Research Methods and Instrumentation, 12(4), 395–427.CrossRefGoogle Scholar
Gorrindo, T., Blair, R.J.R., Budhani, S., Dickstein, D.P., Pine, D.S., Leibenluft, E. (2005). Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. American Journal of Psychiatry, 162(10), 1975–1977.CrossRefGoogle ScholarPubMed
Guyer, A.E., McClure, E.B., Adler, A.D., Brotman, M.A., Rich, B.A., Kimes, A.S., Leibenluft, E. (2007). Specificity of facial expression labeling deficits in childhood psychopathology. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 48(9), 863–871.CrossRefGoogle ScholarPubMed
Hakamata, Y., Lissek, S., Bar-Haim, Y., Britton, J.C., Fox, N.A., Leibenluft, E., Pine, D.S. (2010). Attention bias modification treatment: A meta-analysis toward the establishment of novel treatment for anxiety. Biological Psychiatry, 68(11), 982–990.CrossRefGoogle ScholarPubMed
Holmboe, K., Elsabbagh, M., Volein, A., Tucker, L.A., Baron-Cohen, S., Bolton, P., Johnson, M.H. (2010). Frontal cortex functioning in the infant broader autism phenotype. Infant Behavior & Development, 33(4), 482–491.CrossRefGoogle ScholarPubMed
Jabben, N., Arts, B., Jongen, E.M., Smulders, F.T., van Os, J., Krabbendam, L. (2012). Cognitive processes and attitudes in bipolar disorder: A study into personality, dysfunctional attitudes and attention bias in patients with bipolar disorder and their relatives. Journal of Affective Disorders, 143, 265–268.CrossRefGoogle ScholarPubMed
Jacobs, R.H., Pavuluri, M.N., Schenkel, L.S., Palmer, A., Shah, K., Vemuri, D., Little, D.M. (2011). Negative emotion impacts memory for verbal discourse in pediatric bipolar disorder. Bipolar Disorders, 13(3), 287–293.CrossRefGoogle ScholarPubMed
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., Ryan, N. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 980–988.CrossRefGoogle ScholarPubMed
Kim, E.Y., Miklowitz, D.J. (2002). Childhood mania, attention deficit hyperactivity disorder and conduct disorder: A critical review of diagnostic dilemmas. Bipolar Disorders, 4(4), 215–225.CrossRefGoogle ScholarPubMed
Klein, G. (1964). Semantic power measured through the interference of words with color-naming. American Journal of Psychology, 77(4), 576–588.CrossRefGoogle ScholarPubMed
Kucera, H., Francis, W.N. (1967). Computational Analysis of Present-Day American English. Statistics. Providence, RI: Brown University Press.Google Scholar
Lang, P., Bradley, M., Cuthbert, B. 1997. International affective picture system (IAPS): Technical manual and affective ratings. NIMH Center for the Study of Emotion and Attention. University of Florida, Center for Research in Psychophysiology.Google Scholar
Leibenluft, E., Rich, B.A., Vinton, D.T., Nelson, E.E., Fromm, S.J., Berghorst, L., Pine, D.S. (2007). Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. The American Journal of Psychiatry, 164(1), 52–60.CrossRefGoogle ScholarPubMed
Lobue, V., DeLoache, J. (2008). Detecting the snake in the grass: Attention to fear-relevant stimuli by adults and young children. Psychological Science, 19(3), 284–289.CrossRefGoogle ScholarPubMed
March, J.S. (2010). Attention bias modification training and the new interventions research. Biological Psychiatry, 68(11), 978–979.CrossRefGoogle ScholarPubMed
McClure, E.B., Monk, C.S., Nelson, E.E., Parrish, J.M., Adler, A., Blair, R.J., Pine, D.S. (2007). Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Archives of General Psychiatry, 64(1), 97–106.CrossRefGoogle ScholarPubMed
McClure, E.B., Treland, J.E., Snow, J., Schmajuk, M., Dickstein, D.P., Towbin, K.E., Leibenluft, E. (2005). Deficits in social cognition and response flexibility in pediatric bipolar disorder. American Journal Psychiatry, 162(9), 1644–1651.CrossRefGoogle ScholarPubMed
Mogg, K., Bradley, B.P. (1998). A cognitive-motivational analysis of anxiety. Behavioral Research and Therapy, 36, 809–848.CrossRefGoogle ScholarPubMed
Monk, C.S., Nelson, E.E., McClure, E.B., Mogg, K., Bradley, B.P., Leibenluft, E., Pine, D.S. (2006). Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in youth with generalized anxiety disorder. American Journal of Psychiatry, 163(6), 1091–1097.CrossRefGoogle ScholarPubMed
Nigg, J.T., Goldsmith, H.H., Sachek, J. (2004). Temperament and attention deficit hyperactivity disorder: The development of a multiple pathway model. Journal of Clinical Child & Adolescent Psychology, 33, 42–53.CrossRefGoogle ScholarPubMed
Passarotti, A.M., Pavuluri, M.N. (2011). Brain functional domains inform the therapeutical interventions in Attention-deficit/hyperactivity Disorder and Pediatric Bipolar Disorder. Expert Review of Neurotherapeutics, 11(6), 897–914.CrossRefGoogle ScholarPubMed
Passarotti, A.M., Sweeney, J.A., Pavuluri, M.N. (2010a). Emotion processing influences working memory circuits in pediatric bipolar disorder and attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 49(10), 1064–1080.CrossRefGoogle ScholarPubMed
Passarotti, A.M., Sweeney, J.A., Pavuluri, M.N. (2010b). Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder. Journal of the International Neuropsychological Society, 16(1), 106–117.CrossRefGoogle ScholarPubMed
Passarotti, A.M., Sweeney, J.A., Pavuluri, M.N. (2010c). Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder. Psychiatry Research: Neuroimaging, 181(1), 36–43.CrossRefGoogle ScholarPubMed
Passarotti, A.M., Sweeney, J.A., Pavuluri, M.N. (2011). Fronto-limbic dysfunction in mania pre-treatment and persistent amygdala over-activity post-treatment in pediatric bipolar disorder. Psychopharmacology, 216(4), 485–499.CrossRefGoogle ScholarPubMed
Pavuluri, M.N., Graczyk, P.A., Henry, D.B., Carbray, J.A., Heidenreich, J., Miklowitz, D. (2004). Child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: Development and preliminary results. Journal of the American Academy of Child & Adolescent Psychiatry, 43(5), 528–537.CrossRefGoogle ScholarPubMed
Pavuluri, M.N., O'Connor, M.M., Harral, E., Sweeney, J.A. (2007). Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biological Psychiatry, 62(2), 158–167.CrossRefGoogle ScholarPubMed
Pavuluri, M.N., O'Connor, M.M., Harral, E.M., Sweeney, J.A. (2008). An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Research, 162(3), 244–255.CrossRefGoogle ScholarPubMed
Pavuluri, M.N., Passarotti, A.M. (2008). Neural bases of emotional processing in pediatric bipolar disorder. Expert Review of Neurotherapeutics, 8(9), 1381–1387.CrossRefGoogle ScholarPubMed
Pavuluri, M.N., Schenkel, L.S., Aryal, S., Harral, E.M., Hill, S.K., Herbener, E.S., Sweeney, J.A. (2006). Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients. The American Journal of Psychiatry, 163(2), 286–293.CrossRefGoogle ScholarPubMed
Pavuluri, M.N., West, A., Hill, S.K., Jindal, K., Sweeney, J.A. (2009). Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. Journal of the American Academy of Child & Adolescent Psychiatry, 48(3), 299–307.CrossRefGoogle ScholarPubMed
Pine, D.S., Helfinstein, S.M., Bar-Haim, Y., Nelson, E., Fox, N.A. (2009). Challenges in developing novel treatments for disorders: lessons from research on anxiety. Neuropsychopharmacology, 34(1), 213–228.CrossRefGoogle ScholarPubMed
Pine, D.S., Mogg, K., Bradley, B.P., Montgomery, L., Monk, C.S., McClure, E., Kaufman, J. (2005). Attention bias to threat in maltreated children: Implications for vulnerability to stress-related psychopathology. American Journal of Psychiatry, 162(2), 291–296.CrossRefGoogle ScholarPubMed
Pizzagalli, D.A., Goetz, E., Ostacher, M., Iosifescu, D.V., Perlis, R.H. (2008). Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task. Biological Psychiatry, 64(2), 162–168.CrossRefGoogle Scholar
Posner, J., Russel, J.A., Gerber, A., Gorman, D., Colibazzi, T., Yu, S., Peterson, B. (2009). The neurophysiological bases of emotion: An fMRI study of affective circumplex using emotion-denoting words. Human Brain Mapping, 30(3), 883–895.CrossRefGoogle ScholarPubMed
Poznanski, E., Grossman, J., Buchsbaum, Y., Banegas, M., Freeman, L., Gibbons, R. (1984). Preliminary studies of the reliability validity of the children's depression rating scale. Journal of the American Academy of Child Psychiatry, 23(2), 191–197.CrossRefGoogle ScholarPubMed
Psychological Corporation. (1999). Wechsler Abbreviated Scale of Intelligence (WASI). San Antonio, TX: Harcourt Brace & Company.Google Scholar
Rapport, L.J., Friedman, S., Tzelepis, A., VanVoorhis, A. (2002). Experienced emotion and affect recognition in adult attention-deficit hyperactitiy disorder. Neuropsychology, 16, 102–110.CrossRefGoogle ScholarPubMed
Rich, B.A., Brotman, M., Dickstein, D., Mitchell, D.V., Blair, R.J.R., Leibenluft, E. (2010). Deficits in attention to emotional stimuli distinguish youth with severe mood dysregulation from youth with bipolar disorder. Journal of Abnormal Child Psychology, 38(5), 695–706.CrossRefGoogle ScholarPubMed
Rich, B.A., Grimley, M.E., Schmajuk, M., Blair, K.S., Blair, R.J.R., Leibenluft, E. (2008). Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation. Development and Psychopathology, 20(2), 529–546.CrossRefGoogle ScholarPubMed
Rich, B.A., Schmajuk, M., Perez-Edgar, K.E., Pine, D.S., Fox, N.A., Leibenluft, E. (2005). The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder. Biological Psychiatry, 58(7), 532–539.CrossRefGoogle ScholarPubMed
Rich, B.A., Vinton, D.A., Roberson-Nay, R., Hommer, R.E., Berghorst, L.H., McClure, E.B., Leibenluft, E. (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proceedings of the National Academy of Sciences of the United States of America, 103(23), 8900–8905.CrossRefGoogle ScholarPubMed
Rothman, K.J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1, 43–46.CrossRefGoogle ScholarPubMed
Roy, A.K., Vasa, R.A., Bruck, M., Mogg, K., Bradley, B.P., Sweeney, J.A., Pine, D.S. (2008). Attention Bias toward threat in pediatric anxiety disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 47(10), 1189–1196.CrossRefGoogle ScholarPubMed
Rucklidge, J.J. (2006). Impact of ADHD on the neurocognitive functioning of youth with bipolar disorder. Biological Psychiatry, 60, 921–928.CrossRefGoogle ScholarPubMed
Schneider, W., Dumais, S.T., Shiffrin, R.M. (1984). Automatic and control processing and attention. In R. Parasuraman & D. R. Davies (Eds.), Varieties of attention (pp. 1–25). Orlando, FL: Academic Press.Google Scholar
Shenkel, L.S., Passarotti, A.M., Sweeney, J.A., Pavuluri, M.N. (2012). Negative emotion impairs working memory in pediatric patients with bipolar disorder type I. Psychological Medicine, 8, 1–11.Google Scholar
Shenkel, L.S., Pavuluri, M.N., Herbener, E.S., Harral, E.M., Sweeney, J.A. (2007). Facial emotion processing in acutely ill and euthymic patients with pediatric bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 46(8), 1070–1079.CrossRefGoogle Scholar
Singh, M.K., Chang, K.D., Mazaika, P., Garrett, A., Adleman, N., Kelley, R., Reiss, A. (2010). Neural correlates of response inhibition in pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 20(1), 15–24.CrossRefGoogle ScholarPubMed
Solé, B., Martínez-Arán, A., Torrent, C., Bonnin, C.M., Reinares, M., Popovic, D., Vieta, E. (2011). Are bipolar II patients cognitively impaired? A systematic review. Psychological Medicine, 41(9), 1791–1803.CrossRefGoogle ScholarPubMed
Stormark, K.M., Nordby, H., Hugdahl, K. (1995). Attentional shifts to emotionally charged cues: Behavioral and ERP data. Cognition and Emotion, 9(5), 507–523.CrossRefGoogle Scholar
Vuilleumier, P. (2005). How brains beware: Neural mechanisms of emotional attention. Trends in Cognitive Sciences, 9(12), 585–594.CrossRefGoogle ScholarPubMed
West, A.E., Pavuluri, M.N. (2009). Psychosocial treatments for childhood and adolescent bipolar disorder. Child and Adolescent Psychiatric Clinics of North America, 18(2), 471–482.CrossRefGoogle ScholarPubMed
Williams, J.M., Mathews, A., MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120(1), 3–24.CrossRefGoogle ScholarPubMed
Young, R.C., Biggs, J.T., Ziegler, V.E., Meyer, D. (1978). A rating scale for mania: Reliability, validity, and sensitivity. British Journal of Psychiatry, 133(5), 429–435.CrossRefGoogle ScholarPubMed