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The Multilingual Naming Test (MINT) as a Measure of Picture Naming Ability in Alzheimer’s Disease

Published online by Cambridge University Press:  28 June 2019

Alena Stasenko Open the ORCID record for Alena Stasenko [Opens in a new window] ,
Diane M. Jacobs ,
David P. Salmon  and
Tamar H. Gollan
Alena Stasenko
Affiliation:
San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, USA
Diane M. Jacobs
Affiliation:
Department of Neurosciences, Shiley-Marcos Alzheimer’s Disease Research Center, University of California, 9444 Medical Center Dr #1-100, La Jolla, CA 92037, USA
David P. Salmon
Affiliation:
Department of Neurosciences, Shiley-Marcos Alzheimer’s Disease Research Center, University of California, 9444 Medical Center Dr #1-100, La Jolla, CA 92037, USA
Tamar H. Gollan*
Affiliation:
Department of Psychiatry, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA
*
*Correspondence and reprint requests to: Tamar H. Gollan, Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. E-mail: [email protected]
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Abstract

Objective:

The present study investigated the ability of the Multilingual Naming Test (MINT), a picture naming test recently added to the National Alzheimer’s Coordinating Center’s (NACC) Uniform Data Set neuropsychological test battery, to detect naming impairment (i.e., dysnomia) across stages of Alzheimer’s disease (AD).

Method:

Data from the initial administration of the MINT were obtained on NACC participants who were cognitively normal (N = 3,981) or diagnosed with mild cognitive impairment (N = 852) or dementia (N = 1,148) with presumed etiology of AD. Dementia severity was rated using the Clinical Dementia Rating (CDR) scale.

Results:

Cross-sectional multiple regression analyses revealed significant effects of diagnostic group, sex, education, age, and race on naming scores. Planned comparisons collapsing across age and education groups revealed significant group differences in naming scores across levels of dementia severity. ROC curve analyses showed good diagnostic accuracy of MINT scores for distinguishing cognitively normal controls from AD dementia, but not from MCI. Within the cognitively normal group, there was a robust interaction between age and education such that naming scores exhibited the most precipitous drop across age groups for the least educated participants. Additionally, education effects were stronger in African-Americans than in Whites (a race-by-education interaction), and race effects were stronger in older than in younger age groups (a race-by-age interaction).

Conclusions:

The MINT successfully detects naming deficits at different levels of cognitive impairment in patients with MCI or AD dementia, but comparison to age, sex, race, and education-corrected norms to determine impairment is essential.

Keywords

NamingMINTDysnomiaAlzheimer’s diseaseMCI
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 25 , Issue 8 , September 2019 , pp. 821 - 833
Copyright
Copyright © INS. Published by Cambridge University Press, 2019. 

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