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Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods

Published online by Cambridge University Press:  20 March 2007

THOMAS T. LIU  and
GREGORY G. BROWN
THOMAS T. LIU
Affiliation:
Department of Radiology, University of California San Diego, San Diego, California
GREGORY G. BROWN
Affiliation:
Psychology Service, VA San Diego Healthcare System, San Diego, California Department of Psychiatry, University of California San Diego, San Diego, California
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Abstract

Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) method that provides a highly repeatable quantitative measure of cerebral blood flow (CBF). As compared to the more commonly used blood oxygenation level dependent (BOLD) contrast-based methods, ASL techniques measure a more biologically specific correlate of neural activity, with the potential for more accurate estimation of the location and magnitude of neural function. Recent advances in acquisition and analysis methods have improved the somewhat limited sensitivity of ASL to perfusion changes associated with neural activity. In addition, ASL perfusion measures are insensitive to the low-frequency fluctuations commonly observed in BOLD experiments and can make use of imaging sequences that are less sensitive than BOLD contrast to signal loss caused by magnetic susceptibility effects. ASL measures of perfusion can aid in the interpretation of the BOLD signal change and, when combined with BOLD, can measure the change in oxygen utilization accompanying changes in behavioral state. Whether used alone to probe neural activity or in combination with BOLD techniques, ASL methods are contributing to the field's understanding of healthy and disordered brain function. (JINS, 2007, 13, 517–525.)

Keywords

fMRI; Cerebrovascular circulationCerebral cortexBrainRegional blood flowMicrocirculation
Type
CRITICAL REVIEW
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 3 , May 2007 , pp. 517 - 525
Copyright
© 2007 The International Neuropsychological Society

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