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Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer’s disease

Published online by Cambridge University Press:  11 December 2009

SHARON X. XIE*
Affiliation:
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
DAVID J. LIBON
Affiliation:
Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania
XINGMEI WANG
Affiliation:
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
LAUREN MASSIMO
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
PEACHIE MOORE
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
LUISA VESELY
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
ALEA KHAN
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
ANJAN CHATTERJEE
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
H. BRANCH COSLETT
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
HOWARD I. HURTIG
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
TSAO-WEI LIANG
Affiliation:
Department of Neurology, Thomas Jefferson Medical College, Philadelphia, Pennsylvania
MURRAY GROSSMAN
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
*
*Correspondence and reprint requests to: Sharon X. Xie, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 618 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021. E-mail: [email protected]

Abstract

The longitudinal assessment of episodic and semantic memory was obtained from 236 patients diagnosed with Alzheimer’s disease (AD, n = 128) and with frontotemporal lobar degeneration (FTLD, n = 108), including patients with a social comportment/dysexecutive (SOC/EXEC) disorder, progressive nonfluent aphasia (PNFA), semantic dementia (SemD), and corticobasal syndrome (CBS). At the initial assessment, AD patients obtained a lower score on the delayed free recall test than other patients. Longitudinal analyses for delayed free recall found converging performance, with all patients reaching the same level of impairment as AD patients. On the initial evaluation for delayed recognition, AD patients also obtained lower scores than other groups. Longitudinal analyses for delayed recognition test performance found that AD patients consistently produced lower scores than other groups and no convergence between AD and other dementia groups was seen. For semantic memory, there were no initial between-group differences. However, longitudinal analyses for semantic memory revealed group differences over illness duration, with worse performance for SemD versus AD, PNFA, SOC/EXEC, and CBS patients. These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype. (JINS, 2010, 16, 278–286.)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 2009

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References

REFERENCES

Arnold, S.E., Hyman, B.T., Flory, J., Damasio, A., & Van Hoesen, G.W. (1991). The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease. Cerebral Cortex, 1, 103116.CrossRefGoogle ScholarPubMed
Blair, M., Marczinski, C.A., Davis-Faroque, N., & Kertesz, A. (2007). A longitudinal study of language decline in Alzheimer’s disease and frontotemporal dementia. Journal of the International Neuropsychological Society, 13, 237245.CrossRefGoogle ScholarPubMed
Cabeza, R., Ciaramelli, E., Olson, I.R., & Moscovitch, M. (2008). The parietal cortex and episodic memory: An attentional account. Nature Review Neuroscience, 9, 613625.CrossRefGoogle ScholarPubMed
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1974). ”Mini-mental state”: A practical method for grading the mental state of patients for a clinician. Journal of Psychiatric Residency, 12, 189198.CrossRefGoogle Scholar
Forman, M.S., Farmer, J., Johnson, J.K., Clark, C.M., Arnold, S.E., Coslett, H.B., et al. (2006). Frontotemporal dementia: Clinicopathological correlations. Annals of Neurology, 59, 952962.CrossRefGoogle ScholarPubMed
Grossman, M., & Ash, S. (2004). Primary progressive aphasia: A review. Neurocase, 10, 318.CrossRefGoogle ScholarPubMed
Grossman, M., & Koenig, P. (2007). Process and content in semantic memory. In Hart, J. Jr. & Kraut, M.A. (Eds.), Neural Basis of Semantic Memory. Cambridge, UK: Cambridge University Press.Google Scholar
Grossman, M., Libon, D.J., Forman, M.S., Wood, E.M., Moore, P., Farmer, J., et al. (2007). Distinct neuropsychological profiles in pathologically-defined patients with Frontotemporal lobe dementia. Archives of Neurology, 64, 16011609.CrossRefGoogle Scholar
Grossman, M., D’Esposito, M., Hughes, E., Onishi, K., Biassou, N., White-Devine, T., et al. (1996). Language comprehension profiles in Alzheimer’s disease, multi-infarct dementia, and frontotemporal degeneration. Neurology, 47, 183189.CrossRefGoogle ScholarPubMed
Grossman, M., Payer, F., Onishi, K., White-Devine, T., Morrison, D., D’Esposito, M., et al. (1997). Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 63, 152158.CrossRefGoogle ScholarPubMed
Grossman, M., Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., et al. (2008). Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology, 70, 20362045.CrossRefGoogle ScholarPubMed
Kertesz, A., Davidson, W., & Fox, H. (1997). Frontal behavioral inventory: Diagnostic criteria for frontal lobe dementia. Canadian Journal of Neuroscience, 24, 2936.Google ScholarPubMed
Kertesz, A., Davidson, W., & Munoz, D.G. (1999). Clinical and pathological overlap between frontotemporal dementia, primary progressive aphasia, and corticobasal degeneration: The Pick Complex. Dementia and Geriatric Cognitive Disorders, 10(Suppl. 1), 4649.CrossRefGoogle ScholarPubMed
Kertesz, A., Martinez-Lage, P., Davidson, W., & Munoz, D.G. (2000). The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology, 55, 13681375.CrossRefGoogle ScholarPubMed
Kertesz, A., McMonagle, P., Blair, M., Davidson, W., & Munoz, D.G. (2005). The evolution and pathology of frontotemporal dementia. Brain, 128, 19962005.CrossRefGoogle ScholarPubMed
Kramer, J.H., Jurik, J., Sha, S.J., Rankin, K.P., Rosen, H.J., Johnson, J.K., et al. (2003). Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cognitive and Behavioral Neurology, 16, 211218.CrossRefGoogle ScholarPubMed
Laird, N.M., & Ware, J.H. (1982). Random-effects models for longitudinal data. Biometrics, 38, 963974.CrossRefGoogle ScholarPubMed
Lepage, M., Ghaffer, O., Nyberg, L., & Tulving, E. (2002). Prefrontal cortex and episodic retrieval mode. Proceedings of the National Academy of Sciences of the United States of America, 28, 506511.Google Scholar
Libon, D.J., Massimo, L., Moore, P., Coslett, H.B., Chatterjee, A., Aguirre, G., et al. (2007). The Philadelphia Brief Assessment of Cognition (PBAC): A brief neuropsychological protocol that distinguishes frontotemporal dementia from Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 24, 441447.CrossRefGoogle Scholar
Libon, D.J., Xie, S.X., Moore, P., Farmer, J., Antani, S., McCawley, G., et al. (2007). Patterns of neuropsychological impairment associated with frontotemporal dementia: A factor analytic study. Neurology, 68, 368375.CrossRefGoogle Scholar
Libon, D.J., Xie, S.X., Wang, X., Massimo, L., Moore, P., Vesely, L., et al. (2009). Neuropsychological decline in frontotemporal lobe dementia: A longitudinal analysis. Neuropsychology, 23, 337346.CrossRefGoogle ScholarPubMed
Lund and Manchester Groups. (1994). Clinical and neuropathological criteria for frontotemporal dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 57, 416418.CrossRefGoogle Scholar
Marczinski, C.A., Davidson, W., & Kertesz, A. (2004). A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia. Cognitive and Behavioral Neurology, 17, 185190.Google ScholarPubMed
Martin, A. (2007). The representation of object concepts in the brain. Annual Review of Psychology, 58, 2845.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadian, E.M. (1984). Clinical diagnosis of Alzheimer’s disease: Report on the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology, 34, 939944.CrossRefGoogle ScholarPubMed
McKhann, G., Trojanowski, J.Q., Grossman, M., Miller, B.L., Dickson, D., & Albert, M. (2001). Clinical and pathological diagnosis of frontotemporal dementia: Report of a work group on frontotemporal dementia and Pick’s disease. Archives of Neurology, 58, 18031809.CrossRefGoogle Scholar
Morris, J.C., Heyman, A., Mohs, R.C., Hughes, J.P., van Belle, G., Fillenbaum, G., et al. (1989). The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology, 39, 11591165.Google Scholar
Moscovitch, M., Rosenbaum, R.S., Gilboa, A., Addis, D.R., Westmacott, R., Grady, C., et al. (2005). Functional neuroanatomy of remote episodic, semantic, and spatial memory: A unified account based on multiple trace theory. Journal of Anatomy, 207, 3566.CrossRefGoogle ScholarPubMed
Murray, R., Neumann, M., Forman, M.S., Farmer, J., Massimo, L., Rice, A., et al. (2007). Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology, 68, 12741283.CrossRefGoogle ScholarPubMed
Neary, D., Snowden, J.S., Gustafson, L., Passant, U., Stuss, D., Black, S., et al. (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51, 15461554.CrossRefGoogle ScholarPubMed
Rascovsky, K., Salmon, D.P., Ho, G.J., Galasko, D., Peavy, G.M., Hansen, L.A., et al. (2002). Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD. Neurology, 58, 18011808.CrossRefGoogle ScholarPubMed
Rascovsky, K., Salmon, D.P., Hansen, L.A., Thal, L.J., & Galasko, D. (2007). Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer’s disease. Neuropsychology, 21, 2030.CrossRefGoogle ScholarPubMed
Shapiro, S.S., & Wilk, M.B. (1965). An analysis of variance test for normality (complete samples). Biometrika, 52, 591611.CrossRefGoogle Scholar
Snowden, J.S., Griffiths, H.L., & Neary, D. (1996). Semantic-episodic memory interactions in semantic dementia: Implications for retrograde memory function. Cognitive Neuropsychology, 13, 11011137.CrossRefGoogle Scholar
Söderlund, H., Black, S.E., Miller, B.L., Freedman, M., & Levine, B. (2008). Episodic memory and regional atrophy in frontotemporal lobar degeneration. Neuropsychologia, 46, 127136.CrossRefGoogle ScholarPubMed
Thompson-Schill, S.L., D’Esposito, M., Aguirre, G., & Farah, M.J. (1997). Role of left inferior prefrontal cortex in retrieval of semantic knowledge: A reevaluation. Proceedings of the National Academy of Sciences of the United States of America, 94, 1479214797.CrossRefGoogle ScholarPubMed