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Influence of APOE Status on Lexical–Semantic Skills in Mild Cognitive Impairment

Published online by Cambridge University Press:  17 March 2011

Roberta Biundo ,
Simona Gardini ,
Paolo Caffarra ,
Letizia Concari ,
Davide Martorana ,
Tauro Maria Neri ,
Michael F. Shanks  and
Annalena Venneri
Roberta Biundo
Affiliation:
Clinical Neuroscience Centre, University of Hull, Hull, United Kingdom
Simona Gardini
Affiliation:
Clinical Neuroscience Centre, University of Hull, Hull, United Kingdom Department of Neuroscience, University of Parma, Parma, Italy
Paolo Caffarra
Affiliation:
Clinical Neuroscience Centre, University of Hull, Hull, United Kingdom Department of Neuroscience, University of Parma, Parma, Italy
Letizia Concari
Affiliation:
Department of Neuroscience, University of Parma, Parma, Italy
Davide Martorana
Affiliation:
Molecular Genetics Unit, Parma University-Hospital, Parma, Italy
Tauro Maria Neri
Affiliation:
Molecular Genetics Unit, Parma University-Hospital, Parma, Italy
Michael F. Shanks
Affiliation:
Clinical Neuroscience Centre, University of Hull, Hull, United Kingdom
Annalena Venneri*
Affiliation:
Clinical Neuroscience Centre, University of Hull, Hull, United Kingdom S. Camillo Hospital (I.R.C.C.S), Venice, Italy
*
Correspondence and reprint requests to: Annalena Venneri, Clinical Neuroscience Centre, University of Hull, Cottingham Road, Hull HU6 7RX, England. E-mail: [email protected]
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Abstract

This study characterized the relationship between apolipoprotein E (APOE) status and residual semantic abilities in amnestic mild cognitive impairment (MCI). APOE status (ε4 carrier/non ε4 carrier) was determined in 30 amnestic MCIs and in 22 healthy matched non ε4 carrier controls. The lexical characteristics (age of acquisition, typicality, familiarity) of words produced in a category fluency task were determined. MCIs produced fewer words than controls and these were also earlier acquired and more familiar. The words produced by MCI ε4 carriers were earlier acquired than those of non ε4 carriers. Analyses limited to the first 10 words produced by patients and controls showed similar findings and also revealed that MCI subgroups retrieved first more typical words than controls. Follow up showed higher conversion to Alzheimer's disease (AD) in MCI ε4 carriers than in non ε4 carriers. These findings show that a significant proportion of phenotype variability in performance on category fluency in people at increased AD risk is influenced by genetic factors. These findings explain why category fluency deficits, together with episodic memory deficits, are the only consistent early deficits in MCI patients who convert to AD. (JINS, 2011, 17, 423–430)

Keywords

APOEAlzheimer's diseaseDementiaAge of acquisitionLexicalSemantic
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 3 , May 2011 , pp. 423 - 430
Copyright
Copyright © The International Neuropsychological Society 2011

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