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Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks

Published online by Cambridge University Press:  01 May 2009

MARY M. MACHULDA ,
MATTHEW L. SENJEM ,
STEPHEN D. WEIGAND ,
GLENN E. SMITH ,
ROBERT J. IVNIK ,
BRAD F. BOEVE ,
DAVID S. KNOPMAN ,
RONALD C. PETERSEN  and
CLIFFORD R. JACK JR
MARY M. MACHULDA*
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
MATTHEW L. SENJEM
Affiliation:
Department of Information Technology, Mayo Clinic, Rochester, Minnesota
STEPHEN D. WEIGAND
Affiliation:
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
GLENN E. SMITH
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
ROBERT J. IVNIK
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
BRAD F. BOEVE
Affiliation:
Department of Neurology, Mayo Clinic, Rochester, Minnesota
DAVID S. KNOPMAN
Affiliation:
Department of Neurology, Mayo Clinic, Rochester, Minnesota
RONALD C. PETERSEN
Affiliation:
Department of Neurology, Mayo Clinic, Rochester, Minnesota
CLIFFORD R. JACK JR
Affiliation:
Department of Radiology, Mayo Clinic, Rochester, Minnesota
*
*Correspondence and reprint requests to: Mary M. Machulda, Department of Psychiatry and Psychology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905. E-mail: [email protected]
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Abstract

Functional magnetic resonance imaging (fMRI) shows changes in multiple regions in amnestic mild cognitive impairment (aMCI). The concept of MCI recently evolved to include nonamnestic syndromes, so little is known about fMRI changes in these individuals. This study investigated activation during visual complex scene encoding and recognition in 29 cognitively normal (CN) elderly, 19 individuals with aMCI, and 12 individuals with nonamnestic MCI (naMCI). During encoding, CN activated an extensive network that included bilateral occipital–parietal–temporal cortex; precuneus; posterior cingulate; thalamus; insula; and medial, anterior, and lateral frontal regions. Amnestic MCI activated an anatomic subset of these regions. Non-amnestic MCI activated an even smaller anatomic subset. During recognition, CN activated the same regions observed during encoding except the precuneus. Both MCI groups again activated a subset of the regions activated by CN. During encoding, CN had greater activation than aMCI and naMCI in bilateral temporoparietal and frontal regions. During recognition, CN had greater activation than aMCI in predominantly temporoparietal regions bilaterally, while CN had greater activation than naMCI in larger areas involving bilateral temporoparietal and frontal regions. The diminished parietal and frontal activation in naMCI may reflect compromised ability to perform nonmemory (i.e., attention/executive, visuospatial function) components of the task. (JINS, 2009, 15, 372–382.)

Keywords

Magnetic resonance imagingNeuropsychologyFrontal lobeParietal lobeTemporal lobeDementia
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 3 , May 2009 , pp. 372 - 382
Copyright
Copyright © The International Neuropsychological Society 2009

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