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Frontal Assessment Battery in Parkinson’s Disease: Validity and Morphological Correlates

Published online by Cambridge University Press:  18 July 2017

Ondrej Bezdicek ,
Filip Růžička ,
Adela Fendrych Mazancova ,
Jan Roth ,
Pavel Dušek ,
Karsten Mueller ,
Evžen Růžička  and
Robert Jech
Ondrej Bezdicek*
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
Filip Růžička
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
Adela Fendrych Mazancova
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
Jan Roth
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
Pavel Dušek
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
Karsten Mueller
Affiliation:
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Evžen Růžička
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
Robert Jech
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic
*
Correspondence and reprint requests to: Ondrej Bezdicek, Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Kateřinská 30, 128 21 Praha 2, Czech Republic. E-mail: [email protected]
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Abstract

Objectives: Executive dysfunction is a common feature in Parkinson’s disease (PD). However, there is a lack of brief validated instruments for executive dysfunction in PD. Methods: The aim of the present study was to assess the relation of Frontal Assessment Battery (FAB) scores to age and education, to verify the utility of FAB in the evaluation of executive dysfunction in PD and to differentiate between controls (n=41), PD patients with normal cognition (PD-NC; n=41; Hoehn and Yahr stages 2–3) and PD with mild cognitive impairment (PD-MCI; n=32; Hoehn and Yahr stages 2–3). In addition, we studied the relation between voxel-based morphometric (VBM) data and FAB results in PD. Results: We found that FAB scores are significantly related to age and education. The FAB has shown discriminative validity for the differentiation of PD-MCI from PD-NC and controls (area under the curve >.80). Also, the VBM analysis revealed lower FAB scores are specifically related to lower gray matter density in the right ventromedial prefrontal areas and precuneus. Conclusions: The FAB can be recommended as a valid instrument for PD-MCI Level I screening. FAB is sensitive to frontal lobe involvement in PD as reflected by lower gray matter density in prefrontal areas. (JINS, 2017, 23, 675–684)

Keywords

Executive functionsFABMild cognitive impairmentParkinson’s diseaseSPMVBM
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 23 , Issue 8 , September 2017 , pp. 675 - 684
Copyright
Copyright © The International Neuropsychological Society 2017 

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