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fMRI reveals alteration of spatial working memory networks across adolescence

Published online by Cambridge University Press:  26 August 2005

ALECIA D. SCHWEINSBURG ,
BONNIE J. NAGEL  and
SUSAN F. TAPERT
ALECIA D. SCHWEINSBURG
Affiliation:
Department of Psychology, University of California, San Diego, La Jolla, California
BONNIE J. NAGEL
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California Veterans Medical Research Foundation, San Diego, California
SUSAN F. TAPERT
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California VA San Diego Healthcare System, San Diego, California Veterans Medical Research Foundation, San Diego, California
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Abstract

Recent studies have described neuromaturation and cognitive development across the lifespan, yet few neuroimaging studies have investigated task-related alterations in brain activity during adolescence. We used functional magnetic resonance imaging (fMRI) to examine brain response to a spatial working memory (SWM) task in 49 typically developing adolescents (25 females and 24 males; ages 12–17). No gender or age differences were found for task performance during SWM. However, age was positively associated with SWM brain response in left prefrontal and bilateral inferior posterior parietal regions. Age was negatively associated with SWM activation in bilateral superior parietal cortex. Gender was significantly associated with SWM response; females demonstrated diminished anterior cingulate activation and males demonstrated greater response in frontopolar cortex than females. Our findings indicate that the frontal and parietal neural networks involved in spatial working memory change over the adolescent age range and are further influenced by gender. These changes may represent evolving mnemonic strategies subserved by ongoing adolescent brain development. (JINS, 2005, 11, 631–644.)

Keywords

AdolescentFunctional MRICognitionNeuropsychologyGenderDevelopment
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 11 , Issue 5 , September 2005 , pp. 631 - 644
Copyright
© 2005 The International Neuropsychological Society

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