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Evidence for the Solidarity of the Expressive and Receptive Language Systems: A Retrospective Study

Published online by Cambridge University Press:  10 November 2010

Dana C. Moser ,
Andrew C. Papanicolaou ,
Paul Swank  and
Joshua I. Breier
Dana C. Moser
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Andrew C. Papanicolaou*
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas
Paul Swank
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas
Joshua I. Breier
Affiliation:
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas
*
Correspondence and reprint requests to: Andrew C. Papanicolaou, Center for Clinical Neurosciences, University of Texas Health Science Center at Houston, 1333 Moursund Street, Ste. H 114, Houston, TX 77030. E-mail: [email protected]
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Abstract

A strong tendency toward left hemisphere (LH) language dominance has been well established, as evidenced by the high prevalence of language impairment following sudden onset lesions in the LH. In the presence of progressive LH pathology, such as epilepsy, substantial deviations in language organization can occur. However, the question regarding whether reorganization involves both expressive and receptive language functions or only the one directly affected by the primary location of pathology has not been settled. Using Wada testing scores from 296 epilepsy patients and estimated rates of typical dominance in the normal population, we assessed the frequency with which left frontal and temporal pathology resulted in reorganization of only the expressive or receptive language function or both. The comparisons revealed: (1) a significantly higher prevalence of atypical organization (i.e., deviations from LH dominance) among the LH patients compared to normal population estimates and right hemisphere patients, and (2) that regardless of pathology location within the LH, the rates of atypical reorganization for both expressive and receptive language were essentially equal. These results constitute evidence that the two language functions are intimately yoked and that when disruption to the system results in reorganization, it usually yields functional changes throughout the system. (JINS, 2010, 17, 000–000)

Keywords

Brain plasticityEpilepsyFunctional reorganizationHandednessHemispheric dominanceWada procedure
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 1 , January 2011 , pp. 62 - 68
Copyright
Copyright © The International Neuropsychological Society 2010

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