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Elevated pulse pressure is associated with age-related decline in language ability

Published online by Cambridge University Press:  21 July 2010

D.A. NATION ,
C.E. WIERENGA ,
L. DELANO-WOOD ,
A.J. JAK ,
D.C. DELIS ,
D.P. SALMON  and
M.W. BONDI
D.A. NATION
Affiliation:
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California
C.E. WIERENGA
Affiliation:
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California VA San Diego Healthcare System, San Diego, California
L. DELANO-WOOD
Affiliation:
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California VA San Diego Healthcare System, San Diego, California
A.J. JAK
Affiliation:
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California VA San Diego Healthcare System, San Diego, California
D.C. DELIS
Affiliation:
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California VA San Diego Healthcare System, San Diego, California
D.P. SALMON
Affiliation:
Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California
M.W. BONDI*
Affiliation:
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California VA San Diego Healthcare System, San Diego, California
*
*Correspondence and reprint requests to: Mark W Bondi, 3350 La Jolla Village Dr., San Diego, CA 92161. E-mail: [email protected]
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Abstract

Recent research suggests that pulse pressure (PP), a putative marker of vascular integrity, may be associated with brain microvascular damage and age-related cognitive decline. Thus, the present study examined the relationship between PP and cognition in a sample of healthy nondemented older adults. One hundred nine participants were administered neurological and neuropsychological evaluations and determined to be nondemented. Regression analyses were used to examine the relationships among pulse pressure (PP) [systolic blood pressure (SBP) – diastolic blood pressure (DBP)], age, and cognition. PP and related measures were inversely correlated with global cognitive functioning and scores on a composite measure of language function, even after adjusting for age, education, and relevant vascular risk factors. Results indicate that increases in the pulsatile component of blood pressure may convey added risk of global cognitive decline and specific impairment in language abilities. (JINS, 2010, 16, 933–938.)

Keywords

Blood pressureHypertensionAgingCognitionStrokeArterial stiffness
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 5 , September 2010 , pp. 933 - 938
Copyright
Copyright © The International Neuropsychological Society 2010

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