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Disinhibition in Frontotemporal Dementia and Alzheimer’s Disease: A Neuropsychological and Behavioural Investigation

Published online by Cambridge University Press:  23 September 2019

Luciano I. Mariano Open the ORCID record for Luciano I. Mariano [Opens in a new window] ,
Claire O’Callaghan ,
Henrique C. Guimarães ,
Leandro B. Gambogi ,
Thaís B.L. da Silva ,
Mônica S. Yassuda Open the ORCID record for Mônica S. Yassuda [Opens in a new window] ,
Juliana S. Amaral ,
Paulo Caramelli ,
Michael Hornberger  and
Antônio L. Teixeira
...Show all authors
Luciano I. Mariano
Affiliation:
Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil
Claire O’Callaghan
Affiliation:
Brain and Mind Research Institute, University of Sydney, Sydney 2050, Australia Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK
Henrique C. Guimarães
Affiliation:
Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil
Leandro B. Gambogi
Affiliation:
Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil
Thaís B.L. da Silva
Affiliation:
Cognitive Behavior Neurology Group (GNCC), Neurology Department, University of São Paulo, São Paulo 05403-000, Brazil Gerontology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil
Mônica S. Yassuda
Affiliation:
Cognitive Behavior Neurology Group (GNCC), Neurology Department, University of São Paulo, São Paulo 05403-000, Brazil Gerontology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil
Juliana S. Amaral
Affiliation:
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil
Paulo Caramelli
Affiliation:
Departamento de Clínica Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil
Michael Hornberger
Affiliation:
Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
Antônio L. Teixeira
Affiliation:
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, UTHealth Houston, Houston, TX 77030, USA
Leonardo C. de Souza*
Affiliation:
Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil Departamento de Clínica Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil
*
Correspondence and reprint requests to: Leonardo Cruz de Souza, Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, no. 190/sl 281, Santa Efigênia, Belo Horizonte, MG 30130-100, Brazil. E-mail: [email protected]
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Abstract

Objective:

Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer’s disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD.

Methods:

Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11).

Results:

bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001).

Conclusions:

Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.

Keywords

Behavioural variant Frontotemporal DementiaAlzheimer’s diseaseImpulsivityInhibitory controlDelay discountingExecutive function
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 2 , February 2020 , pp. 163 - 171
Copyright
Copyright © INS. Published by Cambridge University Press, 2019 

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