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Coordinated and circumlocutory semantic naming errors are related to anterolateral temporal lobes in mild AD, amnestic mild cognitive impairment, and normal aging

Published online by Cambridge University Press:  04 October 2010

MARCIO LUIZ FIGUEREDO BALTHAZAR ,
CLARISSA LIN YASUDA ,
FABRÍCIO RAMOS SILVESTRE PEREIRA ,
FELIPE PAULO GUAZZI BERGO ,
FERNANDO CENDES  and
BENITO PEREIRA DAMASCENO
MARCIO LUIZ FIGUEREDO BALTHAZAR*
Affiliation:
Neuropsychology and Neurolinguistics Unit, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil Neuroimaging Laboratory, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil
CLARISSA LIN YASUDA
Affiliation:
Neuroimaging Laboratory, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil
FABRÍCIO RAMOS SILVESTRE PEREIRA
Affiliation:
Neuroimaging Laboratory, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil
FELIPE PAULO GUAZZI BERGO
Affiliation:
Neuroimaging Laboratory, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil
FERNANDO CENDES
Affiliation:
Neuroimaging Laboratory, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil
BENITO PEREIRA DAMASCENO
Affiliation:
Neuropsychology and Neurolinguistics Unit, Department of Neurology, Medical School, University of Campinas (UNICAMP), Brazil
*
*Correspondence and reprint requests to: Marcio L.F. Balthazar, Department of Neurology, Medical School, University of Campinas (UNICAMP), Postcode: 13083-970, Campinas-SP, Brazil. Email: [email protected]
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Abstract

Naming difficulties are characteristic of Alzheimer’s disease (AD) and, to a lesser extent, of amnestic mild cognitive impairment (aMCI) patients. The association of naming impairment with anterior temporal lobe (ATL) atrophy in Semantic Dementia (SD) could be a tip of the iceberg effect, in which case the atrophy is a marker of more generalized temporal lobe pathology. Alternatively, it could reflect the existence of a functional gradient within the temporal lobes, wherein more anterior regions provide the basis for greater specificity of representation. We tested these two hypotheses in a study of 15 subjects with mild AD, 17 with aMCI, and 16 aged control subjects and showed that coordinate and circumlocutory semantic error production on the Boston Naming Test was weakly correlated with ATL gray matter density, as determined by voxel-based morphometry. Additionally, we investigated whether these errors were benefited by phonemic cues, and similarly to SD, our AD patients had small improvement. Because there is minimal gradient of temporal lobe atrophy in AD or MCI, and, therefore, no basis for a tip of the iceberg effect, these findings support the theory of a modest functional gradient in the temporal lobes, with the ATLs being involved in the naming of more specific objects. (JINS, 2010, 16, 1099–1107.)

Keywords

Semantic memoryTemporal lobeNamingCueingVoxel-based morphometryMild cognitive impairment
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 6 , November 2010 , pp. 1099 - 1107
Copyright
Copyright © The International Neuropsychological Society 2010

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