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Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C

Published online by Cambridge University Press:  18 May 2007

LINAS A. BIELIAUSKAS ,
CARLA BACK-MADRUGA ,
KAREN L. LINDSAY ,
ELIZABETH C. WRIGHT ,
ZIAD KRONFOL ,
ANNA S.F. LOK  and
ROBERT J. FONTANA
LINAS A. BIELIAUSKAS
Affiliation:
Neuropsychology Section, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan Psychology Service, Veterans Affairs Healthcare System, Ann Arbor, Michigan
CARLA BACK-MADRUGA
Affiliation:
Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, California
KAREN L. LINDSAY
Affiliation:
Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California
ELIZABETH C. WRIGHT
Affiliation:
New England Research Institutes, Watertown, Massachusetts Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
ZIAD KRONFOL
Affiliation:
Neuropsychology Section, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan
ANNA S.F. LOK
Affiliation:
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan
ROBERT J. FONTANA
Affiliation:
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan
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Abstract

This study evaluated the influence of cognitive reserve on neuropsychological test performance in 198 patients infected with the hepatitis C virus. IQ scores, educational level, and occupational rating were combined to calculate a Cognitive Reserve Score (CRS) for each patient. Similar to studies of infection with the human immunodeficiency virus, there was a significantly increased risk of impairment in neuropsychological test performance in individuals with lower CRSs. It is important to account for CRS when assessing cognitive findings in large-scale clinical trials. (JINS, 2007, 13, 687–692.)Financial relationships of the authors with Hoffmann-La Roche, Inc., are as follows: K.L. Lindsay is a consultant and receives research support; A.S.F. Lok is a consultant and receives grant support; and R.J. Fontana is on the speaker's bureau. Authors with no financial relationships related to this project are as follows: L.A. Bieliauskas, C. Back-Madruga, E.C. Wright, and Z. Kronfol.

Keywords

Liver diseasesHepatic insufficiencyIntelligenceIQCognitive manifestationsNeurobehavioral manifestations
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 4 , July 2007 , pp. 687 - 692
Copyright
© 2007 The International Neuropsychological Society

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