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The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure

Published online by Cambridge University Press:  17 July 2014

Tanya T. Nguyen ,
Leila Glass ,
Claire D. Coles ,
Julie A. Kable ,
Philip A. May ,
Wendy O. Kalberg ,
Elizabeth R. Sowell ,
Kenneth L. Jones ,
Edward P. Riley  and
Sarah N. Mattson
...Show all authors
Tanya T. Nguyen
Affiliation:
Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, California
Leila Glass
Affiliation:
Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, California
Claire D. Coles
Affiliation:
Department of Psychiatry and Behavior Sciences, Emory University School of Medicine, Atlanta, Georgia Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Julie A. Kable
Affiliation:
Department of Psychiatry and Behavior Sciences, Emory University School of Medicine, Atlanta, Georgia
Philip A. May
Affiliation:
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina Nutrition Research Institute, Kannapolis, North Carolina Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico
Wendy O. Kalberg
Affiliation:
Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico
Elizabeth R. Sowell
Affiliation:
Developmental Cognitive Neuroimaging Laboratory, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California Division of Research on Children, Youth, and Families, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, California
Kenneth L. Jones
Affiliation:
Department of Pediatrics, School of Medicine, University of California, San Diego, California.
Edward P. Riley
Affiliation:
Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, California
Sarah N. Mattson*
Affiliation:
Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, California
*
Correspondence and reprint requests to: Sarah N. Mattson, 6330 Alvarado Court, Suite 100, San Diego, CA 92120. E-mail: [email protected]
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Abstract

Prenatal alcohol exposure and attention-deficit/hyperactivity disorder (ADHD) result in behavioral issues related to poor executive function (EF). This overlap may hinder clinical identification of alcohol-exposed children. This study examined the relation between parent and neuropsychological measures of EF and whether parent ratings aid in differential diagnosis. Neuropsychological measures of EF, including the Delis-Kaplan Executive Function System (D-KEFS), were administered to four groups of children (8–16 years): alcohol-exposed with ADHD (AE+, n=80), alcohol-exposed without ADHD (AE−, n=36), non-exposed with ADHD (ADHD, n=93), and controls (CON, n=167). Primary caregivers completed the Behavior Rating Inventory of Executive Function (BRIEF). For parent ratings, multivariate analyses of variance revealed main effects of Exposure and ADHD and an interaction between these factors, with significant differences between all groups on nearly all BRIEF scales. For neuropsychological measures, results indicated main effects of Exposure and ADHD, but no interaction. Discriminant function analysis indicated the BRIEF accurately classifies groups. These findings confirm compounded behavioral, but not neuropsychological, effects in the AE+ group over the other clinical groups. Parent-report was not correlated with neuropsychological performance in the clinical groups and may provide unique information about neurobehavior. Parent-report measures are clinically useful in predicting alcohol exposure regardless of ADHD. Results contribute to a neurobehavioral profile of prenatal alcohol exposure. (JINS, 2014, 20, 1–13)

Keywords

Fetal alcohol spectrum disorders (FASD)Fetal alcohol syndrome (FAS)Behavior Rating Inventory of Executive Function (BRIEF)Pediatric neuropsychologyParent-reportAttention-deficit/hyperactivity disorder (ADHD)
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Supplement 7 , August 2014 , pp. 704 - 716
Copyright
Copyright © The International Neuropsychological Society 2014 

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References

REFERENCES

Achenbach, T.M., McConaughy, S.H., & Howell, C.T. (1987). Child/adolescent behavioral and emotional problems: Implications of cross-informant correlations for situational specificity. Psychological Bulletin, 101(2), 213–232. doi:10.1037/0033-2909.101.2.213 Google Scholar
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, DSM-IV-TR. Washington, DC: American Psychiatric Publishing, Inc.Google Scholar
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, DSM-5 (5th ed.). Arlington, VA: American Psychiatric Publishing, Inc.Google Scholar
Anderson, V.A., Anderson, P., Northam, E., Jacobs, R., & Mikiewicz, O. (2002). Relationships between cognitive and behavioral measures of executive function in children with brain disease. Child Neuropsychology, 8(4), 231–240. doi:10.1076/chin.8.4.231.13509 Google Scholar
Bastiaansen, D., Koot, H.M., & Ferdinand, R.F. (2005). Determinants of quality of life in children with psychiatric disorders. Quality of Life Research, 14(6), 1599–1612. doi:10.1007/s11136-004-7711-2 Google Scholar
Bechara, A., Damasio, H., & Damasio, A.R. (2000). Emotion, decision making and the orbitofrontal cortex. Cerebral Cortex, 10(3), 295–307. doi:10.1093/cercor/10.3.295 CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, H., Tranel, D., & Anderson, S.W. (1998). Dissociation of working memory from decision making within the human prefrontal cortex. 18(1), 428–437.Google Scholar
Bodnar, L.E., Prahme, M.C., Cutting, L.E., Denckla, M.B., & Mahone, E.M. (2007). Construct validity of parent ratings of inhibitory control. Child Neuropsychology, 13(4), 345–362. doi:10.1080/09297040600899867 Google Scholar
Bradley, R.H., & Corwyn, R.F. (2002). Socioeconomic status and child development. Annual Review of Psychology, 53, 371–399. doi:10.1146/annurev.psych.53.100901.135233 Google Scholar
Cummings, J.L. (1993). Frontal-subcortical circuits and human behavior. Archives of Neurology, 50(8), 873–880. doi:10.1001/archneur.1993.00540080076020 Google Scholar
Delis, D.C., Kaplan, E., & Kramer, J.H. (2001). The Delis-Kaplan executive function system: Examiner’s manual. San Antonio, TX: The Psychological Corporation.Google Scholar
Dennis, M., Francis, D.J., Cirino, P.T., Schachar, R., Barnes, M.A., & Fletcher, J.M. (2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society, 15(3), 331–343. doi:10.1017/S1355617709090481 Google Scholar
Doig, J., McLennan, J.D., & Gibbard, W.B. (2008). Medication effects on symptoms of attention-deficit/hyperactivity disorder in children with fetal alcohol spectrum disorder. Journal of Child and Adolescent Psychopharmacology, 18(4), 365–371. doi:10.1089/cap.2007.0121 CrossRefGoogle ScholarPubMed
Duarte Silva, A.P., & Stam, A. (1995). Discriminant analysis. In L.G. Grimm & P.R. Yarnold (Eds.), Reading and understanding multivariate statistics (pp. 277–318). Washington, DC: American Psychological Association.Google Scholar
Faraone, S.V., Monuteaux, M.C., Biederman, J., Cohan, S.L., & Mick, E. (2003). Does parental ADHD bias maternal reports of ADHD symptoms in children? Journal of Consulting and Clinical Psychology, 71(1), 168–175. doi:10.1037/0022-006X.71.1.168 Google Scholar
Fryer, S.L., McGee, C.L., Matt, G.E., Riley, E.P., & Mattson, S.N. (2007). Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure. Pediatrics, 119(3), e733–e741. doi:10.1542/peds.2006-1606 Google Scholar
Fuster, J.M. (2000). Executive frontal functions. Experimental Brain Research, 133(1), 66–70.Google Scholar
Gioia, G.A., Isquith, P.K., Guy, S.C., & Kenworthy, L. (2000a). Behavior rating inventory of executive function. Child Neuropsychology, 6(3), 235–238. doi:10.1076/chin.6.3.235.3152 Google Scholar
Gioia, G.A., Isquith, P.K., Guy, S.C., & Kenworthy, L. (2000b). Behavior rating inventory of executive function: Professional manual. Odessa, FL: Psychological Assessment Resources, Inc.Google Scholar
Glass, L., Graham, D.M., Deweese, B.N., Jones, K.L., Riley, E.P., & Mattson, S.N. (2013). Correspondence of parent report and laboratory measures of inattention and hyperactivity in children with heavy prenatal alcohol exposure. Neurotoxicology and Teratology, 42, 43–50. doi:10.1016/j.ntt.2014.01.007 Google Scholar
Glass, L., Ware, A.L., Crocker, N., Deweese, B.N., Coles, C.D., Kable, J.A., ... and the CIFASD (2013). Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD. Neuropsychology, 27(6), 713–724. doi:10.1037/a0033994 Google Scholar
Graham, D.M., Crocker, N., Deweese, B.N., Roesch, S.C., Coles, C.D., Kable, J.A., … and the CIFASD. (2013). Prenatal alcohol exposure, attention-deficit/hyperactivity disorder, and sluggish cognitive tempo. Alcoholism: Clinical and Experimental Research, 37(Suppl. 1), E338–E346. doi:10.1111/j.1530-0277.2012.01886.x Google Scholar
Graham, D.M., Deweese, B.N., Roesch, S.C., Coles, C.D., Kable, J.A., May, P.A., … and the CIFASD. (2013). Discriminating behavioral subtypes among children with heavy prenatal alcohol exposure. (Manuscript under review).Google Scholar
Howarth, R.A., Ashford, J.M., Merchant, T.E., Ogg, R.J., Santana, V., Wu, S., Conklin, H.M. (2013). The utility of parent report in the assessment of working memory among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 19(4), 380–389. doi:10.1017/S1355617712001567 Google Scholar
Hoyme, H.E., May, P.A., Kalberg, W.O., Kodituwakku, P., Gossage, J.P., Trujillo, P.M., Robinson, L.K. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115(1), 39–47. doi:10.1542/peds.2004-0259 Google Scholar
IBM Corporation. (2011). IBM SPSS Statistics 20.0.Google Scholar
Jones, K.L., Robinson, L.K., Bakhireva, L.N., Marintcheva, G., Storojev, V., Strahova, A., Chambers, C.D. (2006). Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training. Pediatrics, 118(6), e1734–e1738. doi:10.1542/peds.2006-1037 Google Scholar
Kodituwakku, P.W. (2007). Defining the behavioral phenotype in children with fetal alcohol spectrum disorders: A review. Neuroscience and Biobehavioral Reviews, 31(2), 192–201. doi:10.1016/j.neubiorev.2006.06.020 Google Scholar
Mahone, E.M., Cirino, P.T., Cutting, L.E., Cerrone, P.M., Hagelthorn, K.M., Hiemenz, J.R., Denckla, M.B. (2002). Validity of the behavior rating inventory of executive function in children with ADHD and/or Tourette syndrome. Archives of Clinical Neuropsychology, 17(7), 643–662. doi:10.1016/S0887-6177(01)00168-8 Google Scholar
Marcotte, T.D., Scott, J.C., Kamat, R., & Heaton, R.K. (2010). Neuropsychology and the prediction of everyday functioning. In T.D. Marcotte & I. Grant (Eds.), Neuropsychology of everyday functioning (pp. 5–38). New York: The Guilford Press.Google Scholar
Mattson, S.N., Crocker, N., & Nguyen, T.T. (2011). Fetal alcohol spectrum disorders: Neuropsychological and behavioral features. Neuropsychology Review, 21(2), 81–101. doi:10.1007/s11065-011-9167-9 Google Scholar
Mattson, S.N., Foroud, T., Sowell, E.R., Jones, K.L., Coles, C.D., & Fagerlund, Å., … and the CIFASD. (2010). Collaborative initiative on fetal alcohol spectrum disorders: Methodology of clinical projects. Alcohol 44(7–8), 635–641. doi:10.1016/j.alcohol.2009.08.005 Google Scholar
Mattson, S.N., & Riley, E.P. (2011). The quest for a neurobehavioral profile of heavy prenatal alcohol exposure. Alcohol Research and Health, 34(1), 51–55.Google Scholar
Mattson, S.N., Riley, E.P., Gramling, L., Delis, D.C., & Jones, K.L. (1997). Heavy prenatal alcohol exposure with or without physical features of fetal alcohol syndrome leads to IQ deficits. Journal of Pediatrics, 131(5), 718–721. doi:10.1016/S0022–3476(97)70099-4 CrossRefGoogle ScholarPubMed
Mattson, S.N., Roesch, S.C., Fagerlund, Å., Autti–Rämö, I., Jones, K.L., May, P.A., … and the CIFASD (2010). Toward a neurobehavioral profile of fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 34(9), 1640–1650. doi:10.1111/j.1530-0277.2010.01250.x Google Scholar
Mattson, S.N., Roesch, S.C., Glass, L., Deweese, B.N., Coles, C.D., & Kable, J.A., … and the CIFASD. (2013). Further development of a neurobehavioral profile of fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 37(3), 517–528. doi:10.1111/j.1530-0277.2012.01952.x Google Scholar
May, P.A., Gossage, J.P., Kalberg, W.O., Robinson, L.K., Buckley, D., Manning, M., & Hoyme, H.E. (2009). Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Developmental Disabilities Research Reviews, 15(3), 176–192. doi:10.1002/ddrr.68 Google Scholar
McCandless, S., & O’Laughlin, L. (2007). The clinical utility of the Behavior Rating Inventory of Executive Function (BRIEF) in the diagnosis of ADHD. Journal of Attention Disorders, 10(4), 381–389. doi:10.1177/1087054706292115 Google Scholar
McGee, C.L., Fryer, S.L., Bjorkquist, O.A., Mattson, S.N., & Riley, E.P. (2008). Deficits in social problem solving in adolescents with prenatal exposure to alcohol. The American Journal of Drug and Alcohol Abuse, 34(4), 423–431. doi:10.1080/00952990802122630 CrossRefGoogle ScholarPubMed
Merikangas, K.R., He, J.P., Brody, D., Fisher, P.W., Bourdon, K., & Koretz, D.S. (2010). Prevalence and treatment of mental disorders among US children in the 2001-2004 NHANES. Pediatrics, 125(1), 75–81. doi:10.1542/peds.2008-2598 Google Scholar
Myers, A.M., Holliday, P.J., Harvey, K.A., & Hutchinson, K.S. (1993). Functional performance measures: Are they superior to self-assessments? Journal of Gerontology, 48(5), M196–M206. doi:10.1093/geronj/48.5.M196 Google Scholar
Newton, R.R., Litrownik, A.J., & Landsverk, J.A. (2000). Children and youth in foster care: Disentangling the relationship between problem behaviors and number of placements. Child Abuse and Neglect, 24(10), 1363–1374. doi:10.1016/S0145-2134(00)00189-7 Google Scholar
Oesterheld, J.R., Kofoed, L., Tervo, R., Fogas, B., Wilson, A., & Fiechtner, H. (1998). Effectiveness of methylphenidate in Native American children with fetal alcohol syndrome and attention deficit/hyperactivity disorder: A controlled pilot study. Journal of Child and Adolescent Psychopharmacology, 8(1), 39–48. doi:10.1089/cap.1998.8.39 Google Scholar
Parrish, J., Geary, E., Jones, J., Seth, R., Hermann, B., & Seidenberg, M. (2007). Executive functioning in childhood epilepsy: Parent-report and cognitive assessment. Developmental Medicine and Child Neurology, 49(6), 412–416. doi:10.1111/j.1469-8749.2007.00412.x Google Scholar
Peadon, E., & Elliott, E.J. (2010). Distinguishing between attention-deficit hyperactivity and fetal alcohol spectrum disorders in children: Clinical guidelines. Neuropsychiatric Disease and Treatment, 6, 509–515.Google Scholar
Pressman, L.J., Loo, S.K., Carpenter, E.M., Asarnow, J.R., Lynn, D., McCracken, J.T., Smalley, S.L. (2006). Relationship of family environment and parental psychiatric diagnosis to impairment in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 45(3), 346–354. doi:10.1097/01.chi.0000192248.61271.c8 Google Scholar
Rader, N., & Hughes, E. (2005). The influence of affective state on the performance of a block design task in 6–and 7-year-old children. Cognition & Emotion, 19(1), 143–150. doi:10.1080/02699930441000049 Google Scholar
Rasmussen, C., Benz, J., Pei, J., Andrew, G., Schuller, G., Abele-Webster, L., Lord, L. (2010). The impact of an ADHD co-morbidity on the diagnosis of FASD. The Canadian Journal of Clinical Pharmacology, 17(1), e165–e176.Google ScholarPubMed
Rasmussen, C., McAuley, R., & Andrew, G. (2007). Parental ratings of children with fetal alcohol spectrum disorder on the Behavior Rating Inventory of Executive Functioning (BRIEF). Journal of FAS International, 5, 1–8.Google Scholar
Shaffer, D., Fisher, P., Lucas, C.P., Dulcan, M.K., & Schwab-Stone, M.E. (2000). NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, differences from previous versions, and reliability of some common diagnoses. Journal of the American Academy of Child and Adolescent Psychiatry, 39(1), 28–38. doi:10.1097/00004583-200001000-00014 Google Scholar
Snyder, J., Nanson, J., Snyder, R., & Block, G. (1997). A study of stimulant medication in children with FAS. In A.P. Streissguth & J. Kanter (Eds.), In the challenge of fetal alcohol syndrome: Overcoming secondary disabilities (pp. 64–77). Seattle, WA: University of Washington Press.Google Scholar
Streissguth, A.P., Barr, H.M., Kogan, J., & Bookstein, F.L. (1996). Final report: Understanding the occurrence of secondary disabilities in clients with fetal alcohol syndrome (FAS) and fetal alcohol effects (FAE). Seattle, WA: University of Washington Publication Services.Google Scholar
Streissguth, A.P., Bookstein, F.L., Barr, H.M., Sampson, P.D., O’Malley, K., & Young, J.K. (2004). Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. Journal of Developmental and Behavioral Pediatrics, 25(4), 228–238.Google Scholar
Toplak, M.E., Bucciarelli, S.M., Jain, U., & Tannock, R. (2009). Executive functions: Performance-based measures and the behavior rating inventory of executive function (BRIEF) in adolescents with attention deficit/hyperactivity disorder (ADHD). Child Neuropsychology, 15(1), 53–72. doi:10.1080/09297040802070929 Google Scholar
Vriezen, E.R., & Pigott, S.E. (2002). The relationship between parental report on the BRIEF and performance-based measures of executive function in children with moderate to severe traumatic brain injury. Child Neuropsychology, 8(4), 296–303. doi:10.1076/chin.8.4.296.13505 Google Scholar
Wadley, V.G., Harrell, L.E., & Marson, D.C. (2003). Self- and informant report of financial abilities in patients with Alzheimer's disease: Reliable and valid? Journal of the American Geriatrics Society, 51(11), 1621–1626. doi:10.1046/j.1532-5415.2003.51514.x Google Scholar
Ware, A.L., O’Brien, J.W., Crocker, N., Deweese, B.N., Roesch, S.C., Coles, C.D., … and the CIFASD. (2013). The effects of prenatal alcohol exposure and attention-deficit/hyperactivity disorder on psychopathology and behavior. Alcoholism: Clinical and Experimental Research, 37(3), 507–516. doi:10.1111/j.1530-0277.2012.01953.x Google Scholar
Wechsler, D. (2003). Manual for the Wechsler Intelligence Scale for Children-Fourth Edition (4th ed.). San Antonio: Pearson.Google Scholar
Werner, E.E. (1986). Resilient offspring of alcoholics: A longitudinal study from birth to age 18. Journal of Studies on Alcohol, 47(1), 34–40.Google Scholar
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