Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-25T07:18:51.003Z Has data issue: false hasContentIssue false
  • English
  • Français

An investigation of decision making in anorexia nervosa using the Iowa Gambling Task and skin conductance measurements

Published online by Cambridge University Press:  18 May 2007

KATE TCHANTURIA ,
PEI-CHI LIAO ,
RUDOLF UHER ,
NATALIA LAWRENCE ,
JANET TREASURE  and
IAIN C. CAMPBELL
KATE TCHANTURIA
Affiliation:
Institute of Psychiatry, Kings College, London, United Kingdom
PEI-CHI LIAO
Affiliation:
Institute of Psychiatry, Kings College, London, United Kingdom
RUDOLF UHER
Affiliation:
Institute of Psychiatry, Kings College, London, United Kingdom
NATALIA LAWRENCE
Affiliation:
Institute of Psychiatry, Kings College, London, United Kingdom
JANET TREASURE
Affiliation:
Institute of Psychiatry, Kings College, London, United Kingdom
IAIN C. CAMPBELL
Affiliation:
Institute of Psychiatry, Kings College, London, United Kingdom
Get access Rights & Permissions [Opens in a new window]

Abstract

The objective of this study is to determine (a) if decision making ability is impaired in patients with anorexia nervosa (AN) and in people with good recovery from AN and (b) whether any impairment in decision making is associated with alterations in skin conductance responses (SCR). Patients with AN (n = 29), healthy controls comparable in age and IQ (HC, n = 29), and women long term recovered from AN (n = 14), completed the Iowa Gambling Task (IGT) while their SCR were measured. AN patients performed poorly in the IGT compared to the HC and to the recovered AN participants. AN patients had decreased anticipatory SCR prior to choosing cards and reduced SCR after losses compared to HC. IGT performance and the SCR of recovered AN participants did not differ from the HC. Decision making ability is impaired in AN. It is associated with a significantly attenuated SCR. Neither of these features are found in recovered AN. The association between impaired decision making ability and a decreased autonomic response is consistent with the predictions of the Somatic Marker Hypothesis. (JINS, 2007, 13, 635–641.)

Keywords

Eating disordersRecoveryNeuropsychologyBiological markersIowa Gambling TaskGalvanic skin response
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 4 , July 2007 , pp. 635 - 641
Copyright
© 2007 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bechara, A., Damasio, H., Damasio, A.R., & Lee, G.P. (1999). Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. The Journal of Neuroscience, 19, 5473–5481.Google Scholar
Bechara, A., Damasio, H., Tranel, D., & Damasio, A.R. (1997). Deciding advantageously before knowing the advantageous strategy. Science, 275, 1293–1295.Google Scholar
Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 53, 561–571.Google Scholar
Bergen, A.W., Yeager, M., Welch, R.A., Haque, K., Ganjei, J.K., van den Bree, M.B., Mazzanti, C., Nardi, I., Fichter, M., Halmi, K., Kaplan, A., Strober, M., Treasure, J., Woodside, B., Bulik, C., Bacanu, S., Devlin, B., Berrettini, W., Goldman, D., & Kaye, W. (2005). Association of Multiple DRD2 Polymorphisms with anorexia nervosa. Neuropsychopharmacology, 30, 1703–1710.Google Scholar
Blinder, B., Cumella, E.J., & Sanathara, V.A. (2006). Psychiatric comorbidities of female inpatients with eating disorders. Psychosoatic Medicine, 68, 454–462.Google Scholar
Cavedini, P., Bassi, T., Ubbiali, A., Casolari, A., Giordani, S., Zorzi, C., & Bellodi, L. (2004). Neuropsychological investigation of decision-making in anorexia nervosa. Psychiatry Research, 127, 259–266.Google Scholar
Cavedini, P., Riboldi, G., D'Annucci, A., Belotti, P., Cisima, M., & Bellodi, L. (2002). Decision-making heterogeneity in obsessive-compulsive disorder: Ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia, 40, 205–211.Google Scholar
Dalgleish, T., Yiend, J., Bramham, J., Teasdale, J.D., Ogilvie, A.D., Malhi, G., & Howard, R. (2004). Neuropsychological processing associated with recovery from depression after stereotactic subcaudate tractotomy. American Journal of Psychiatry, 161, 1913–1916.Google Scholar
Damasio, A. (2004). Looking for Spinoza. London: Vintage.
Davidson, R.J., Pizzagali, D., Nitschke, J.B., & Putnam, K. (2002). Depression: Perspectives from affective neuroscience. Annual Review of Psychology, 53, 545–574Google Scholar
Fairburn, C.G. & Beglin, S.J. (1994). Assessment of eating disorders: Interview or self-report questionnaire? International Journal of Eating Disorders, 16, 363–370.Google Scholar
Fein, G., Klein, L., & Finn, P. (2004). Impairment on a simulated gambling task in long-term abstinent alcoholics. Alcoholism Clinical and Experimental Research, 28, 1487–1491.Google Scholar
Garon, N., Moore, C., & Waschbusch, D.A. (2006). Decision making in children with ADHD only, ADHD-anxious/depressed, and control children using a child version of the Iowa Gambling Task. Journal of Attention Disorders, 9, 607–619.Google Scholar
Green, M.W., Elliman, N.A., Wakeling, A., & Rogers, P.J. (1996). Cognitive functioning, weight change and therapy in anorexia nervosa. Journal of Psychiatric Research, 30, 401–410.Google Scholar
Halmi, K.A. & Sunday, S.R. (1991). Temporal patterns of hunger and fullness ratings and related cognitions in anorexia and bulimia. Appetite, 16, 219–237.Google Scholar
Hornak, J., O'Doherty, J., Bramham, J., Rolls, E.T., Morris, R.G., Bullock, P.R., & Polkey, C. (2004). Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. Journal of Cognitive Neuroscience, 16, 463–478.Google Scholar
Jollant, F., Bellivier, F., Leboyer, M., Astruc, B., Torres, S., Verdier, R., Castelnau, D., Malafosse, A., & Courtet, P. (2005). Impaired decision making in suicide attempters. American Journal of Psychiatry, 162, 304–310.Google Scholar
Kaye, W.H., Ebert, M.H., Raleigh, M., & Lake, R. (1984). Abnormalities in CNS monoamine metabolism in anorexia nervosa. Archives of General Psychiatry, 41, 350–355.Google Scholar
Kaye, W.H., Klump, K.L., Frank, G.K., & Strober, M. (2000). Anorexia and bulimia nervosa. Annual Review of Medicine, 51, 299–313.Google Scholar
Lattimore, P., Gowers, S., & Wagner, H. (2000). Autonomic arousal and conflict avoidance in anorexia nervosa: A pilot study. European Eating Disorders Review, 8, 31–39.Google Scholar
Lawrence, N., Wooderson, S., Mataix-Cols, D., David, R., Speckens, A., & Phillips, M. (2006). Decision-making and set-shifting impairments are associated with distinct symptom dimensions in OCD. Neuropsychology, 20, 409–419.Google Scholar
Maia, T.V. & McClelland, J.L. (2004). A reexamination of the evidence for the somatic marker hypothesis: What participants really know in the Iowa Gambling Task. Proceedings of the National Academy of Sciences of the United States of America PNAS, 101, 16075–16080.Google Scholar
Nelson, H.E. & Willison, J.W. (1992). National Adult Reading Test (NART). (2nd ed.) Windsor.
Papezova, H., Yamamotova, A., & Uher, R. (2005). Elevated pain threshold in eating disorders: Physiological and psychological factors. Journal of Psychiatric Research, 39, 431–438.Google Scholar
Roberts, M., Tchanturia, K., Stahl, D., Southgate, L., & Treasure J. (2007). A systematic review and meta-analysis of set-shifting ability in eating disorders. Psychological Medicine (in press, online).Google Scholar
Rolls, E.T. (1996). The orbitofrontal cortex. Philosophical Transactions of the Royal Society: Biological Sciences, 351, 1433–1443.Google Scholar
Rottenberg, J., Gross, J.J., & Gotlib, I.H. (2005). Emotion context insensitivity in major depressive disorder. Journal of Abnormal Psychology, 114, 627–639.Google Scholar
Scarna, A., McTavish, S.F., Cowen, P.J., Goodwin, G.M., & Rogers, R.D. (2005). The effects of a branched chain amino acid mixture supplemented with tryptophan on biochemical indices of neurotransmitter function and decision-making. Psychopharmacology, 179, 761–768.Google Scholar
Southgate, L., Tchanturia, K., & Treasure, J. (2005). Neuropsychological performance in Anorexia Nervosa: A systematic review of Frontal Lobe functions. In P.I. Swain (Ed.), Eating Disorders: New Research. New York: Nova Science Publishers.
Tchanturia, K., Brecelj Anderluh, M., Morris, R., Rabe-Hesketh, S., Collier, D., Sanchez, P., & Treasure, J. (2004). Cognitive Flexibility in anorexia nervosa and bulimia nervosa. Journal of International Neuropsychological Society, 10, 513–520.Google Scholar
Tchanturia, K., Campbell, I.C., Morris, R., & Treasure, J. (2005). Neuropsychological studies in anorexia nervosa. International Journal of Eating Disorders, 37, 572–576.Google Scholar
Tomb, I., Hauser, M., Deldin, P., & Caramazza, A. (2002). Do somatic markers mediate decisions on the gambling task? Nature Neuroscience, 5, 1103–1104.Google Scholar
Uher, R., Brammer, M.J., Murphy, T., Campbell, I.C., Ng, V.W., Williams, S.C., & Treasure, J. (2003). Recovery and chronicity in anorexia nervosa: Brain activity associated with differential outcomes. Biological Psychiatry, 54, 934–942.Google Scholar
Uher, R., Murphy, T., Brammer, M.J., Dalgleish, T., Phillips, M.L., Ng, V.W., Andrew, C., Williams, S., Campbell, I., & Treasure, J. (2004). Medial prefrontal cortex activity associated with symptom provocation in eating disorders. American Journal of Psychiatry, 161, 1238–1246.Google Scholar
Uher, R. & Treasure, J. (2005). Brain lesions and eating disorders. Journal of Neurology Neurosurgery and Psychiatry, 76, 852–857.Google Scholar