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Alcohol Consumption Does not Impede Recovery from Mild to Moderate Traumatic Brain Injury

Published online by Cambridge University Press:  18 August 2016

Noah D. Silverberg ,
William Panenka ,
Grant L. Iverson ,
Jeffrey R. Brubacher ,
Jason R. Shewchuk ,
Manraj K.S. Heran ,
Gary C.S. Oh ,
William G. Honer  and
Rael T. Lange
Noah D. Silverberg*
Affiliation:
Division of Physical Medicine & Rehabilitation, University of British Columbia, Vancouver, Canada Rehabilitation Research Program, GF Strong Rehab Centre, Vancouver, Canada Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts Red Sox Foundation and Massachusetts General Hospital Home Base Program, Boston, Massachusetts
William Panenka
Affiliation:
British Columbia Neuropsychiatry Program, University of British Columbia, Vancouver, Canada Department of Psychiatry, University of British Columbia, Vancouver, Canada
Grant L. Iverson
Affiliation:
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts Red Sox Foundation and Massachusetts General Hospital Home Base Program, Boston, Massachusetts Department of Psychiatry, University of British Columbia, Vancouver, Canada Spaulding Rehabilitation Hospital, Boston, Massachusetts
Jeffrey R. Brubacher
Affiliation:
Department of Emergency Medicine, University of British Columbia, Vancouver, Canada
Jason R. Shewchuk
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
Manraj K.S. Heran
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
Gary C.S. Oh
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
William G. Honer
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Rael T. Lange
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada Defense and Veterans Brain Injury Center & National Intrepid Center of Excellence, Bethesda, Maryland Walter Reed National Military Medical Center, Bethesda, Maryland
*
Correspondence and reprint requests to: Noah D. Silverberg, Rehabilitation Research Program, GF Strong Rehab Centre, 4255 Laurel Street, Vancouver, British Columbia, V5Z 2G9, Canada. E-mail: [email protected]
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Abstract

Objectives: To examine the effect of pre-injury alcohol use, acute alcohol intoxication, and post-injury alcohol use on outcome from mild to moderate traumatic brain injury (TBI). Methods: Prospective inception cohort of patients who presented to the Emergency Department with mild to moderate TBI and had a blood alcohol level (BAL) taken for clinical purposes. Those who completed the 1-year outcome assessment were eligible for this study (N=91). Outcomes of interest were the count of post-concussion symptoms (British Columbia Post-Concussion Symptom Inventory), low neuropsychological test scores (Neuropsychological Assessment Battery), and abnormal regions of interest on diffusion tensor imaging (low fractional anisotropy). The main predictors were pre-injury alcohol consumption (Cognitive Lifetime Drinking History interview), BAL, and post-injury alcohol use. Results: The alcohol use variables were moderately to strongly inter-correlated. None of the alcohol use variables (whether continuous or categorical) were related to 1-year TBI outcomes in generalized linear modeling. Participants in this cohort generally had a good clinical outcome, regardless of their pre-, peri-, and post-injury alcohol use. Conclusions: Alcohol may not significantly alter long-term outcome from mild to moderate TBI. (JINS, 2016, 22, 816–827)

Keywords

Craniocerebral traumaPostconcussion symptomsNeuropsychological testsMagnetic resonance imagingDiffusion tensor imagingAlcohol drinkingAlcohol-related disorders
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 8 , September 2016 , pp. 816 - 827
Copyright
Copyright © The International Neuropsychological Society 2016 

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References

Allen, D.N., Goldstein, G., Caponigro, J.M., & Donohue, B. (2009). The effects of alcoholism comorbidity on neurocognitive function following traumatic brain injury. Applied Neuropsychology, 16(3), 186–192. doi.org/10.1080/09084280903098687 CrossRefGoogle ScholarPubMed
Altura, B.M., & Altura, B.T. (1999). Association of alcohol in brain injury, headaches, and stroke with brain-tissue and serum levels of ionized magnesium: A review of recent findings and mechanisms of action. Alcohol, 19(2), 119–130. doi.org/10.1016/S0741-8329(99)00025-7 Google Scholar
Aoki, Y., Inokuchi, R., Gunshin, M., Yahagi, N., & Suwa, H. (2012). Diffusion tensor imaging studies of mild traumatic brain injury: A meta-analysis. Journal of Neurology, Neurosurgery, and Psychiatry, 83(9), 870–876. doi.org/10.1136/jnnp-2012-302742 CrossRefGoogle ScholarPubMed
Baratz, R., Rubovitch, V., Frenk, H., & Pick, C.G. (2010). The influence of alcohol on behavioral recovery after mTBI in mice. Journal of Neurotrauma, 27(3), 555–563. doi.org/10.1089/neu.2009.0891 Google Scholar
Barker, L.H., Bigler, E.D., Johnson, S.C., Anderson, C.V., Russo, A.A., Boineau, B., & Blatter, D.D. (1999). Polysubstance abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome in older adolescents and young adults. Journal of the International Neuropsychological Society, 5(7), 593–608. Retrieved from www.ncbi.nlm.nih.gov/pubmed/10645702.Google Scholar
Beaulieu-Bonneau, S., Giguere, M., & Ouellet, M.-C. (2014). Alcohol and drug use before and in the first year after traumatic brain injury: Association with injury severity. Archives of Physical Medicine and Rehabilitation. Retrieved from ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed12&NEWS=N&AN=71665755.Google Scholar
Bombardier, C.H., Rimmele, C.T., & Zintel, H. (2002). The magnitude and correlates of alcohol and drug use before traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 83(12), 1765–1773. doi.org/10.1053/apmr.2002.36085 CrossRefGoogle ScholarPubMed
Bombardier, C.H., Temkin, N.R., Machamer, J., & Dikmen, S.S. (2003). The natural history of drinking and alcohol-related problems after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 84(2), 185–191. doi.org/10.1053/apmr.2003.50002 Google Scholar
Bühler, M., & Mann, K. (2011). Alcohol and the human brain: A systematic review of different neuroimaging methods. Alcoholism: Clinical and Experimental Research, 35(10), 1771–1793. doi.org/10.1111/j.1530-0277.2011.01540.x CrossRefGoogle Scholar
Cassidy, J.D., Cancelliere, C., Carroll, L.J., Côté, P., Hincapié, C.A., Holm, L.W., & Borg, J. (2014). Systematic review of self-reported prognosis in adults after mild traumatic brain injury: Results of the international collaboration on mild traumatic brain injury prognosis. Archives of Physical Medicine and Rehabilitation, 95(3S), S132–S151. doi.org/10.1016/j.apmr.2013.08.299 Google Scholar
Cherpitel, C.J., Ye, Y., Bond, J., Borges, G., Chou, P., Nilsen, P., & Xiang, X. (2012). Multi-level analysis of alcohol-related injury and drinking pattern: Emergency department data from 19 countries. Addiction, 107(7), 1263–1272. doi.org/10.1111/j.1360-0443.2012.03793.x CrossRefGoogle Scholar
Corrigan, J.D. (1995). Substance abuse as a mediating factor in outcome from traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 76(4), 302–309. Retrieved from www.ncbi.nlm.nih.gov/pubmed/7717829 CrossRefGoogle ScholarPubMed
Corrigan, J.D., Harrison-Felix, C., Bogner, J., Dijkers, M., Terrill, M.S., & Whiteneck, G. (2003). Systematic bias in traumatic brain injury outcome studies because of loss to follow-up. Archives of Physical Medicine and Rehabilitation, 84(2), 153–160. doi.org/10.1053/apmr.2003.50093 Google Scholar
Corrigan, J.D., Rust, E., & Lamb-Hart, G.L. (1995). The nature and extent of substance abuse problems in persons with traumatic brain injury. Journal of Head Trauma Rehabilitation, 10(3), 29–46. Retrieved from www.scopus.com/inward/record.url?eid=2-s2.0-0028810357&partnerID=tZOtx3y1 Google Scholar
Cunningham, R.M., Maio, R.F., Hill, E.M., & Zink, B.J. (2002). The effects of alcohol on head injury in the motor vehicle crash victim. Alcohol and Alcoholism, 37(3), 236–240. Retrieved from www.ncbi.nlm.nih.gov/pubmed/12003910 Google Scholar
De Guise, E., Leblanc, J., Dagher, J., Lamoureux, J., Jishi, A.A., Maleki, M., & Feyz, M. (2009). Early outcome in patients with traumatic brain injury, pre-injury alcohol abuse and intoxication at time of injury. Brain Injury, 23(11), 853–865. doi.org/10.1080/02699050903283221 Google Scholar
Dikmen, S.S., Donovan, D.M., Lberg, T., Machamer, J.E., & Temjkin, N.R. (1993). Alcohol use and its effects on neuropsychological outcome in head injury. Neuropsychology, 7(3), 296–305. doi.org/10.1037/0894-4105.7.3.296 CrossRefGoogle Scholar
Dikmen, S.S., Machamer, J.E., Donovan, D.M., Winn, H.R., & Temkin, N.R. (1995). Alcohol use before and after traumatic head injury. Annals of Emergency Medicine, 26(2), 167–176. Retrieved from www.ncbi.nlm.nih.gov/pubmed/7618779 Google Scholar
Donders, J., & Levitt, T. (2012). Criterion validity of the neuropsychological assessment battery after traumatic brain injury. Archives of Clinical Neuropsychology, 27(4), 440–445. doi.org/10.1093/arclin/acs043 Google Scholar
Eierud, C., Craddock, R.C., Fletcher, S., Aulakh, M., King-Casas, B., Kuehl, D., & Laconte, S.M. (2014). Neuroimaging after mild traumatic brain injury: Review and meta-analysis. NeuroImage: Clinical, 4, 283–294. doi.org/10.1016/j.nicl.2013.12.009 CrossRefGoogle ScholarPubMed
Grant, I. (1987). Alcohol and the brain: Neuropsychological correlates. Journal of Consulting and Clinical Psychology, 55(3), 310–324. doi.org/10.1037//0022-006X.55.3.310 Google Scholar
Hayes, D.M., Deeny, M.A., Shaner, C.A., & Nixon, K. (2013). Determining the threshold for alcohol-induced brain damage: New evidence with gliosis markers. Alcoholism: Clinical and Experimental Research, 37(3), 425–434. doi.org/10.1111/j.1530-0277.2012.01955.x Google Scholar
Horner, M.D., Ferguson, P.L., Selassie, A.W., Labbate, L.A., Kniele, K., & Corrigan, J.D. (2005). Patterns of alcohol use 1 year after traumatic brain injury: A population-based, epidemiological study. Journal of the International Neuropsychological Society, 11(3), 322–330. doi.org/10.1017/S135561770505037X CrossRefGoogle ScholarPubMed
Hua, K., Zhang, J., Wakana, S., Jiang, H., Li, X., Reich, D.S., & Mori, S. (2008). Tract probability maps in stereotaxic spaces: Analyses of white matter anatomy and tract-specific quantification. NeuroImage, 39(1), 336–347. doi.org/10.1016/j.neuroimage.2007.07.053 CrossRefGoogle ScholarPubMed
Hulkower, M.B., Poliak, D.B., Rosenbaum, S.B., Zimmerman, M.E., & Lipton, M.L. (2013). A decade of DTI in traumatic brain injury: 10 years and 100 articles later. AJNR. American Journal of Neuroradiology, 34, 2064–2074. doi.org/10.3174/ajnr.A3395 Google Scholar
Iverson, G.L., Zasler, N.D., & Lange, R.T. (2007). Post-concussive disorder. In N.D. Zasler, D. Katz, & R. Zafonte (Eds.), Brain injury medicine: Principles and practice (pp. 373–405). New York: Demos Medical Publishing.Google Scholar
Jenkinson, M., Beckmann, C.F., Behrens, T.E.J., Woolrich, M.W., & Smith, S.M. (2012). FSL. NeuroImage, 62, 782–790. doi.org/10.1016/j.neuroimage.2011.09.015 Google Scholar
Jorge, R.E., Starkstein, S.E., Arndt, S., Moser, D., Crespo-Facorro, B., & Robinson, R.G. (2005). Alcohol misuse and mood disorders following traumatic brain injury. Archives of General Psychiatry, 62(7), 742–749.CrossRefGoogle ScholarPubMed
Joseph, B., Khalil, M., Pandit, V., Kulvatunyou, N., Zangbar, B., O’Keeffe, T., & Rhee, P. (2014). Adverse effects of admission blood alcohol on long-term cognitive function in patients with traumatic brain injury. Journal of Trauma and Acute Care Surgery, 78, 403–408. doi.org/http://dx.doi.org/10.1097/TA.0000000000000504 Google Scholar
Karr, J.E., Areshenkoff, C.N., & Garcia-Barrera, M. (2014). The neuropsychological outcomes of concussion: A systematic review of meta-analyses on the cognitive sequelae of mild traumatic brain injury. Neuropsychology, 28(3), 321–336. doi.org/10.1037/neu0000037 Google Scholar
Kreutzer, J.S., Doherty, K.R., Harris, J.A., & Zasler, N.D. (1990). Alcohol use among persons with traumatic brain injury. Journal of Head Trauma Rehabilitation, 5(3), 9–21.Google Scholar
Landman, B.A., Farrell, J.A.D., Jones, C.K., Smith, S.A., Prince, J.L., & Mori, S. (2007). Effects of diffusion weighting schemes on the reproducibility of DTI-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5T. NeuroImage, 36(4), 1123–1138. doi.org/10.1016/j.neuroimage.2007.02.056 CrossRefGoogle ScholarPubMed
Lange, R.T., Iverson, G.L., & Franzen, M.D. (2007). Short-term neuropsychological outcome following uncomplicated mild TBI: Effects of day-of-injury intoxication and pre-injury alcohol abuse. Neuropsychology, 21(5), 590–598. doi.org/10.1037/0894-4105.21.5.590 CrossRefGoogle ScholarPubMed
Lange, R.T., Iverson, G.L., & Franzen, M.D. (2008). Effects of day-of-injury alcohol intoxication on neuropsychological outcome in the acute recovery period following traumatic brain injury. Archives of Clinical Neuropsychology, 23(7-8), 809–822. doi.org/10.1016/j.acn.2008.07.004 Google Scholar
Lange, R.T., Shewchuk, J.R., Rauscher, A., Jarrett, M., Heran, M.K.S., Brubacher, J.R., & Iverson, G.L. (2014). A prospective study of the influence of acute alcohol intoxication versus chronic alcohol consumption on outcome following traumatic brain injury. Archives of Clinical Neuropsychology, 29(5), 478–495. doi.org/10.1093/arclin/acu027 Google Scholar
Le Berre, A.-P., Pitel, A.-L., Chanraud, S., Beaunieux, H., Eustache, F., Martinot, J.-L., & Sullivan, E.V. (2015). Sensitive biomarkers of alcoholism’s effect on brain macrostructure: Similarities and differences between France and the United States. Frontiers in Human Neuroscience, 9, 354. doi.org/10.3389/fnhum.2015.00354 Google Scholar
Ling, J.M., Pena, A., Yeo, R.A., Merideth, F.L., Klimaj, S., Gasparovic, C., & Mayer, A.R. (2012). Biomarkers of increased diffusion anisotropy in semi-acute mild traumatic brain injury: A longitudinal perspective. Brain, 135(Pt 4), 1281–1292. doi.org/10.1093/brain/aws073 Google Scholar
Lipton, M.L., Kim, N., Park, Y.K., Hulkower, M.B., Gardin, T.M., Shifteh, K., & Branch, C.A. (2012). Robust detection of traumatic axonal injury in individual mild traumatic brain injury patients: Intersubject variation, change over time and bidirectional changes in anisotropy. Brain Imaging and Behavior, 6(2), 329–342. doi.org/10.1007/s11682-012-9175-2 Google Scholar
Mac Donald, C.L., Johnson, A.M., Cooper, D., Nelson, E.C., Werner, N.J., Shimony, J.S., & Brody, D.L. (2011). Detection of blast-related traumatic brain injury in U.S. military personnel. The New England Journal of Medicine, 364(22), 2091–2100. doi.org/10.1056/NEJMoa1008069 CrossRefGoogle ScholarPubMed
Mori, S., Wakana, S., Nagae-Poetscher, L.M., & Van Zijl, P.C.M. (2005). MRI atlas of human white matter (p. 931). Ansterdam: Elsevier. doi.org/10.1016/B978-008043924-2/50055-9 Google Scholar
Mukamal, K.J., Kuller, L.H., Fitzpatrick, A.L., Longstreth, W.T., Mittleman, M.A., & Siscovick, D.S. (2003). Prospective study of alcohol consumption and risk of dementia in older adults. The Journal of the American Medical Association, 289(11), 1405–1413. doi.org/10.1001/jama.289.11.1405 CrossRefGoogle ScholarPubMed
Nagy, J. (2008). Alcohol related changes in regulation of NMDA receptor functions. Current Neuropharmacology, 6(1), 39–54. doi.org/10.2174/157015908783769662 Google Scholar
National Institute on Alcohol Abuse and Alcoholism. (2015). What is a standard drink? Retrieved from pubs.niaaa.nih.gov/publications/practitioner/pocketguide/pocket_guide2.htm Google Scholar
O’Dell, K., Hannay, H.J., Biney, F.O.F., OʼDell, K.M., Hannay, H.J., Biney, F.O.F., & Tian, T.S. (2012). Effect of blood alcohol level and preinjury chronic alcohol use on outcome from severe traumatic brain injury in Hispanics, Anglo-Caucasians, and African-. Journal of Head Trauma Rehabilitation, 27(5), 361–369. doi.org/10.1097/HTR.0b013e318266735c.The Google Scholar
Pfefferbaum, A., Lim, K.O., Zipursky, R.B., Mathalon, D.H., Rosenbloom, M.J., Lane, B., & Sullivan, E.V. (1992). Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study. Alcoholism: Clinical and Experiemental Research, 16(6), 1078–1089. doi.org/1471762 Google Scholar
Pfefferbaum, A., Rosenbloom, M., Crusan, K., & Jernigan, T.L. (1988). Brain CT changes in alcoholics: Effects of age and alcohol consumption. Alcoholism, Clinical and Experimental Research, 12(1), 81–87. doi.org/10.1111/j.1530-0277.1988.tb00137.x Google Scholar
Pfefferbaum, A., Rosenbloom, M., Rohlfing, T., & Sullivan, E.V. (2009). Degradation of association and projection white matter systems in alcoholism detected with quantitative fiber tracking. Biological Psychiatry, 65(8), 680–690. doi.org/10.1016/j.biopsych.2008.10.039 Google Scholar
Pfefferbaum, A., & Sullivan, E.V. (2002). Microstructural but not macrostructural disruption of white matter in women with chronic alcoholism. NeuroImage, 15(3), 708–718. doi.org/10.1006/nimg.2001.1018 Google Scholar
Pfefferbaum, A., Sullivan, E.V., Hedehus, M., Adalsteinsson, E., Lim, K.O., & Moseley, M. (2000). In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. Alcoholism, Clinical and Experimental Research, 24(8), 1214–1221.Google Scholar
Ponsford, J., Tweedly, L., & Taffe, J. (2013). The relationship between alcohol and cognitive functioning following traumatic brain injury. Journal of Clinical and Experimental Neuropsychology, 35(1), 103–112. doi.org/10.1080/13803395.2012.752437 Google Scholar
Ponsford, J., Whelan-Goodinson, R., & Bahar-Fuchs, A. (2007). Alcohol and drug use following traumatic brain injury: A prospective study. Brain Injury, 21(13-14), 1385–1392. doi.org/10.1080/02699050701796960 Google Scholar
Roberts, C., Spitz, G., & Ponsford, J. (2016). Comparing prospectively recorded posttraumatic amnesia duration with retrospective accounts. Journal of Head Trauma Rehabilitation, 31(2), E71–E77. Retrieved from journals.lww.com/headtraumarehab\nhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed13&NEWS=N&AN=20160238637 CrossRefGoogle ScholarPubMed
Russell, M., Marshall, J.R., Trevisan, M., Freudenheim, J.L., Chan, A.W.K., Markovic, N., & Priore, R.L. (1997). Test-retest reliability of the cognitive lifetime drinking history. American Journal of Epidemiology, 146(11), 975–981. doi.org/10.1093/oxfordjournals.aje.a009225 Google Scholar
Sander, M., Witol, D., & Kreutzer, J.S. (1997). Alcohol use after traumatic brain injury: Concordance of patients’ and relatives’ reports. Archives of Physical Medicine and Rehabilitation, 78(2), 138–142. doi.org/10.1016/s0003-9993(97)90254-9 Google Scholar
Scheenen, M.E., de Koning, M.E., van der Horn, H.J., Roks, G., Yilmaz, T., van der Naalt, J., & Spikman, J.M. (2016). Acute alcohol intoxication in patients with mild traumatic brain injury: Characteristics, recovery and outcome. Journal of Neurotrauma, 33, 339–345. doi.org/10.2135/cropsci2013.11.0764 Google Scholar
Schutte, C., & Hanks, R. (2010). Impact of the presence of alcohol at the time of injury on acute and one-year cognitive and functional recovery after traumatic brain injury. The International Journal of Neuroscience, 120(8), 551–556. doi.org/10.3109/00207454.2010.494789 CrossRefGoogle ScholarPubMed
Shenton, M.E., Hamoda, H.M., Schneiderman, J.S., Bouix, S., Pasternak, O., Rathi, Y., & Zafonte, R. (2012). A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging and Behavior, 6(2), 137–192. doi.org/10.1007/s11682-012-9156-5 Google Scholar
Silverberg, N.D., Gardner, A., Brubacher, J.R., Panenka, W., Li, J.J., & Iverson, G.L. (2015). Systematic review of multivariable prognostic models for mild traumatic brain injury. Journal of Neurotrauma, 32(8), 517–526.Google Scholar
Smith, S.M., Jenkinson, M., Woolrich, M.W., Beckmann, C.F., Behrens, T.E.J., Johansen-Berg, H., & Matthews, P.M. (2004). Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage, 23(Suppl. 1), S208–S219. doi.org/S1053-8119(04)00393-3 [pii]\n10.1016/j.neuroimage.2004.07.051 Google Scholar
Stavro, K., Pelletier, J., & Potvin, S. (2013). Widespread and sustained cognitive deficits in alcoholism: A meta-analysis. Addiction Biology, 18(2), 203–213. doi.org/10.1111/j.1369-1600.2011.00418.x Google Scholar
Stern, R.A., & White, T. (2003). Neuropsychological assessment battery: Administration, scoring, and interpretation manual. Lutz, FL: Psychological Assessment Resources.Google Scholar
Tate, P.S., Freed, D.M., Bombardier, C.H., Harter, S.L., & Brinkman, S. (1999). Traumatic brain injury: Influence of blood alcohol level on post-acute cognitive function. Brain Injury, 13(10), 767–784. Retrieved from www.ncbi.nlm.nih.gov/pubmed/10576461 Google Scholar
Taylor, A.N., & Sutton, R.L. (2015). Evidence for beneficial and adverse effects of alcohol in animal models and clinical studies of traumatic brain injury. In Kobeissy, F.H. (Ed.), Brain neurotrauma: Molecular, neuropsychological, and rehabilitation aspects. Boca Raton, FL: CRC Press. Retrieved from www.ncbi.nlm.nih.gov/books/NBK299240/ Google Scholar
Taylor, L., Kreutzer, J.S., Demm, S.R., & Meade, M. (2003). Traumatic brain injury and substance abuse: A review and analysis of the literature. Neuropsychological Rehabilitation, 13(1-2), 165–188. doi.org/10.1080/09602010244000336 Google Scholar
Taylor, T.R., Mhlanga, J., & Thomas, A. (2009). Alcohol-related head injury: Impact on acute CT workload in a major trauma centre. British Journal of Neurosurgery, 23(6), 622–624. doi.org/10.3109/02688690903215666 Google Scholar
Teng, S.X., & Molina, P.E. (2014). Acute alcohol intoxication prolongs neuroinflammation without exacerbating neurobehavioral dysfunction following mild traumatic brain injury. Journal of Neurotrauma, 31(4), 378–386. doi.org/10.1089/neu.2013.3093 Google Scholar
Turner, A.P., Kivlahan, D.R., Rimmele, C.T., & Bombardier, C.H. (2006). Does preinjury alcohol use or blood alcohol level influence cognitive functioning after traumatic brain injury? Rehabilitation Psychology, 51(1), 78–86. doi.org/10.1037/0090-5550.51.1.78 Google Scholar
Tweedly, L., Ponsford, J., & Lee, N. (2012). Investigation of the effectiveness of brief interventions to reduce alcohol consumption following traumatic brain injury. The Journal of Head Trauma Rehabilitation, 27(5), 331–341. doi.org/10.1097/HTR.0b013e318262200a Google Scholar
Vickery, C.D., Sherer, M., Nick, T.G., Nakase-Richardson, R., Corrigan, J.D., Hammond, F., & Sander, A. (2008). Relationships among premorbid alcohol use, acute intoxication, and early functional status after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 89(1), 48–55. doi.org/10.1016/j.apmr.2007.07.047 Google Scholar
Wakana, S., Caprihan, A., Panzenboeck, M.M., Fallon, J.H., Perry, M., Gollub, R.L., & Mori, S. (2007). Reproducibility of quantitative tractography methods applied to cerebral white matter. NeuroImage, 36(3), 630–644. doi.org/10.1016/j.neuroimage.2007.02.049 Google Scholar
Wilde, E.A., Bigler, E.D., Gandhi, P.V., Lowry, C.M., Blatter, D.D., Brooks, J., & Ryser, D.K. (2004). Alcohol abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome. Journal of Neurotrauma, 21(2), 137–147. doi.org/10.1089/089771504322778604 Google Scholar
WHO. (n.d.). World Health Organization Global Status Report on Alcohol and Health 2014. Retrieved from www.who.int/substance_abuse/publications/global_alcohol_report/en/ Google Scholar
Yeh, P.H., Simpson, K., Durazzo, T.C., Gazdzinski, S., & Meyerhoff, D.J. (2009). Tract-based spatial statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: Abnormalities of the motivational neurocircuitry. Psychiatry Research - Neuroimaging, 173(1), 22–30. doi.org/10.1016/j.pscychresns.2008.07.012 Google Scholar
Yuh, E.L., Cooper, S.R., Mukherjee, P., Yue, J.K., Lingsma, H.F., Gordon, W.A., & Sinha, T.K. (2014). Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: A TRACK-TBI study. Journal of Neurotrauma, 21, 1–21. doi.org/10.1089/neu.2013.3171 Google Scholar
Zgaljardic, D.J., & Temple, R.O. (2010). Neuropsychological Assessment Battery (NAB): Performance in a sample of patients with moderate-to-severe traumatic brain injury. Applied Neuropsychology, 17(4), 283–288. doi.org/10.1080/09084282.2010.525118 Google Scholar
Zink, B.J., & Feustel, P.J. (1995). Effects of ethanol on respiratory function in traumatic brain injury. Journal of Neurosurgery, 82(5), 822–828. doi.org/10.3171/jns.1995.82.5.0822 Google Scholar
Zink, B.J., Walsh, R.F., & Feustel, P.J. (1993). Effects of ethanol in traumatic brain injury. Journal of Neurotrauma, 10(3), 275–286.CrossRefGoogle ScholarPubMed