Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-26T11:02:11.395Z Has data issue: false hasContentIssue false
  • English
  • Français

Relationship between psychiatric status and frontal–subcortical systems in HIV-infected individuals

Published online by Cambridge University Press:  20 March 2007

MICHAEL A. COLE ,
STEVEN A. CASTELLON ,
ADAM C. PERKINS ,
OSCAR S. URENO ,
MARTA B. ROBINET ,
MATTHEW J. REINHARD ,
TERRY R. BARCLAY  and
CHARLES H. HINKIN
MICHAEL A. COLE
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
STEVEN A. CASTELLON
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
ADAM C. PERKINS
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
OSCAR S. URENO
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
MARTA B. ROBINET
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
MATTHEW J. REINHARD
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
TERRY R. BARCLAY
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
CHARLES H. HINKIN
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California
Get access Rights & Permissions [Opens in a new window]

Abstract

Human immunodeficiency virus (HIV)-infected adults frequently evidence both neurocognitive and psychiatric dysfunction. It was hypothesized that apathy and irritability, but not anxiety and depression, are related to HIV effects on frontal–subcortical systems. This hypothesis was evaluated by determining the degree to which these psychiatric features are associated with neurocognitive functioning that is dependent upon frontal–subcortical circuitry and, therefore, thought to be sensitive to the central nervous system effects of HIV. Rating scales assessing irritability, apathy, depression, and anxiety and a dual-task paradigm were administered to 189 HIV-seropositive (HIV+) and 53 HIV-seronegative participants. Deficits in dual-task performance and greater anxiety, depression, apathy, and irritability were observed in HIV+ participants. Simultaneous multivariate regression and communality analyses revealed that only apathy and irritability were associated with dual-task performance in HIV+ participants. Thus, these findings suggest that apathy and irritability, but not depression and anxiety, are likely associated with the effects of HIV on frontal–subcortical circuitry. (JINS, 2007, 13, 549–554.)

Keywords

Human immunodeficiency virusApathyIrritabilityDepressionAnxietyCognition
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 3 , May 2007 , pp. 549 - 554
Copyright
© 2007 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Absher, J.R. & Cummings, J.L. (1995). Neurobehavioral examination of frontal lobe functions. Aphasiology, 9, 181–192.Google Scholar
Baddeley, A., Della Sala, S., Papagno, C., & Spinnler, H. (1997). Dual-task performance in dysexecutive and nondysexecutive patients with a frontal lesion. Neuropsychology, 11, 187–194.Google Scholar
Beck, A.T., Epstein, N., Brown, G., & Steer, R.A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897.Google Scholar
Beck, A.T., Steer, R.A., & Brown, G.K. (1996). Manual for Beck Depression Inventory II (BDI-II). San Antonio, TX: Psychology Corporation.
Belsey, D.A., Kuh, E., & Welsch, R.E. (1980). Regression diagnostics: Identifying influential data and sources of collinearity. Hoboken, NJ: Wiley.
Castellon, S.A., Hinkin, C.H., & Myers, H.F. (2000). Neuropsychiatric disturbance is associated with executive dysfunction in HIV-1 infection. Journal of the International Neuropsychological Society, 6, 336–347.Google Scholar
Castellon, S.A., Hinkin, C.H., Wood, S., & Yarema, K.T. (1998). Apathy, depression, and cognitive performance in HIV-1 infection. The Journal of Neuropsychiatry and Clinical Neurosciences, 10, 320–329.Google Scholar
Chandra, P.S., Desai, G., & Ranjan, S. (2005). HIV and psychiatric disorders. The Indian Journal of Medical Research, 121, 451–467.Google Scholar
Cummings, J.L. (1993). Frontal-subcortical circuits and human behavior. Archives of Neurology, 50, 873–880.Google Scholar
Cummings, J.L. (1997). Changes in neuropsychiatric symptoms as outcome measures in clinical trails with cholinergic therapies for Alzheimer disease. Alzheimer Disease and Associated Disorders, 11, S1–S9.Google Scholar
Cummings, J.L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D.A., & Gornbein, J. (1994). The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology, 44, 2308–2314.Google Scholar
Della Sala, S., Baddeley, A., Papagno, C., & Spinnler, H. (1995). Dual-task paradigm: A means to examine the central executive. Annals of the New York Academy of Sciences, 769, 161–171.Google Scholar
Grant, I., Olshen, R.A., Atkinson, J.H., Heaton, R.K., Nelson, J., McCuthchan, J.A., & Weinrich, J.D. (1993). Depressed mood does not explain neuropsychological deficits in HIV-infected persons. Neuropsychology, 7, 53–61.Google Scholar
Hinkin, C.H., Castellon, S.A., & Hardy, D.J. (2000). Dual task performance in HIV-1 infection. Journal of Clinical and Experimental Neuropsychology, 22, 16–24.Google Scholar
Hinkin, C.H., Van Gorp, W.G., Satz, P., Weisman, J.D., Thommes, J., & Buckingham, S. (1992). Depressed mood and its relationship to neuropsychological test performance in HIV-1 seropositive individuals. Journal of Clinical and Experimental Neuropsychology, 14, 289–297.Google Scholar
Mapou, R.L., Law, W.A., Martin, A., Kampen, D., Salazar, A.M., & Rundell, J.R. (1993). Neuropsychological performance, mood, and complaints of cognitive and motor difficulties in individuals infected with the human immunodeficiency virus. Journal of Neuropsychiatry and Clinical Neurosciences, 5, 86–93.Google Scholar
Paul, R.H., Brickman, A.M., Navia, B., Hinkin, C., Malloy, P.F., Jefferson, A.L., Cohen, R.A., Tate, D.F., & Flanigan, T.P. (2005b). Apathy is associated with volume of the nucleus accumbens in patients with HIV. Journal of Neuropsychiatry and Clinical Neurosciences, 17, 167–171.Google Scholar
Paul, R., Flanigan, T.P., Tashima, K., Cohen, R., Lawrence, J., Alt, E., Tate, D., Ritchie, C., & Hinkin, C. (2005a). Apathy correlates with cognitive function but not CD4 status in patients with human immunodeficiency virus. Journal of Neuropsychiatry and Clinical Neurosciences, 17, 114–118.Google Scholar
Pedhazur, E.J. (1982). Multiple region in behavioral research: Explanation and prediction (2nd ed.). New York: Holt, Renehart & Winston.
Perdices, M., Dunbar, N., Grunseit, A., Hall, W., & Cooper, D.A. (1992). Anxiety, depression and HIV related symptomatology across the spectrum of HIV disease. The Australian and New Zealand Journal of Psychiatry, 26, 560–566.Google Scholar
Rabkin, J.G., Ferrando, S.J., Van Gorp, W., Rieppi, R., McElhiney, M., & Sewell, M. (2000). Relationships among apathy, depression, and cognitive impairments in HIV/AIDS. Journal of Neuropsychiatry and Clinical Neurosciences, 12, 451–457.Google Scholar
Thompson, P.M., Dutton, R.A., Hayashi, K.M., Toga, A.W., Lopez, O.L., Aizenstein, H.J., & Becker, J.T. (2005). Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proceedings of the National Academy of Sciences of the United States of America, 102, 15647–15652.Google Scholar