Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-23T04:56:43.830Z Has data issue: false hasContentIssue false

Quality of life, emotional, and cognitive function following acute respiratory distress syndrome

Published online by Cambridge University Press:  01 November 2004

RAMONA O. HOPKINS
Affiliation:
Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah Psychology Department and Neuroscience Center, Brigham Young University, Provo, Utah
LINDELL K. WEAVER
Affiliation:
Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah
KAREN J. CHAN
Affiliation:
Statistical Data Center, LDS Hospital, Salt Lake City, Utah
JAMES F. ORME
Affiliation:
Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah

Abstract

Acute Respiratory Distress Syndrome (ARDS) is characterized by lung injury and hypoxemia, has a high mortality rate, and is associated with significant morbidity including cognitive and emotional sequelae and decreased quality of life. There is limited information regarding which of these factors are associated with decreased quality of life. This study assessed the relationships between quality of life, cognitive and emotional function in ARDS survivors at 1-year post-hospital discharge. Sixty-six ARDS survivors were administered a battery of neuropsychological tests, measures of emotional function and quality of life 1 year post-hospital discharge. At 1 year 45% of the ARDS patients had cognitive sequelae and 29% had mild to moderate symptoms of depression and anxiety. Depression, anxiety, and intensive care unit length of stay were significantly correlated with decreased quality of life. Cognitive impairments did not correlate with decreased quality of life. Illness severity and emotional function, but not cognitive sequelae, are associated with decreased quality of life 1 year following ARDS. ARDS is common and may result in significant cognitive and emotional morbidity and decreased quality of life. (JINS, 2004, 10, 1005–1017.)

Type
SYMPOSIA ARTICLE
Copyright
© 2004 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Abel, S.J., Finney, S.J., Brett, S.J., Keogh, B.F., Morgan, C.J., & Evans, T.W. (1998). Reduced mortality in association with the acute respiratory distress syndrome (ARDS). Thorax, 53, 292294.Google Scholar
Albert, S.M., Michaels, K., Padilla, M., Pelton, G., Bell, K., Marder, K., Stern, Y., & Devanand, D.P. (1997). Functional significance of mild cognitive impairment in elderly patients without a dementia diagnosis. American Journal of Geriatric Psychiatry, 7, 213220.Google Scholar
Al-Saidi, F., McAndrews, M.P., Cheunt, A.M., Tansey, C.M., Matte-Martyn, A., Diaz-Granados, N., & Herridge, M.S. (2003). Neuropsychological sequelae in ARDS survivors. American Journal of Respiratory and Critical Care Medicine, 167, A737.Google Scholar
Angus, D.C., Musthafa, A.A., Clermont, G., Griffin, M.F., Linde-Zwirble, W.T., Dremsizov, T., & Pinsky, M.R. (2001). Quality-adjusted survival in the first year after the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 163, 13891394.Google Scholar
Beck, A. (1996). BDI–II Depression Inventory manual (2nd ed.). New York: Harcourt-Brace.
Beck, A. & Steer, R.A. (1993). Beck Anxiety Inventory. San Antonio, TX: The Psychological Corporation.
Bernard, G.R., Artigas, A., Brigham, K.L., Carlet, J., Falle, K., Hudson, L., Lamy, M., LeGall, J.R., Morris, A., & Spragg, R. (1994). Report of the American-European Consensus Conference on acute respiratory distress syndrome: Definitions, mechanics, relevant outcomes, and clinical trial coordination. American Journal of Respiratory Critical Care Medicine, 149, 818824.Google Scholar
Churchill, S., Hopkins, R.O., Weaver, L.K., Chan, K.J., & Haberstock, D. (2002). Health related quality of life (HRQL) following carbon monoxide poisoning. Undersea and Hyperbaric Medicine, 29, 139140.Google Scholar
Combes, A., Costa, M.A., Trouillet, J.L., Baudot, J., Mokhtari, M., Gibert, C., & Chastre, J. (2003). Morbidity, mortality, and quality-of-life outcomes of patients requiring > or = 14 days of mechanical ventilation. Critical Care Medicine, 31, 13731381.Google Scholar
Cooper, A.B., Ferguson, N.D., Hanly, P., Meade, M.O., Kachura, J.R., Granton, J.T., Slutsky, A.S., & Stewart, T.E. (1999). Long-term follow-up of survivors of acute lung injury: Lack of effect of a ventilation strategy to prevent barotrauma. Critical Care Medicine, 27, 26162621.Google Scholar
Craven, J.L., Rodin, G.M., & Littlefield, C. (1988). The Beck Depression Inventory as a screening device for major depression in renal dialysis patients. International Journal of Psychiatry Medicine, 18, 365374.Google Scholar
Davidson, T.A., Caldwell, E.S., Curtis, J.R., Hudson, L.D., & Steinberg, K.P. (1999). Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients. Journal of the American Medical Association, 281, 354360.Google Scholar
Ely, E.W., Shintani, A., Truman, B., Speroff, T., Gordon, S.M., Harrell, F., Jr., Inouye, S.K., Bernard, G.R., & Dittus, R.S. (2004). Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. Journal of the American Medical Association, 291, 17531762.Google Scholar
Foa, E.B., Riggs, D.S., Dancu, C.V.S., & Rothbaum, B.O. (1993). Reliability and validity of a brief instrument for assessing Post Traumatic Stress Disorder. Journal of Traumatic Stress, 6, 459473.Google Scholar
Frasure-Smith, N., Lesperance, F., & Talajic, M. (1995). The impact of negative emotions on prognosis following myocardial infarction: Is it more than depression? Health Psychology, 14, 388398.Google Scholar
Gale, S.D. & Hopkins, R.O. (2004). Effects of hypoxia on the brain: Neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea. Journal of the International Neuropsychological Society, 10, 6071.Google Scholar
Gale, S.D., Hopkins, R.O., Weaver, L.K., Walker, J.M., Bigler, E.D., & Cloward, T.V. (2000). Hippocampal atrophy following sleep apnea and carbon monoxide poisoning: similarities and differences. Journal of International Neuropsychological Society, 6, 154.Google Scholar
Gold, P.W., Licinio, J., Wong, M.L., & Chrousos, G.P. (1995). Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. Annals of the New York Academy of Sciences, 771, 716729.Google Scholar
Green, A., Felmingham, K., Baguley, I.J., Slewa-Younan, S., & Simpson, S. (2001). The clinical utility of the Beck Depression Inventory after traumatic brain injury. Brain Injury, 15, 10211028.Google Scholar
Griffith, H.R., Belue, K., Sicola, A., Krzywanski, S., Zamrini, E., Harrell, L., & Marson, D.C. (2003). Impaired financial abilities in mild cognitive impairment: A direct assessment approach. Neurology, 60, 449457.Google Scholar
Groth-Marnat, G. (1990). Handbook of psychological assessment (2nd ed.). New York: John Wiley and Sons.
Heaton, R.K. (1994). Comprehensive norms for an Expanded Halstead–Reitan Battery: A supplement for the WAIS–R. Odessa, FL: Psychological Assessment Resources, Inc.
Heaton, R.K., Grant, I., & Matthews, C.G. (1991). Comprehensive norms for an Expanded Halstead-Reitan Battery: Demographic corrections, research findings, and clinical applications. Odessa, FL: Psychological Assessment Resources, Inc.
Heaton, R.K., Temkin, N., Dikmen, S., Avitable, N., Taylor, M.J., Marcotte, T.D., & Grant, I. (2001). Detecting change: A comparison of three neuropsychological methods, using normal and clinical samples. Archives of Clinical Neuropsychology, 16, 7591.Google Scholar
Herridge, M.S., Cheung, A.M., Tansey, C.M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A.B., Guest, C.B., Mazer, C.D., Mehta, S., Stewart, T.E., Barr, A., Cook, D., Slutsky, A.S., & the Canadian Critical Care Trials Group. (2003). One-year outcomes in survivors of the acute respiratory distress syndrome. New England Journal of Medicine, 348, 683693.Google Scholar
Heyland, D.K., Hopman, W., Coo, H., Tranmer, J., & McColl, M.A. (2000). Long-term health-related quality of life in survivors of sepsis. Short form 36: A valid and reliable measure of health-related quality of life. Critical Care Medicine, 28, 35993605.Google Scholar
Hopkins, R.O., Larson-Lohr, V., Weaver, L.K., & Bigler, E.D. (1998). Neuropsychological impairments following hantavirus pulmonary syndrome. Journal of the International Neuropsychological Society, 4, 190196.Google Scholar
Hopkins, R.O., Weaver, L.K., Pope, D., Orme, J.F., Bigler, E.D., & Larson, L.V. (1999). Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 160, 5056.Google Scholar
Jackson, J.C., Hart, R.P., Gordon, S.M., Shintani, A., Truman, B., May, L., & Ely, E.W. (2003). Six-month neuropsychological outcome of medical intensive care unit patients. Critical Care Medicine, 31, 12261234.Google Scholar
Kabacoff, R.I., Segal, D.L., Hersen, M., & Van Hasselt, V.B. (1997). Psychometric properties and diagnostic utility of the Beck Anxiety Inventory and the State–Trait Anxiety Inventory with old adult psychiatric outpatients. Journal of Anxiety Disorders, 1, 3347.Google Scholar
Kapfhammer, H.P., Rothenhausler, H.B., Krauseneck, T., Stoll, C., & Schelling, G. (2004). Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome. American Journal of Psychiatry, 161, 4552.Google Scholar
Karajgi, B., Rifkin, A., Doddi, S., & Kolli, R. (1990). The prevalence of anxiety disorders in patients with chronic obstructive pulmonary disease. American Journal of Psychiatry, 147, 200201.Google Scholar
Katon, W. & Sullivan, M.D. (1990). Depression and chronic medical illness. Journal of Clinical Psychiatry, 51 (Suppl.), 314.Google Scholar
Katz, I.R. (1982). Is there a hypoxic affective syndrome? Psychosomatics, 23, 846853.Google Scholar
Katz, I.R. (1996). On the inseparability of mental and physical health in aged persons: Lessons from depression and medical comorbidity. American Journal of Geriatric Psychiatry, 4, 116.Google Scholar
Knaus, W.A., Draper, E.A., Wagner, D.P., & Zimmerman, J.E. (1985). APACHE II: A severity of disease classification system. Critical Care Medicine, 13, 818829.Google Scholar
Kwa, V.I., Limburg, M., & de Haan, R.J. (1996a). The role of cognitive impairment in the quality of life after ischaemic stroke. Journal of Neurology, 243, 599604.Google Scholar
Kwa, V.I., Limburg, M., Voogel, A.J., Teunisse, S., Derix, M.M., & Hijdra, A. (1996b). Feasibility of cognitive screening of patients with ischaemic stroke using the CAMCOG. A hospital-based study. Journal of Neurology, 243, 405409.Google Scholar
Marquis, K., Curtis, J., Caldwell, E., Davidson, T., Davis, J., Sanchez, P., Rosenbaum, G., Hudson, L.D., & Steinberg, K.P. (2000). Neuropsychological sequelae in survivors of ARDS compared with critically ill control patients. American Journal of Respiratory and Critical Care Medicine, 161, A383.Google Scholar
McCartney, J.R. & Boland, R.J. (1994). Anxiety and delirium in the intensive care unit. Critical Care Clinics, 10, 673680.Google Scholar
McHugh, L.G., Milberg, J.A., Whitcomb, M.E., Schoene, R.B., Maunder, R.J., & Hudson, L.D. (1994). Recovery of function in survivors of the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 150, 9094.Google Scholar
McSweeny, A.J., Grant, I., Heaton, R.K., Prigatano, G.P., & Adams, K. (1985). Relationship of neuropsychological status to everyday functioning in healthy and chronically ill persons. Journal of Clinical and Experimental Neuropsychology, 7, 281291.Google Scholar
McSweeny, A.J. & Labuhn, K.T. (1996). The relationship of neuropsychological functioning to life quality in systemic medical disease: The example of chronic obstructive pulmonary disease. In I. Grant & K.M. Adams (Eds.), Neuropsychological assessment in neuropsychiatry (pp. 577602). New York: Oxford, University Press.
Michaels, A.J., Michales, C.E., Smith, J.S., Moon, C.H., Peterson, C., & Long, W.B. (2000). PTSD in critical care. Journal of Trauma, 48, 841850.Google Scholar
Milberg, J.A., Davis, D.R., Steinberg, K.P., & Hudson, L.D. (1995). Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983–1993. Journal of the American Medical Association, 273, 306309.Google Scholar
Milisen, K., Foreman, M.D., Abraham, I.L., Geest, S.D., Bodderis, J., Vandermeulen, E., Fischler, B., Delooz, H.H., Spiessens, B., & Broos, P.L. (2001). A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. Journal of the American Geriatrics Society, 49, 523532.Google Scholar
Morrison, M.F. & Kastenberg, J.S. (1997). Differentiation of secondary for primary mood disorders: Controversies and consensus. Seminars in Clinical Neuropsychiatry, 2, 232243.Google Scholar
National Research Council. (2000). The aging mind: Opportunities in cognitive research. Washington, DC: National Academy of Press.
Naugle, R.I., Cullum, C.M., & Bigler, E. (1998). Introduction to clinical neuropsychology: A Case book. Austin, TX: Pro-Ed.
Nelson, B.J., Weinert, C.R., Bury, C.L., Marinelli, W.A., & Gross, C.R. (2000). Intensive care unit drug use and subsequent quality of life in acute lung injury patients. Critical Care Medicine, 28, 36263630.Google Scholar
Newman, M., Grocott, H., Mathew, J., White, W., Landolfo, K., Reves, J., (2001a). Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke, 32, 28742881.Google Scholar
Newman, M., Kirchner, J., Phillips-Bute, B., Gaver, V., Grocott, H., Jones, R.H., Mark, D.B., Reves, J.G., Blumenthal, J.A., & The Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators. (2001b). Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. New England Journal of Medicine, 344, 395402.Google Scholar
Nygard, L. (2003). Instrumental activities of daily living: A stepping stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment? Acta Neurologica Scandinavia, 179, S42S46.Google Scholar
Oniki, T.A. & Gardner, R.M. (1994). Computerized detection of arterial oxygen desaturations in an intensive care unit. Proceedings of the Annual Symposium of Computer Applications in Medical Care, 307311.
Orme, J., Jr., Romney, J.S., Hopkins, R.O., Pope, D., Chan, K.J., Thomsen, G., Crapo, R.O., & Weaver, L.K. (2003). Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 167, 690694.Google Scholar
Osowiecki, D.M., Cohen, R.A., Morrow, K.M., Paul, R.H., Carpenter, C.C., Flanigan, T., & Boland, R.J. (2000). Neurocognitive and psychological contributions to quality of life in HIV-1-infected women. Aids, 14, 13271332.Google Scholar
Pearlson, G.D., Rabins, P.V., Kim, W.S., Speedie, L.J., Moberg, P.J., Burns, A., & Bascom, M.J. (1989). Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’). Psychological Medicine, 19, 573584.Google Scholar
Petty, T.L. & Ashbaugh, D.G. (1971). The adult respiratory distress syndrome: Clinical features and factors influencing prognosis and principles of management. Chest, 60, 233239.Google Scholar
Pollack, M.H., Kradin, R., Otto, M.W., Worthington, J., Gould, R., Sabatino, S.A., & Rosenbaum, J.F. (1996). Prevalence of panic in patients referred for pulmonary function testing at a major medical center. American Journal of Psychiatry, 153, 110113.Google Scholar
Rincon, H.G., Granados, M., Unutzer, J., Gomez, M., Duran, R., Badiel, M., Salas, C., Martinez, J., Mejia, J., Ordonez, C., Florez, N., Rosso, F., & Echeverri, P. (2001). Prevalence, detection and treatment of anxiety, depression, and delirium in the adult critical care unit. Psychosomatics, 42, 391396.Google Scholar
Rockwood, K., Brown, M., Merry, H., Sketris, I., & Fisk, J. (2002). Societal costs of vascular cognitive impairment in older adults. Stroke, 33, 16051609.Google Scholar
Rothenhausler, H.B., Ehrentraut, S., Stoll, C., Schelling, G., & Kapfhammer, H.P. (2001). The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: Results of an exploratory study. General Hospital Psychiatry, 23, 9096.Google Scholar
Rubenfeld, G.D. (2003). Epidemiology of acute lung injury. Critical Care Medicine, 31 (Suppl.), S276S284.Google Scholar
Rubenfeld, G.D., Doyle, R.L., & Matthay, M.A. (1995). Evaluation of definitions of ARDS. American Journal of Respiratory and Critical Care Medicine, 151, 12701271.Google Scholar
Schelling, G., Richter, M., Roozendaal, B., Rothenhausler, H.B., Krauseneck, T., Stoll, C., Nollert, G., Schmidt, M., & Kapfhammer, H.P. (2003). Exposure to high stress in the intensive care unit may have negative effects on health-related quality-of-life outcomes after cardiac surgery. Critical Care Medicine, 31, 19711980.Google Scholar
Schelling, G., Stoll, C., Haller, M., Briegel, J., Manert, W., Hummel, T., Lenhart, A., Heyduck, M., Polaset, J., Meier, M., Preuss, U., Bullinger, M., Schuffel, W., & Peter, K. (1998). Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Critical Care Medicine, 26, 651659.Google Scholar
Scragg, P., Jones, A., & Fauvel, N. (2001). Psychological problems following ICU treatment. Anaesthesia, 56, 914.Google Scholar
Silverstone, P.H. (1996). Prevalence of psychiatric disorders in medical inpatients. Journal of Nervous and Mental Disease, 184, 4351.Google Scholar
Silverstone, P.H., Lemay, T., Elliott, J., Hsu, V., & Starko, R. (1996). The prevalence of major depressive disorder and low self-esteem in medical inpatients. Canadian Journal of Psychiatry, 41, 6774.Google Scholar
Skodol, A.E. (1999). Anxiety in the medically ill: Nosology and principles of differential diagnosis. Seminars in Clinical Neuropsychiatry, 4, 6471.Google Scholar
Stewart, A., Hays, R., & Ware, J. (1988). The MOS short form general health survey: Reliability and validity in a patient population. Medical Care, 26, 724732.Google Scholar
Strain, J.J., Liebowitz, M.R., & Klein, D.F. (1981). Anxiety and panic attacks in the medically ill. Psychiatric Clinics of North America, 4, 333350.Google Scholar
Streadman-Pare, D., Colantonio, A., Ratcliff, G., Chase, S., & Vernich, L. (2000). Factors associated with perceived quality of life many years after traumatic brain injury. Journal of Head Trauma Rehabilitation, 16, 330342.Google Scholar
Suchyta, M.R., Clemmer, T., Orme, J.F., Jr., Morris, A.H., & Elliott, C.G. (1991). Increased survival of ARDS patients with severe hypoxemia (ECMO criteria). Chest, 99, 951955.Google Scholar
Suchyta, M.R., Elliott, C.G., Jensen, R.L., & Crapo, R.O. (1993). Predicting the presence of pulmonary function impairment in adult respiratory distress syndrome survivors. Respiration, 60, 103108.Google Scholar
Szokol, J.W. & Vender, J.S. (2001). Anxiety, delirium, and pain in the intensive care unit. Critical Care Clinics, 17, 821842.Google Scholar
Tabert, M.H., Albert, S.M., Borukhova-Milov, B.A., Camacho, Y., Pelton, G., Liu, X., Stern, Y., & Devanand, D.P. (2002). Functional deficits in patients with mild cognitive impairments: Prediction of AD. Neurology, 58, 758764.Google Scholar
Temkin, N.R., Heaton, R.K., Grant, I., & Dikmen, S.S. (1999). Detecting significant change in neuropsychological test performance: A comparison of four models. Journal of the International Neuropsychological Society, 5, 357369.Google Scholar
Thiagarajan, J. & Miranda, D.R. (1995). Quality of life after multiple trauma requiring intensive care. Anaesthesia, 49, 211218.Google Scholar
Toshima, M.T., Blumberg, E., Ries, A.L., & Kaplan, R.M. (1992). Does rehabilitation reduce depression in patients with chronic obstructive pulmonary disease? Journal of Cardiopulmonary Rehabilitation, 12, 261269.Google Scholar
Ware, J.E. (1993). SF-36 Health Survey manual and interpretation guide. Boston: The Health Institute, New England Medical Center.
Ware, J.E., Kosinski, M., & Keller, S.D. (1994). SF-36 Physical and Mental Health Summary Scales: A user's manual. Boston: The Health Institute, New England Medical Center.
Warren, L., Wrigley, J.M., Yoels, W.C., & Fine, P.R. (1996). Factors associated with life satisfaction among a sample of persons with neurotrauma. Journal of Rehabilitation Research and Development, 33, 404408.Google Scholar
Weaver, L.K., Hopkins, R.O., Chan, K.J., Churchill, S., Elliott, C.G., Clemmer, T.P., Orme, J.F., Jr., Thomas, F.O., & Morris, A.H. (2002). Hyperbaric oxygen for acute carbon monoxide poisoning. New England Journal of Medicine, 347, 10571067.Google Scholar
Weinert, C.R., Chlan, L., & Gross, C. (2001). Sedating critically ill patients: Factors affecting nurses' delivery of sedative therapy. American Journal of Critical Care, 10, 156167.Google Scholar
Weinert, C.R., Gross, C.R., Kangas, J.R., Cury, C.L., & Marinelli, W.A. (1997). Health-related quality of life after acute lung injury. American Journal of Respiratory and Critical Care Medicine, 156, 11201128.Google Scholar