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Predictors of cognitive function in candidates for coronary artery bypass graft surgery

Published online by Cambridge University Press:  02 February 2007

CHRISTINE S. ERNEST ,
PETER C. ELLIOTT ,
BARBARA M. MURPHY ,
MICHAEL R. LE GRANDE ,
ALAN J. GOBLE ,
ROSEMARY O. HIGGINS ,
MARIAN U.C. WORCESTER  and
JAMES TATOULIS
CHRISTINE S. ERNEST
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia
PETER C. ELLIOTT
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia Australian Centre for Posttraumatic Mental Health, The University of Melbourne, Victoria, Australia
BARBARA M. MURPHY
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia Department of Psychiatry, The University of Melbourne, Victoria, Australia
MICHAEL R. LE GRANDE
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia
ALAN J. GOBLE
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia
ROSEMARY O. HIGGINS
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia
MARIAN U.C. WORCESTER
Affiliation:
Heart Research Centre, Melbourne, Victoria, Australia Department of Psychology, The University of Melbourne, Victoria, Australia
JAMES TATOULIS
Affiliation:
Department of Cardiothoracic Surgery, The Royal Melbourne Hospital, Victoria, Australia
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Abstract

Candidates for coronary artery bypass graft surgery have been found to exhibit reduced cognitive function prior to surgery. However, little is known regarding the factors that are associated with pre-bypass cognitive function. A battery of neuropsychological tests was administered to a group of patients listed for bypass surgery (n = 109). Medical, sociodemographic and emotional predictors of cognitive function were investigated using structural equation modeling. Medical factors, namely history of hypertension and low ejection fraction, significantly predicted reduced cognitive function, as did several sociodemographic characteristics, namely older age, less education, non-English speaking background, manual occupation, and male gender. One emotional variable, confusion and bewilderment, was also a significant predictor whereas anxiety and depression were not. When significant predictors from the three sets of variables were included in a combined model, three of the five sociodemographic characteristics, namely age, non-English speaking background and occupation, and the two medical factors remained significant. Apart from sociodemographic characteristics, medical factors such as a history of hypertension and low ejection fraction significantly predicted reduced cognitive function in bypass candidates prior to surgery. (JINS, 2007, 13, 257–266.)

Keywords

Cardiac patientsCoronary heart diseasePre-operative cognitionCognitive impairmentRisk factorsCognitive manifestation
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 2 , March 2007 , pp. 257 - 266
Copyright
© 2007 The International Neuropsychological Society

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