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Neural hybrid model of semantic object memory: Implications from event-related timing using fMRI

Published online by Cambridge University Press:  12 February 2004

MICHAEL A. KRAUT ,
VINCE CALHOUN ,
JEFFERY A. PITCOCK ,
CATHERINE CUSICK  and
JOHN HART
MICHAEL A. KRAUT
Affiliation:
Dept. of Radiology, Division of Neuroradiology, The Johns Hopkins University School of Medicine, Baltimore, MD
VINCE CALHOUN
Affiliation:
Dept. of Psychiatry, Yale University, New Haven, CT
JEFFERY A. PITCOCK
Affiliation:
Depts. of Geriatrics, Neurology, and Radiology, Donald. W. Reynolds Center on Aging, University of Arkansas for Medical Science, Little Rock, AR
CATHERINE CUSICK
Affiliation:
Dept. of Structural and Cellular Biology, Neuroscience Program, Tulane University, New Orleans, LA
JOHN HART
Affiliation:
Depts. of Geriatrics, Neurology, and Radiology, Donald. W. Reynolds Center on Aging, University of Arkansas for Medical Science, Little Rock, AR
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Abstract

Previous studies by our group have demonstrated fMRI signal changes and synchronized gamma rhythm EEG oscillations between thalamus and cortical regions as subjects recall objects from visually presented features. Here, we extend this work by estimating the time course of fMRI signal changes in the cortical and subcortical regions found to exhibit evidence for task-related activation. Our results indicate that there are separate loci of signal changes in the thalamus (dorsomedial and pulvinar) that exhibit notable differences in times of onset, peak and return to baseline of signal changes. The signal changes in the pulvinar demonstrate the slowest transients of all the cortical and subcortical regions we examined. Evaluation of cortical regions demonstrated salient differences as well, with the signal changes in Brodmann area 6 (BA6) rising, peaking, and returning to baseline earlier than those detected in other regions. We conclude that BA6 mediates early designation or refinement of search criteria, and that the pulvinar may be involved in the binding of feature stimuli for an integrated object memory. (JINS, 2003, 9, 1031–1040.)

Keywords

Semantic memoryThalamusfMRI
Type
THEMATIC ARTICLES
Information
Journal of the International Neuropsychological Society , Volume 9 , Issue 7 , November 2003 , pp. 1031 - 1040
Copyright
© 2003 The International Neuropsychological Society

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References

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