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Learning in children and sleep disordered breathing: Findings of the Tucson Children's Assessment of Sleep Apnea (TuCASA) Prospective Cohort Study

Published online by Cambridge University Press:  12 February 2004

KRIS L. KAEMINGK ,
ALICE E. PASVOGEL ,
JAMES L. GOODWIN ,
SHELAGH A. MULVANEY ,
FERNANDA MARTINEZ ,
PAUL L. ENRIGHT ,
GERALD M. ROSEN ,
WAYNE J. MORGAN ,
RALPH F. FREGOSI  and
STUART F. QUAN
KRIS L. KAEMINGK
Affiliation:
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona Steele Memorial Children's Research Center, University of Arizona, Tucson, Arizona
ALICE E. PASVOGEL
Affiliation:
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona
JAMES L. GOODWIN
Affiliation:
Arizona Respiratory Center, University of Arizona, Tucson, Arizona
SHELAGH A. MULVANEY
Affiliation:
Department of Psychology, University of Arizona, Tucson, Arizona
FERNANDA MARTINEZ
Affiliation:
Arizona Respiratory Center, University of Arizona, Tucson, Arizona
PAUL L. ENRIGHT
Affiliation:
Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona
GERALD M. ROSEN
Affiliation:
Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota
WAYNE J. MORGAN
Affiliation:
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona Arizona Respiratory Center, University of Arizona, Tucson, Arizona
RALPH F. FREGOSI
Affiliation:
Department of Physiology, University of Arizona, Tucson, Arizona
STUART F. QUAN
Affiliation:
Arizona Respiratory Center, University of Arizona, Tucson, Arizona Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona Sleep Disorders Center, University of Arizona, Tucson, Arizona
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Abstract

We examined the relationship between nocturnal respiratory disturbance and learning and compared learning in children with and without nocturnal respiratory disturbance. Subjects were 149 participants in a prospective cohort study examining sleep in children ages 6–12: The Tucson Children's Assessment of Sleep Apnea study (TuCASA). Sleep was assessed via home polysomnography. Intelligence, learning and memory, and academic achievement were assessed. Parents rated attention. Group comparisons were used to test the hypothesis that the group with an apnea/hypopnea index (AHI) of 5 or more (n = 77) would have weaker performance than the group with AHI less than 5 (n = 72). The group with AHI of 5 or more had weaker learning and memory though differences between groups decreased when arousals were taken into account. There was a greater percentage of Stage 1 sleep in the AHI 5 or more group, and Stage 1 percentage was negatively related to learning and memory in the sample (n = 149). There were negative relationships between AHI and immediate recall, Full Scale IQ, Performance IQ, and math achievement. Hypoxemia was associated with lower Performance IQ. Thus, findings suggest that nocturnal respiratory disturbance is associated with decreased learning in otherwise healthy children, that sleep fragmentation adversely impacts learning and memory, and that hypoxemia adversely influences nonverbal skills. (JINS, 2003, 9, 1016–1026.)

Keywords

LearningMemorySleep disordered breathingApneaChildren
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 9 , Issue 7 , November 2003 , pp. 1016 - 1026
Copyright
© 2003 The International Neuropsychological Society

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