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Empathic deficits in schizophrenia: The potential role of rapid facial mimicry

Published online by Cambridge University Press:  07 April 2010

KANDICE J. VARCIN*
Affiliation:
School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
PHOEBE E. BAILEY
Affiliation:
School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
JULIE D. HENRY
Affiliation:
School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
*
*Correspondence and reprint requests to: Kandice J. Varcin, School of Psychology, University of New South Wales, Sydney, New South Wales 2052 Australia. E-mail: [email protected]

Abstract

Emotional facial expressions evoke rapid, involuntary, and covert facial reactions in the perceiver that are consistent with the emotional valence of the observed expression. These responses are believed to be an important low-level mechanism contributing to the experience of empathy, which some have argued rely on a simulation mechanism subserved by the human mirror neuron system (MNS). Because schizophrenia is associated with pervasive social cognitive difficulties which have been linked to structural abnormalities in the MNS network, the aim of the present study was to provide the first assessment of how rapid facial mimicry reactions (within 1000 ms poststimulus onset) are affected in schizophrenia. Activity in the corrugator supercilii and zygomaticus major muscle regions was quantified using electromyography while individuals with schizophrenia (n = 25) and controls (n = 25) viewed images of happy and angry facial expressions. In contrast to controls, individuals with schizophrenia demonstrated atypical facial mimicry reactions which were not associated with any clinical features of the disorder. These data provide evidence for a low-level disruption that may be contributing to empathizing deficits in schizophrenia and are discussed in relation to neuropsychological models of empathy and schizophrenia. (JINS, 2010, 16, 621–629.)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 2010

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References

REFERENCES

Adolphs, R. (2002). Neural systems for recognizing emotion. Current Opinion in Neurobiology, 12, 169177.CrossRefGoogle ScholarPubMed
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
Andreasen, N.C. (1984a). Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa.Google Scholar
Andreasen, N.C. (1984b). Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa.Google Scholar
Bailey, P.E., & Henry, J.D. (2009). Subconscious facial expression mimicry is preserved in older adulthood. Psychology and Aging, 24, 9951000.CrossRefGoogle ScholarPubMed
Bailey, P.E., Henry, J.D., & Nangle, M.R. (2009). Electromyographic evidence for age-related differences in the mimicry of anger. Psychology and Aging, 24, 224229.CrossRefGoogle ScholarPubMed
Baron-Cohen, S. (2005). The empathizing system: A revision of the 1994 model of the mindreading system. In Ellis, B. & Bjorklund, D. (Eds.), Origins of the social mind (pp. 468492). New York: Guilford Press.Google Scholar
Beall, P.M., Moody, E.J., McIntosh, D.N., Hepburn, S.L., & Reed, C.L. (2008). Rapid facial reactions to emotional facial expressions in typically developing children and children with autism spectrum disorder. Journal of Experimental Child Psychology, 101, 206223.CrossRefGoogle ScholarPubMed
Bertrand, M.C., Achim, A.M., Harvey, P.O., Sutton, H., Malla, A.K., & Lepage, M. (2008). Structural neural correlates of impairments in social cognition in first episode psychosis. Social Neuroscience, 3, 7988.CrossRefGoogle ScholarPubMed
Blair, R.J.R. (2005). Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations. Consciousness and Cognition, 14, 698718.CrossRefGoogle Scholar
Brekke, J.S., Hoe, M., Long, J., & Green, M.F. (2007). How neurocognition and social cognition influence functional change during community based psychosocial rehabilitation for individuals with schizophrenia. Schizophrenia Bulletin, 33, 12471256.CrossRefGoogle ScholarPubMed
Brüne, M. (2005). Emotion recognition, ’theory of mind,’ and social behavior in schizophrenia. Psychiatry Research, 133, 135147.CrossRefGoogle ScholarPubMed
Buccino, G., & Amore, M. (2008). Mirror neurons and the understanding of behavioural symptoms in psychiatric disorders. Current Opinions in Psychiatry, 21, 281285.CrossRefGoogle ScholarPubMed
Carr, L., Iacoboni, M., Dubeau, M.C., Mazziotta, J.C., & Lenzi, G.L. (2003). Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas. Proceedings of the National Academy of Sciences of the United States of America, 100, 54975502.CrossRefGoogle ScholarPubMed
Cattaneo, L., Fabbri-Destro, M., Boria, S., Pieraccini, C., Monti, A., Cossu, G., et al. . (2007). Impairment of actions chains in autism and its possible role in intention understanding. Proceedings of the National Academy of Sciences of the United States of America, 104, 1782517830.CrossRefGoogle ScholarPubMed
Dapretto, M., Davies, M.S., Pfeifer, J.H., Scott, A.A., Sigman, M., Bookheimer, S.Y., et al. . (2006). Understanding emotions in others: Mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience, 9, 2830.CrossRefGoogle ScholarPubMed
Decety, J., Chaminade, T., Grezes, J., & Meltzoff, A.N. (2002). A PET exploration of the neural mechanisms involved in reciprocal imitation. Neuroimage, 15, 265272.CrossRefGoogle ScholarPubMed
Decety, J., & Jackson, P.L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3, 71100.CrossRefGoogle ScholarPubMed
Decety, J., & Meyer, M. (2008). From emotion resonance to empathic understanding: A social developmental neuroscience account. Development and Psychopathology, 20, 10531080.CrossRefGoogle ScholarPubMed
Derntl, B., Finkelmeyer, A., Toygar, T.K., Hulsmann, A., Schneider, F., Falkenberg, D.I., et al. . (2009). Generalized deficit in all core components of empathy in schizophrenia. Schizophrenia Research, 108, 197206.CrossRefGoogle ScholarPubMed
Dimberg, U. (1982). Facial reactions to facial expressions. Psychophysiology, 19, 643647.CrossRefGoogle ScholarPubMed
Dimberg, U., Hansson, G., & Thunberg, M. (1998). Fear of snakes and facial reactions: A case of rapid emotional responding. Scandinavian Journal of Psychology, 39, 7580.CrossRefGoogle Scholar
Dimberg, U., & Lundqvist, L.O. (1988). Facial reactions to facial expressions: Sex differences. Psychophysiology, 25, 442443.Google Scholar
Dimberg, U., & Lundqvist, L.O. (1990). Gender differences in facial reactions to facial expressions. Biological Psychology, 30, 151159.CrossRefGoogle ScholarPubMed
Dimberg, U., & Petterson, M. (2000). Facial reactions to happy and angry facial expressions: Evidence for right hemisphere dominance. Psychophysiology, 37, 693696.CrossRefGoogle ScholarPubMed
Dimberg, U., & Thunberg, M. (1998). Rapid facial reactions to emotional facial expressions. Scandinavian Journal of Psychology, 39, 3945.CrossRefGoogle ScholarPubMed
Dimberg, U., Thunberg, M., & Elmehed, K. (2000). Unconscious facial reactions to emotional facial expressions. Psychological Science, 11, 8689.CrossRefGoogle ScholarPubMed
Dimberg, U., Thunberg, M., & Grunedal, S. (2002). Facial reactions to emotional stimuli: Automatically controlled emotional responses. Cognition & Emotion, 16, 449471.CrossRefGoogle Scholar
di Pellegrino, G., Fadiga, L., Fogassi, L., Gallese, V., & Rizzolatti, G. (1992). Understanding motor events: A neuropsychological study. Experimental Brain Research, 91, 176180.CrossRefGoogle Scholar
Edwards, J., Jackson, H.J., & Pattison, P.E. (2002). Emotion recognition via facial expression and affective prosody in schizophrenia: A methodological review. Clinical Psychology Review, 22, 789832.CrossRefGoogle ScholarPubMed
Ekman, P., & Friesen, W.V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press.Google Scholar
Enticott, P.G., Hoy, K.E., Herring, S.E., Johnston, P.J., Daskalakis, Z.J., & Fitzgerald, P.B. (2008). Reduced motor facilitation during action observation in schizophrenia: A mirror neuron deficit? Schizophrenia Research, 102, 116121.CrossRefGoogle ScholarPubMed
Gallese, V. (2001). The “shared manifold” hypothesis. Journal of Consciousness Studies, 8, 3350.Google Scholar
Henry, J.D., Green, M.J., de Lucia, A., Restuccia, C., McDonald, S., & O’Donnell, M. (2007). Emotion dysregulation in schizophrenia: Reduced amplification of emotional expression is associated with emotional blunting. Schizophrenia Research, 95, 197204.CrossRefGoogle ScholarPubMed
Humberstone, V., Wheeler, A., & Lambert, T. (2004). An audit of outpatient antipsychotic usage in the three health sectors of Auckland, New Zealand. Australian and New Zealand Journal of Psychiatry, 38, 240245.CrossRefGoogle ScholarPubMed
Iacoboni, M., & Dapretto, M. (2006). The mirror neuron system and the consequences of its dysfunction. Nature Reviews, 7, 942951.CrossRefGoogle ScholarPubMed
Iacoboni, M., Koski, L., Brass, M., Bekkering, H., Woods, R.P., Dubeau, M.C., et al. . (2001). Reafferent copies of imitated actions in the right superior temporal cortex. Proceedings of the National Academy of Sciences of the United States of America, 98, 1399513999.CrossRefGoogle ScholarPubMed
Iacoboni, M., Woods, R.P., Brass, M., Bekkering, H., Mazziotta, J.C., & Rizzolatti, G. (1999). Cortical mechanisms of human imitation. Science, 286, 25262528.CrossRefGoogle ScholarPubMed
Kring, A.M., Kerr, S.L., & Earnst, K.S. (1999). Schizophrenic patients show facial reactions to emotional facial expressions. Psychophysiology, 36, 186192.CrossRefGoogle ScholarPubMed
Langdon, R., Coltheart, M., & Ward, P. (2006). Empathetic perspective-taking is impaired in schizophrenia: Evidence from a study of emotion attribution and theory of mind. Cognitive Neuropsychiatry, 11, 133155.CrossRefGoogle ScholarPubMed
Leiberg, S., & Anders, S. (2006). The multiple facets of empathy: A survey of theory and evidence. Progress in Brain Research, 156, 419440.CrossRefGoogle ScholarPubMed
Lovibond, S.H., & Lovibond, P.F. (1995). Manual for the Depression Anxiety Stress Scales. (2nd. Ed.). Sydney: Psychology Foundation.Google Scholar
Mattes, R.M., Schneider, F., Heimann, H., & Birbaumer, N. (1995). Reduced emotional response of schizophrenia patients in remission during social interaction. Schizophrenia Research, 17, 249255.CrossRefGoogle ScholarPubMed
McIntosh, D.N., Reichmann-Decker, A., Winkielman, P., & Wilbarger, J.L. (2006). When the social mirror breaks: Deficits in automatic, but not voluntary, mimicry of emotional facial expressions in autism. Developmental Science, 9, 295302.CrossRefGoogle Scholar
Milev, P., Ho, B., Arndt, S., & Andreassen, N.C. (2005). Predictive value of neurocognition and negative symptoms on functional outcome in schizophrenia: A longitudinal first episode study with 7 years follow-up. American Journal of Psychiatry, 162, 495506.CrossRefGoogle Scholar
Moody, E.J., & McIntosh, D.N. (2006). Mimicry and autism: Bases and consequences of rapid, automatic matching behavior. In Rogers, S. & Williams, J. (Eds.), Imitation and the social mind: Autism and typical development (pp. 7195). New York: Guilford Press.Google Scholar
Moody, E.J., McIntosh, D.N., Mann, L.J., & Weisser, K.R. (2007). More than mere mimicry? The influence of emotion on rapid facial reactions to faces. Emotion, 7, 447457.CrossRefGoogle ScholarPubMed
Mueser, K.T., & Bellack, A.S. (1998). Social skills and social functioning. In Mueser, K.T. & Tarrier, N. (Eds.), Handbook of social functioning in schizophrenia (pp. 7996). Boston: Allyn and Bacon.Google Scholar
Nelson, H.E., & Willison, J. (1991). National adult reading test manual (2nd ed.). Windsor, UK: NFER-Nelson.Google Scholar
Niedenthal, P.M., Barsalou, L.W., Winkielman, P., Krauth-Gruber, S., & Ric, F. (2005). Embodiment in attitudes, social perception, and emotion. Personality and Social Psychology Review, 9, 184211.CrossRefGoogle ScholarPubMed
Oberman, L.M., & Ramachandran, V.S. (2007). The simulating social mind: The role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders. Psychological Bulletin, 133, 310327.CrossRefGoogle ScholarPubMed
Oberman, L.M., Winkielman, P., & Ramachandran, V.S. (2009). Slow echo: Facial EMG evidence for the delay of spontaneous, but not voluntary, emotional mimicry in children with autism spectrum disorders. Developmental Science, 12, 510520.CrossRefGoogle Scholar
Park, S., Matthews, N., & Gibson, C. (2008). Imitation, simulation, and schizophrenia. Schizophrenia Bulletin, 34, 698707.CrossRefGoogle ScholarPubMed
Pijnenborg, G.H.M., Withaar, F.K., Evans, J.J., van den Bosch, R.J., Timmerman, M.E., & Brouwer, W.H. (2009). The predictive value of measures of social cognition for community functioning in schizophrenia: Implications for neuropsychological assessment. Journal of the International Neuropsychological Society, 15, 239247.CrossRefGoogle ScholarPubMed
Pinkham, A.E., Hopfinger, J.B., Pelphrey, K.A., Piven, J., & Penn, D.L. (2008). Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders. Schizophrenia Research, 99, 164175.CrossRefGoogle ScholarPubMed
Preston, S.D., & de Waal, F.B.M. (2002). Empathy: Its ultimate and proximate bases. Behavioral and Brain Sciences, 25, 172.CrossRefGoogle ScholarPubMed
Rizzolatti, G., & Craighero, L. (2004). The mirror-neuron system. Annual Review of Neuroscience, 27, 169192.CrossRefGoogle ScholarPubMed
Shamay-Tsoory, S.G., Shur, S., Harari, H., & Levkovitz, Y. (2007). Neurocognitive basis of impaired empathy in schizophrenia. Neuropsychology, 21, 431438.CrossRefGoogle ScholarPubMed
Singer, T., & Lamm, C. (2009). The social neuroscience of empathy. Annals of the New York Academy of Sciences, 1156, 8196.CrossRefGoogle ScholarPubMed
Sonnby-Borgstrom, M., Jonsoon, P., & Svensson, O. (2003). Emotional empathy as related to mimicry reactions at different levels of information processing. Journal of Nonverbal Behavior, 27, 323.CrossRefGoogle Scholar
Tassinary, L.G., & Cacioppo, J.T. (2000). The skelemotor system: Surface electromyography. In Cacioppo, J.T., Tassinary, L.G. & Bernston, G.G. (Eds.), Handbook of Psychophysiology (2nd ed., pp. 163199). Cambridge: Cambridge University Press.Google Scholar
Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: The Psychological Corporation.Google Scholar
Williams, J.H.G., Whiten, A., Suddendorf, T., & Perrett, D.I. (2001). Imitation, mirror neurons and autism. Neuroscience & Biobehavioral Reviews, 25, 287295.CrossRefGoogle ScholarPubMed
Wolf, K., Mass, R., Kiefer, F., Eckert, K., Weinhold, N., Wiedemann, K., et al. . (2004). The influence of olanzapine on facial expression of emotions in schizophrenia: An improved facial EMG study. German Journal of Psychiatry, 7, 1419.Google Scholar
Wolf, K., Mass, R., Kiefer, F., Wiedemann, K., & Naber, D. (2006). Characterization of the facial expression of emotions in schizophrenia patients: Preliminary findings with a new electromyography method. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 51, 335341.CrossRefGoogle ScholarPubMed