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The effects of treatment for posterior fossa brain tumors on selective attention

Published online by Cambridge University Press:  01 March 2009

DONALD J. MABBOTT ,
JANICE J. SNYDER ,
LOUISE PENKMAN  and
ADRIENNE WITOL
DONALD J. MABBOTT*
Affiliation:
Department of Psychology, Hospital for Sick Children/University of Toronto, Toronto, Ontario, Canada
JANICE J. SNYDER
Affiliation:
Department of Psychology, University of British Columbia, Okanagan, Kelowna, British Columbia, Canada
LOUISE PENKMAN
Affiliation:
Southern Alberta Children’s Cancer Program, Alberta Children’s Hospital, Calgary, Alberta, Canada
ADRIENNE WITOL
Affiliation:
Northern Alberta Children’s Cancer Program, Stollery Children’s Hospital/University of Alberta, Edmonton, Alberta, Canada
*
*Correspondence and reprint requests to: Donald Mabbott, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada. E-mail: [email protected]
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Abstract

We sought to identify whether deficits in selective attention are present in pediatric brain tumor patients. Selective attention was assessed with covert-orienting, filtering, and visual-search tasks in 54 patients with either (1) posterior fossa (PF) tumors treated with cranial radiation and surgery (n = 22); (2) PF tumors treated with surgery alone (n = 17); or (3) non-CNS tumors (n = 15), who served as a patient control group. To account for normal development, patient performance was also compared with that of healthy age-matched controls (n = 10). We found that in PF tumor patients selective attention was impaired, regardless of whether they were treated with cranial radiation and surgery or surgery alone. However, patients treated with cranial radiation were most impaired. These patients may have greater damage to posterior brain regions know to mediate selective attention as the result of tumor location, effects of surgery, and higher doses of radiation to the posterior regions of the brain. These findings help to elucidate the potential impact of pediatric brain tumors and their treatment on discrete attentional skills. (JINS, 2009, 15, 205–216.)

Keywords

Brain neoplasmCognition disordersChild psychologyPosterior cranial fossaRadiotherapySurgery
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 2 , March 2009 , pp. 205 - 216
Copyright
Copyright © INS 2009

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References

REFERENCES

Akhtar, N. & Enns, J.T. (1989). Relations between covert orienting and filtering in the development of visual attention. Journal of Experimental Child Psychology, 48, 315–334.CrossRefGoogle ScholarPubMed
Booth, J.R., Burman, D.D., Meyer, J.R., Lei, Z., Trommer, B.L., Davenport, N.D., Li, W., Parrish, T.B., Gitelman, D.R., & Mesulam, M.M. (2003). Neural development of selective attention and response inhibition. Neuroimage, 20, 737–751.CrossRefGoogle ScholarPubMed
Booth, J.R., Burman, D.D., Meyer, J.R., Trommer, B.L., Davenport, N.D., Parrish, T.B., Gitelman, D.R., & Mesulam, M.M. (2004). Brain-behavior correlation in children depends on the neurocognitive network. Human Brain Mapping, 23, 99–108.CrossRefGoogle ScholarPubMed
Butler, R.W. & Copeland, D.R. (2002). Attentional processes and their remediation in children treated for cancer: A literature review and the development of a therapeutic approach. Journal of the International Neuropsychological Society, 8, 115–124.Google Scholar
Butler, R.W. & Mulhern, R.K. (2005). Neurocognitive interventions for children and adolescents surviving cancer. Journal of Pediatric Psychology, 30, 65–78.Google Scholar
Carlson-Green, B., Morris, R.D., & Krawiecki, N. (1995). Family and illness predictors of outcome in pediatric brain tumors. Journal of Pediatric Psychology, 20, 769–784.Google Scholar
Corbetta, M., Miezin, F.M., Shulman, G.L., & Petersen, S.E. (1993). A pet study of visuospatial attention. Journal of Neuroscience, 13, 1202–1226.Google Scholar
Davies, D.R. & Parasuraman, R. (1982). The psychology of vigilance. London: Academic Press.Google Scholar
Dennis, M., Hetherington, C.R., & Spiegler, B.J. (1998). Memory and attention after childhood brain tumors. Medical Pediatric Oncology, Suppl 1, 25–33.Google Scholar
Dennis, M., Edelstein, K., Hetherington, R., Copeland, K., Frederick, J., Blaser, S.E., Kramer, L.A., Drake, J.M., Brandt, M., & Fletcher, J.M. (2004). Neurobiology of perceptual and motor timing in children with spina bifida in relation to cerebellar volume. Brain, 127, 1292–1301.Google Scholar
Dennis, M., Landry, S.H., Barnes, M., & Fletcher, J.M. (2006). A model of neurocognitive function in spina bifida over the life span. Journal of the International Neuropsychological Society, 12, 285–296.CrossRefGoogle Scholar
Dum, R.P. & Strick, P.L. (2003). An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex. Journal of Neurophysiology, 89, 634–639.Google Scholar
Enns, J.T. & Akhtar, N. (1989). A developmental study of filtering in visual attention. Child Development, 60, 1188–1199.CrossRefGoogle ScholarPubMed
Enns, J.T. & Brodeur, D.A. (1989). A developmental study of covert orienting to peripheral visual cues. Journal of Experimental Child Psychology, 48, 171–189.Google Scholar
Eriksen, B.A. & Eriksen, C.W. (1974). Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception 6 – Psychophysics, 16, 143–149.Google Scholar
Fan, J., McCandliss, B.D., Sommer, T., Raz, A., & Posner, M.I. (2002). Testing the efficiency and independence of attentional networks. Journal of Cognitive Neuroscience, 14(3), 340–347.Google Scholar
Habrand, J.L. & De Crevoisier, R. (2001). Radiation therapy in the management of childhood brain tumors. Child’s Nervous System, 17(3), 121–133.Google Scholar
Johnson, D.L., McCabe, M.A., Nicholson, H.S., Joseph, A.L., Getson, P.R., Byrne, J., Brasseux, C., Packer, R.J., & Reaman, G. (1994). Quality of long-term survival in young children with medulloblastoma. Journal of Neurosurgery, 80, 1004–1010.Google Scholar
Jonides, J. (1981). Voluntary versus automatic control over the mind’s eye movement. In Long, J. & Baddley, A. (Eds.), Attention and performance IX (pp. 187–203). Hillsdale, NJ: Erlbaum.Google Scholar
Mabbott, D.J., Noseworthy, M.D., Bouffet, E., Rockel, C., & Laughlin, S. (2006). Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: Correlation with IQ. Neuro-oncology, 8, 244–252.CrossRefGoogle ScholarPubMed
Mabbott, D.J., Penkman, L., Witol, A., Strother, D., & Bouffet, E. (2008). Attention, processing speed, and working memory in children treated for posterior fossa tumours, Neuropsychology, 22, 159–168.CrossRefGoogle Scholar
Mabbott, D.J., Spiegler, B., Greenberg, M., Rutka, J., Hyder, D., & Bouffet, E. (2005). Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. Journal of Clinical Oncology, 23, 2256–2263.CrossRefGoogle ScholarPubMed
Merchant, T.E., Kiehna, E.N., Miles, M.A., Zhu, J., Xiong, X., & Mulhern, R.K. (2002). Acute effects of irradiation on cognition: Changes in attention on a computerized continuous performance test during radiotherapy in pediatric patients with localized primary brain tumors. International Journal of Radiation Oncology, Biology and Physics, 53, 1271–1278.Google Scholar
Mulhern, R.K., Palmer, S.L., Merchant, T.E., Wallace, D., Kocak, M., Brouwers, P., Krull, K., Chintagumpala, M., Stargatt, R., Ashley, D.M., Tyc, V.L., Kun, L., Boyett, J., & Gajjar, A. (2005). Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. Journal of Clinical Oncology, 23, 5511–5519.Google Scholar
Mulhern, R.K., Khan, R.B., Kaplan, S., Helton, S., Christensen, R., Bonner, M., Brown, R., Xiong, X., Wu, S., Gururangan, S., & Reddick, W.E. (2004a). Short-term efficacy of methylphenidate: A randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. Journal of Clinical Oncology, 22, 4795–4803.CrossRefGoogle ScholarPubMed
Mulhern, R.K., White, H.A., Glass, J.O., Kun, L.E., Leigh, L., Thompson, S.J., & Reddick, W.E. (2004b). Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood. Journal of the International Neuropsychological Society, 10, 180–189.Google Scholar
Müller, H.J. & Rabbitt, P.M.A. (1989). Reflexive and voluntary orienting of visual attention: Time course of activation and resistance to interruption. Journal of Experimental Psychology: Human Perception and Performance, 15, 315–330.Google Scholar
Nagel, B.J., Palmer, S.L., Reddick, W.E., Glass, J.O., Helton, K.J, Wu, S., Xiong, X., Kun, L.E., Gajjar, A., & Mulhern, R.K. (2004). Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation. American Journal of Neuroradiology, 25, 1575–1582.Google ScholarPubMed
Packer, R.J., Goldwein, J., Nicholson, H.S., Vezina, L.G., Allen, J.C., Ris, MD., Muraszko, K., Rorke, L.B., Wara, W.M., Cohen, B.H., & Boyett, J.M. (1999). Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A children’s cancer group study. Journal of Clinical Oncology, 17, 2127–2136.Google Scholar
Palmer, S.L., Gajjar, A., Reddick, W.E., Glass, J.O., Kun, L.E., Wu, S., Xiong, X., & Mulhern, R.K. (2003). Predicting intellectual outcome among children treated with 35–40 gy craniospinal irradiation for medulloblastoma. Neuropsychology, 17, 548–555.Google Scholar
Pashler, H. (1988). The psychology of attention. Cambridge, MA: MIT Press.Google Scholar
Plude, D.J., Enns, J.T., & Brodeur, D. (1994). The development of selective attention: A life-span overview. Acta Psychologica (Amsterdam), 86(2-3), 227–272.CrossRefGoogle ScholarPubMed
Penkman, L. (2004). Remediation of attention deficits in children: A focus on childhood cancer, traumatic brain injury and attention deficit disorder. Pediatric Rehabilitation, 7, 111–123.Google Scholar
Posner, M.I. (1980). Orienting of attention. Quarterly Journal of Experimental Psychology, 32, 3–25.CrossRefGoogle ScholarPubMed
Radcliffe, J., Bennett, D., Kazak, A.E., Foley, B., & Phillips, P.C. (1996) Adjustment in childhood brain tumor survival: Child, mother, and teacher report. Journal of Pediatric Psychology, 21, 529–539.Google Scholar
Reddick, W.E., White, H.A., Glass, J.O., Wheeler, G.C., Thompson, S.J., Gajjar, A., Leigh, L., & Mulhern, R.K. (2003). Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer, 97, 2512–2519.CrossRefGoogle ScholarPubMed
Ris, M.D., Packer, R., Goldwein, J., Jones-Wallace, D., & Boyett, J.M. (2001). Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: A children’s cancer group study. Journal of Clinical Oncology, 19, 3470–3476.Google Scholar
Rueda, M.R., Fan, J., McCandliss, B.D., Halparin, J.D., Gruber, D.B., Lercari, L.P., & Posner, M. (2004). Development of attentional networks in childhood. Neuropsychologia, 42, 1029–1040.Google Scholar
Sarter, M., Givens, B., & Bruno, J.P. (2001). The cognitive neuroscience of sustained attention: Where top-down meets bottom-up. Brain Research & Brain Research Reviews, 35(2), 146–160.Google Scholar
Sattler, J. (2001). Assessment of Children: Cognitive Applications (4th ed.). La Mesa, CA: Jerome Sattler.Google Scholar
Schatz, J., Kramer, J.H., Ablin, A., & Matthay, K.K. (2000). Processing speed, working memory, and IQ: A developmental model of cognitive deficits following cranial radiation therapy. Neuropsychology, 14, 189–200.CrossRefGoogle ScholarPubMed
Schmahmann, J.D. & Pandya, D.N. (1997). The cerebrocerebellar system. International Review of Neurobiology, 41, 31–60.Google Scholar
Seaver, E., Geyer, R., Sulzbacher, S., Warner, M., Batzel, L., Milstein, J., & Berger, M. (1994). Psychosocial adjustment in long-term survivors of childhood medulloblastoma and ependymoma treated with craniospinal irradiation. Pediatric Neurosurgery, 20, 248–253.CrossRefGoogle ScholarPubMed
Smith, M.A. & Gloeckler Reis, L.A. (2002). Childhood Cancer: Incidence, survival, and mortality (Fourth Edition (ed.). Philidelphia, PA:Lippincott, Williams, & Wilkins.Google Scholar
Spiegler, B.J., Bouffet, E., Greenberg, M.L., Rutka, J.T., & Mabbott, D.J. (2004). Change in neurocognitive functioning after treatment with cranial radiation in childhood. Journal of Clinical Oncology, 22, 706–713.Google Scholar
Strother, D.R., Pollack, I.F., Fisher, P.G., Hunter, J.V., Woo, S.Y., Pomeroy, S.L., & Rorke, L.B. (2002). Tumors of the central nervous system In Pizzo, P.A. & Poplack, D.G. (Eds.), Principles and practice of pediatric oncology, (4th ed.) (pp. 751–825). Philadelphia: Lippincott, Williams, & Wilkins.Google Scholar
Thompson, S.J., Leigh, L., Christensen, R., Xiong, X., Kun, L.E., Heideman, R.L., Reddick, W.E., Gajjar, A., Merchant, T., Pui, C.H., Hudson, M.M., & Mulhern, R.K. (2001). Immediate neurocognitive effects of methylphenidate on learning-impaired survivors of childhood cancer. Journal of Clinical Oncology, 19, 1802–1808.CrossRefGoogle ScholarPubMed
Trick, L.M. & Enns, J.T. (1998). Lifespan changes in attention: The visual search task. Cognitive Development, 13, 369–386.Google Scholar
Treisman, A. & Gelade, G. (1980). A feature-integration theory of attention. Cognitive Psychology, 12, 97–136.Google Scholar
Warm, J.S. (1984). An introduction to vigilance. In Warm, J.S. (Ed.), Sustained attention in human performance (pp. 1–14). Chichester, UK: Wiley.Google Scholar
Yantis, S. & Jonides, J. (1990). Abrupt visual onsets and selective attention: Voluntary versus automatic allocation. Journal of Experimental Psychology: Human Perception and Performance, 16, 121–134.Google Scholar
Zucchinelli, V. & Bouffet, E. (2000). Academic future of children treated for brain tumors. Single-center study of 27 children. Archives de pédiatrie, 7, 933–941.CrossRefGoogle ScholarPubMed