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Different cognitive profiles between mild cognitive impairment due to cerebral small vessel disease and mild cognitive impairment of Alzheimer’s disease origin

Published online by Cambridge University Press:  01 November 2009

AIHONG ZHOU  and
JIANPING JIA
AIHONG ZHOU
Affiliation:
Department of Neurology, Xuan Wu Hospital, Capital Medical University, Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China
JIANPING JIA*
Affiliation:
Department of Neurology, Xuan Wu Hospital, Capital Medical University, Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China
*
*Correspondence and reprint requests to: Jianping Jia, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China. E-mail: [email protected]
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Abstract

Controversy surrounds the differences of the cognitive profile between mild cognitive impairment resulting from cerebral small vessel disease (MCI-SVD) and mild cognitive impairment associated with prodromal Alzheimer’s disease (MCI-AD). The aim of this study was to explore and compare the cognitive features of MCI-SVD and MCI-AD. MCI-SVD patients (n = 56), MCI-AD patients (n = 30), and normal control subjects (n = 80) were comprehensively evaluated with neuropsychological tests covering five cognitive domains. The performance was compared between groups. Tests that discriminated between MCI-SVD and MCI-AD were identified. Multiple cognitive domains were impaired in MCI-SVD group, while memory and executive function were mainly impaired in MCI-AD group. Compared with MCI-SVD, MCI-AD patients performed relatively worse on memory tasks, but better on processing speed measures. The AVLT Long Delay Free Recall, Digit Symbol Test, and Stroop Test Part A (performance time) in combination categorized 91.1% of MCI-SVD patients and 86.7% of MCI-AD patients correctly. Current study suggested a nonspecific neuropsychological profile for MCI-SVD and a more specific cognitive pattern in MCI-AD. MCI-AD patients demonstrated greater memory impairment with relatively preserved mental processing speed compared with MCI-SVD patients. Tests tapping these two domains might be potentially useful for differentiating MCI-SVD and MCI-AD patients. (JINS, 2009, 15, 898–905.)

Keywords

Mild cognitive impairmentCerebral small vessel diseaseAlzheimer’s diseaseCognitive profileVascular dementiaLeukoaraiosis
Type
MCI Series
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 6 , November 2009 , pp. 898 - 905
Copyright
Copyright © The International Neuropsychological Society 2009

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References

REFERENCES

Alzheimer’s Disease Cooperative Study Group. (1999). A randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of vitamin E and donepezil HCL (Aricept) to delay clinical progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Protocol no. ADC-008.Google Scholar
American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed). Washington, DC: American Psychiatric Association.Google Scholar
Bäckman, L., Jones, S., Berger, A.K., Laukka, E.J., & Small, B.J. (2005). Cognitive impairment in preclinical Alzheimer’s disease: A meta-analysis. Neuropsychology, 19, 520–531.CrossRefGoogle ScholarPubMed
Blake, H., McKinney, M., Treece, K., Lee, E., & Lincoln, N.B. (2002). An evaluation of screening measures for cognitive impairment after stroke. Age and Ageing, 31, 451–456.CrossRefGoogle ScholarPubMed
Chui, H. (2001). Dementia due to subcortical ischaemic vascular disease. Clinical Cornerstone, 3, 40–51.CrossRefGoogle Scholar
Dai, X.Y., Ryan, J.J., Paolo, A.M., & Harrington, R.G. (1990). Factor analysis of the mainland Chinese version of the Wechsler Adult Intelligence Scale (WAIS-RC) in a brain-damaged sample. The International Journal of Neuroscience, 55, 107–111.CrossRefGoogle Scholar
Delis, D.C., Kaplan, E., & Kramer, J.H. (2000). The Delis-Kaplan executive function scale. San Antonio, TX: The Psychological Corporation.Google Scholar
Elderkin-Thompson, V., Kumar, A., Mintz, J., Boone, K., Bahng, E., & Lavretsky, H. (2004). Executive dysfunction and visuospatial ability among depressed elders in a community setting. Archives of Clinical Neuropsychology, 19, 597–611.CrossRefGoogle Scholar
Flicker, C., Ferris, S.H., & Reisberg, B. (1991). Mild cognitive impairment in the elderly: Predictors of dementia. Neurology, 41, 1006–1009.CrossRefGoogle ScholarPubMed
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle ScholarPubMed
Frisoni, G.B., Galluzzi, S., Bresciani, L., Zanetti, O., & Geroldi, C. (2002). Mild cognitive impairment with subcortical vascular features: Clinical characteristics and outcome. Journal of Neurology, 249, 1423–1432.CrossRefGoogle ScholarPubMed
Gainotti, G., Ferraccioli, M., Vita, M.G., & Marra, C. (2008). Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy. Journal of the International Neuropsychological Society, 14, 611–619.CrossRefGoogle ScholarPubMed
Garrett, K.D., Browndyke, J.N., Whelihan, W., Paul, R.H., DiCarlo, M., Moser, D.J., et al. (2004). The neuropsychological profile of vascular cognitive impairment-no dementia: Comparisons to patients at risk for cerebrovascular disease and vascular dementia. Archives of Clinical Neuropsychology, 19, 745–757.CrossRefGoogle ScholarPubMed
Graham, N.L., Emery, T., & Hodges, J.R. (2004). Distinctive cognitive profiles in Alzheimer’s disease and subcortical vascular dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 75, 61–71.Google ScholarPubMed
Ingles, J.L., Wentzel, C., Fisk, J.D., & Rockwood, K. (2002). Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, without dementia. Stroke, 33, 1999–2002.CrossRefGoogle ScholarPubMed
Jokinen, H., Kalska, H., Mantyla, R., Ylikoski, R., Hietanen, M., Pohjasvaara, T., et al. (2005). White matter hyperintensities as a predictor of neuropsychological deficits post-stroke. Journal of Neurology, Neurosurgery, and Psychiatry, 76, 1229–1233.CrossRefGoogle ScholarPubMed
Kramer, J.H., Reed, B.R., Mungas, D., Weiner, M.W., & Chui, H.C. (2002). Executive dysfunction in subcortical ischaemic vascular disease. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 217–220.CrossRefGoogle ScholarPubMed
Lezak, M.D. (1995). Neuropsychological Assessment (3rd ed). New York: Oxford University Press.Google Scholar
Loewenstein, D.A., Acevedo, A., Agron, J., Issacson, R., Strauman, S., Crocco, E., et al. (2006). Cognitive profiles in Alzheimer’s disease and in mild cognitive impairment of different etiologies. Dementia and Geriatric Cognitive Disorders, 21, 309–315.CrossRefGoogle ScholarPubMed
Lopez, O.L., Kuller, L.H., Becker, J.T., Dulberg, C., Sweet, R.A., Gach, H.M., et al. (2007). Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. Archives of Neurology, 64, 416–420.CrossRefGoogle ScholarPubMed
Maj, M., Satz, P., Janssen, R., Zaudig, M., Starace, F., D’Elia, L., et al. (1994). WHO Neuropsychiatric AIDS study, cross-sectional phase II. Neuropsychological and neurological findings. Archives of General Psychiatry, 51, 51–61.CrossRefGoogle ScholarPubMed
Meyer, J.S., Xu, G., Thornby, J., Chowdhury, M.H., & Quach, M. (2002). Is mild cognitive impairment prodromal for vascular dementia like Alzheimer’s disease? Stroke, 33, 1981–1985.CrossRefGoogle ScholarPubMed
Mori, E. (2002). Impact of subcortical ischemic lesions on behavior and cognition. Annals of the New York Academy of Sciences, 977, 141–148.CrossRefGoogle ScholarPubMed
Morris, J.C., Storandt, M., Miller, J.P., McKeel, D.W., Price, J.L., Rubin, E.H., et al. (2001). Mild cognitive impairment represents early-stage Alzheimer disease. Archives of Neurology, 58, 397–405.CrossRefGoogle ScholarPubMed
Osterrieth, P.A. (1994). Le test de copie d’ une figure complex: Contribution a l’ etude de la perception et de la memoire. Archives de Psychologie, 30, 286–356.Google Scholar
Peters, N., Opherk, C., Danek, A., Ballard, C., Herzog, J., & Dichgans, M. (2005). The pattern of cognitive performance in CADASIL: A monogenic condition leading to subcortical ischemic vascular dementia. The American Journal of Psychiatry, 162, 2078–2085.CrossRefGoogle ScholarPubMed
Petersen, R.C., & Morris, J.C. (2005). Mild cognitive impairment as a clinical entity and treatment target. Archives of Neurology, 62, 1160–1163.CrossRefGoogle ScholarPubMed
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., & Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56, 303–308.CrossRefGoogle ScholarPubMed
Petersen, R.C., Thomas, R.G., Grundman, M., Bennett, D., Doody, R., Ferris, S., et al. (2005). Vitamin E and donepezil for the treatment of mild cognitive impairment. The New England Journal of Medicine, 352, 2379–2388.CrossRefGoogle ScholarPubMed
Prins, N.D., van Dijk, E.J., den Heijer, T., Vermeer, S.E., Jolles, J., Koudstaal, P.J., et al. (2005). Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain, 128, 2034–2041.CrossRefGoogle ScholarPubMed
Qiu, W.Q., Price, L.L., Hibberd, P., Buell, J., Collins, L., Leins, D., et al. (2006). Executive dysfunction in homebound older people with diabetes mellitus. Journal of the American Geriatrics Society, 54, 496–501.CrossRefGoogle ScholarPubMed
Reed, B.R., Eberling, J.L., Mungas, D., Weiner, M., Kramer, J.H., & Jagust, W.J. (2004). Effects of white matter lesions and lacunes on cortical function. Archives of Neurology, 61, 1545–1550.CrossRefGoogle ScholarPubMed
Reed, B.R., Mungas, D.M., Kramer, J.H., Ellis, W., Vinters, H.V., Zarow, C., et al. (2007). Profiles of neuropsychological impairment in autopsy-defined Alzheimer’s disease and cerebrovascular disease. Brain, 130, 731–739.CrossRefGoogle ScholarPubMed
Ribeiro, F., de Mendonca, A., & Guerreiro, M. (2006). Mild cognitive impairment: Deficits in cognitive domains other than memory. Dementia and Geriatric Cognitive Disorders, 21, 284–290.CrossRefGoogle ScholarPubMed
Rivas-Vazquez, R.A., Mendez, C., Rey, G.J., & Carrazana, E.J. (2004). Mild cognitive impairment: New neuropsychological and pharmacological target. Archives of Clinical Neuropsychology, 19, 11–27.CrossRefGoogle ScholarPubMed
Román, G.C., Erkinjuntti, T., Wallin, A., Pantoni, L., & Chui, H.C. (2002). Subcortical ischaemic vascular dementia. Lancet Neurology, 1, 426–436.CrossRefGoogle ScholarPubMed
Shulman, K.I. (2000). Clock-drawing: Is it the ideal cognitive screening test? International Journal of Geriatric Psychiatry, 15, 548–561.3.0.CO;2-U>CrossRefGoogle ScholarPubMed
The Cooperation Group for the Construction of “the Clinical Memory Test”. (1986). The construction of “The Clinical Memory Test”. Acta Psychologica Sinica, 18, 100–108.Google Scholar
van der Flier, W.M., van Straaten, E.C., Barkhof, F., Verdelho, A., Madureira, S., Pantoni, L., et al. (2005). Small vessel disease and general cognitive function in nondisabled elderly: The LADIS study. Stroke, 36, 2116–2120.CrossRefGoogle ScholarPubMed
Wahlund, L.O., Barkhof, F., Fazekas, F., Bronge, L., Augustin, M., Sjogren, M., et al. ; European Task Force on Age-Related White Matter Changes. (2001). A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke, 32, 1318–1322.CrossRefGoogle ScholarPubMed
Watanabe, K., Ogino, T., Nakano, K., Hattori, J., Kado, Y., Sanada, S., et al. (2005). The Rey-Osterrieth Complex Figure as a measure of executive function in childhood. Brain & Development, 27, 564–569.CrossRefGoogle ScholarPubMed
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L.O., et al. (2004). Mild cognitive impairment–beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240–246.CrossRefGoogle Scholar