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Differences in olfactory and visual memory in patients with pathologically confirmed Alzheimer's disease and the Lewy body variant of Alzheimer's disease

Published online by Cambridge University Press:  01 October 2004

PAUL E. GILBERT ,
P. JOYCE BARR  and
CLAIRE MURPHY
PAUL E. GILBERT
Affiliation:
Department of Head and Neck Surgery, University of California San Diego, San Diego, California
P. JOYCE BARR
Affiliation:
Graduate School of Public Health, San Diego State University, San Diego, California
CLAIRE MURPHY
Affiliation:
Department of Head and Neck Surgery, University of California San Diego, San Diego, California San Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, California
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Abstract

Recognition and remote memory for odors, faces, and symbols were assessed in patients with pathologically confirmed Lewy body variant of Alzheimer's disease (LBV), patients with pathologically confirmed Alzheimer's disease (AD), and healthy elderly controls. On recognition memory tasks, LBV and AD patients showed significantly lower discriminability (d′) than controls, particularly for olfactory stimuli. However no significant differences were found in the bias measure (c). When participants rated familiarity (a proposed measure of remote memory) of olfactory stimuli LBV and AD patients reported significantly lower familiarity than controls. Familiarity ratings were significantly lower in LBV patients than in AD patients for olfactory, but not for visual stimuli. Consistent with prior reports, the LBV patients showed significantly poorer odor thresholds than AD patients. The results suggest that recognition memory for olfactory stimuli is impaired in LBV and AD. However, patients with LBV are more impaired than patients with AD on tasks requiring remote memory for olfactory but not visual stimuli. The findings suggest that odor memory tasks may be useful in the assessment of LBV and AD. (JINS, 2004, 10, 835–842.)

Keywords

Recognition memoryRemote memoryOlfactionOdorSmellAlzheimer's diseaseLewy body variant
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 6 , October 2004 , pp. 835 - 842
Copyright
© 2004 The International Neuropsychological Society

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