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Decreased White Matter Integrity in Neuropsychologically Defined Mild Cognitive Impairment Is Independent of Cortical Thinning

Published online by Cambridge University Press:  01 July 2013

Nikki H. Stricker ,
David H. Salat ,
Jessica M. Foley ,
Tyler A. Zink ,
Ida L. Kellison ,
Craig P. McFarland ,
Laura J. Grande ,
Regina E. McGlinchey ,
William P. Milberg  and
Elizabeth C. Leritz
Nikki H. Stricker*
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts
David H. Salat
Affiliation:
Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Massachusetts Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
Jessica M. Foley
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
Tyler A. Zink
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts
Ida L. Kellison
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts
Craig P. McFarland
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts
Laura J. Grande
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts
Regina E. McGlinchey
Affiliation:
Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
William P. Milberg
Affiliation:
Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
Elizabeth C. Leritz
Affiliation:
Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Massachusetts Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Division of Aging, Brigham & Women's Hospital, Boston, Massachusetts
*
Correspondence and reprint requests to: Nikki H. Stricker, VA Boston Medical Center (116B), 150 S. Huntington Avenue, Jamaica Plain, MA 02130. E-mail: [email protected]
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Abstract

Improved understanding of the pattern of white matter changes in early and prodromal Alzheimer's disease (AD) states such as mild cognitive impairment (MCI) is necessary to support earlier preclinical detection of AD, and debate remains whether white matter changes in MCI are secondary to gray matter changes. We applied neuropsychologically based MCI criteria to a sample of normally aging older adults; 32 participants met criteria for MCI and 81 participants were classified as normal control (NC) subjects. Whole-head high resolution T1 and diffusion tensor imaging scans were completed. Tract-Based Spatial Statistics was applied and a priori selected regions of interest were extracted. Hippocampal volume and cortical thickness averaged across regions with known vulnerability to AD were derived. Controlling for cortical thickness, the MCI group showed decreased average fractional anisotropy (FA) and decreased FA in parietal white matter and in white matter underlying the entorhinal and posterior cingulate cortices relative to the NC group. Statistically controlling for cortical thickness, medial temporal FA was related to memory and parietal FA was related to executive functioning. These results provide further support for the potential role of white matter integrity as an early biomarker for individuals at risk for AD and highlight that changes in white matter may be independent of gray matter changes. (JINS, 2013, 19, 1–13)

Keywords

Diffusion tensor imagingAgingNeuropsychological testsMagnetic resonance imagingMemoryExecutive function
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 8 , September 2013 , pp. 925 - 937
Copyright
Copyright © The International Neuropsychological Society 2013 

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