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A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease

Published online by Cambridge University Press:  01 September 2004

JOANNE M. HAMILTON ,
DAVID P. SALMON ,
DOUGLAS GALASKO ,
DEAN C. DELIS ,
LAWRENCE A. HANSEN ,
ELIEZER MASLIAH ,
RONALD G. THOMAS  and
LEON J. THAL
JOANNE M. HAMILTON
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California
DAVID P. SALMON
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California
DOUGLAS GALASKO
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Neurology Service, Veterans Affairs San Diego Healthcare System, La Jolla, California
DEAN C. DELIS
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California Psychology Service, Veterans Affairs San Diego Healthcare System, La Jolla, California
LAWRENCE A. HANSEN
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Department of Pathology, University of California, San Diego, La Jolla, California
ELIEZER MASLIAH
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Department of Pathology, University of California, San Diego, La Jolla, California
RONALD G. THOMAS
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California
LEON J. THAL
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, California Neurology Service, Veterans Affairs San Diego Healthcare System, La Jolla, California
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Abstract

Little is known about possible differences in the memory deficits that occur in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We compared 24 autopsy-confirmed DLB and 24 age-, education-, and MMSE-matched autopsy-confirmed AD patients on the California Verbal Learning Test (CVLT) and the Wechsler Memory Scale-Revised Logical Memory subtest. The DLB and AD groups were similarly impaired on CVLT Total Learning (Trials 1–5) and Long Delayed Free Recall, but the DLB group demonstrated relative improvement in Savings scores and on recognition testing compared to the AD group. Likewise, the patient groups were equally impaired on Logical Memory immediate and delayed recall, but the DLB group's Saving scores were significantly better than those of the AD patients. These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients. (JINS, 2004, 10, 689–697.)

Keywords

Dementia with Lewy bodiesAlzheimer's diseaseMemory
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 5 , September 2004 , pp. 689 - 697
Copyright
2004 The International Neuropsychological Society

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