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Cannabis Use and Brain Volume in Adolescent and Young Adult Cannabis Users: Effects Moderated by Sex and Aerobic Fitness

Published online by Cambridge University Press:  15 July 2021

Ryan M. Sullivan Open the ORCID record for Ryan M. Sullivan [Opens in a new window] ,
Alexander L. Wallace Open the ORCID record for Alexander L. Wallace [Opens in a new window] ,
Natasha E. Wade Open the ORCID record for Natasha E. Wade [Opens in a new window] ,
Ann M. Swartz  and
Krista M. Lisdahl
Ryan M. Sullivan
Affiliation:
Department of Psychology, University of Wisconsin-Milwaukee, 2441 E Hartford Avenue, Milwaukee, WI53211, USA
Alexander L. Wallace
Affiliation:
Department of Psychology, University of Wisconsin-Milwaukee, 2441 E Hartford Avenue, Milwaukee, WI53211, USA
Natasha E. Wade
Affiliation:
Department of Psychiatry, UC San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA92093, USA
Ann M. Swartz
Affiliation:
Department of Kinesiology, University of Wisconsin-Milwaukee, 2400 E Hartford Avenue, Milwaukee, WI53211, USA
Krista M. Lisdahl*
Affiliation:
Department of Psychology, University of Wisconsin-Milwaukee, 2441 E Hartford Avenue, Milwaukee, WI53211, USA
*
*Correspondence and reprint requests to: Krista M. Lisdahl, Department of Psychology, University of Wisconsin-Milwaukee, 2441 East Hartford Ave, Milwaukee, WI 53211, USA. Phone: +1 414-229-7159; Fax: +1 414-229-5219. E-mail: [email protected]
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Abstract

Objectives:

Studies examining the impact of adolescent and young adult cannabis use on structural outcomes have been heterogeneous. One already-identified moderator is sex, while a novel potential moderator is extent of aerobic fitness. Here, we sought to investigate the associations of cannabis use, sex, and aerobic fitness levels on brain volume. Second, we explored brain–behavior relationships to interpret these findings.

Methods:

Seventy-four adolescents and young adults (36 cannabis users and 38 controls) underwent 3 weeks of monitored cannabis abstinence, aerobic fitness testing, structural neuroimaging, and neuropsychological testing. Linear regressions examined cannabis use and its interaction with sex and aerobic fitness on whole-brain cortical volume and subcortical regions of interests.

Results:

No main-effect differences between cannabis users and nonusers were observed; however, cannabis-by-sex interactions identified differences in frontal, temporal, and paracentral volumes. Female cannabis users generally exhibited greater volume while male users exhibited less volume compared to same-sex controls. Positive associations between aerobic fitness and frontal, parietal, cerebellum, and caudate volumes were observed. Cannabis-by-fitness interaction was linked with left superior temporal volume. Preliminary brain–behavior correlations revealed that abnormal volumes were not advantageous in either male or female cannabis users.

Conclusions:

Aerobic fitness was linked with greater brain volume and sex moderated the effect of cannabis use on volume; preliminary brain–behavior correlations revealed that differences in cannabis users were not linked with advantageous cognitive performance. Implications of sex-specific subtleties and mechanisms of aerobic fitness require large-scale investigation. Furthermore, present findings and prior literature on aerobic exercise warrant examinations of aerobic fitness interventions that aimed at improving neurocognitive health in substance-using youth.

Keywords

CannabisPhysical fitnessSex factorsGray matterNeuroimagingMarijuana use
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 27 , Special Issue 6: Clarifying the Complexities of Cannabis and Cognition , July 2021 , pp. 607 - 620
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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