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Two-year outcomes of moderately hypofractionated 70 Gy in 28 fractions, intensity-modulated radiotherapy and volumetric modulated arc therapy for localised prostate cancer

Published online by Cambridge University Press:  15 April 2020

Cindy Sharon Ortiz Arce ,
Cristian Salvador Leon Solorio ,
David Calderon Mendoza ,
Jose de Jesus Ornelas Lopez ,
Ana Luisa Nava Sierra ,
Placido Domingo Esqueda Guerrero ,
Rosalia Souto del Bosque ,
Alejandro Rodríguez Camacho ,
Jose Alais Cruz Cruz  and
Juan Antonio Reyes Nava
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Cindy Sharon Ortiz Arce
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Cristian Salvador Leon Solorio
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
David Calderon Mendoza
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Jose de Jesus Ornelas Lopez
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Ana Luisa Nava Sierra
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Placido Domingo Esqueda Guerrero
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Rosalia Souto del Bosque
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Alejandro Rodríguez Camacho
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Medical Center XXI Century, Ciudad de Mexico37160, Mexico
Jose Alais Cruz Cruz
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Juan Antonio Reyes Nava
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
Alejandro Olmos Guzman*
Affiliation:
Radiotherapy service, Mexican Social Security Institute, Bajio High Specialty Hospital, Ciudad de Mexico, Mexico
*
Author for correspondence: Alejandro Olmos Guzman, Radiotherapy department, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. Tel: 5531075073. E-mail: [email protected]
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Abstract

Introduction:

Standard external beam radiotherapy is a treatment option for patients with localised prostate cancer and is used in patients with low-, intermediate- and high-risk disease with androgen deprivation according to the risk of the disease. In the last few years, hypofractionated radiotherapy has been demonstrated to be as safe as standard radiotherapy if given over a shorter time than standard radiotherapy with larger doses per fraction. External radiotherapy for localised prostate cancer typically delivers 37–42 fractions of 1·8–2·0 Gy per fraction given 5 days per week over 7·5–8·5 weeks. Hypofractionated radiotherapy delivers 20–28 fractions of 2·5–2·6 Gy per fraction given 5 days per week over 4–5·6 weeks.

Methods:

A retrospective analysis of assessment of 30 patients was undertaken from 2016 to 2018. The aim of this study was to evaluate the 2-year outcomes of 30 patients with prostate cancer treated with hypofractionated radiotherapy 70 Gy in 28 fractions.

Results:

Biochemical failure with hypofractionated radiotherapy was found in a total of 20% of patients. In the classification by risk groups, there were no biochemical failures in low-risk patients; in the low intermediate course, 3·3% of patients; in the high intermediate group, 3·3% patients; and in the high-risk group, the largest documented biochemical failure was in 13·3% of patients. For acute urinary toxicity, grade I was 56·6%; grade II, 6·6%. For acute rectal toxicity, grade I was 46·6%; grade II, 3·3%.

Conclusion:

This is one of the first studies of hypofractionated radiotherapy in prostate cancer in Latin America, and the results of this study demonstrated that the outcomes were similar to the standard regimen in all risk groups.

Keywords

biochemical failurehypofractionatedprostate cancer
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 2 , June 2021 , pp. 242 - 244
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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