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Stereotactic radiotherapy of orbital metastasis from malignant melanoma: a case study

Published online by Cambridge University Press:  21 November 2014

Wojciech Majewski ,
Jerzy Wydmanski  and
Wojciech Rokicki
Wojciech Majewski*
Affiliation:
Department of Radiotherapy, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland
Jerzy Wydmanski
Affiliation:
Department of Radiotherapy, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland
Wojciech Rokicki
Affiliation:
Department and Clinic of Ophtalmology, Medical University of Silesia, Katowice, Poland
*
Correspondence to: Wojciech Majewski, Department of Radiotherapy, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeze Armii Krajowej 15, 44-100 Gliwice, Poland. Tel: +48 2 2788001. E-mail: [email protected]
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Abstract

Objective:

Orbital metastases lead to many distressful symptoms.

Methods:

A case-report of a 44-year-old woman with a melanoma metastasis in the orbital cavity, is reported. A patient presented with headache, proptosis and diplopia. The stereotactic radiotherapy of 19.5 Gy in three fractions using CyberKnife was performed. Follow-up examination 7 months later revealed satisfactory local control of the tumour, alleviation of orbital symptoms with no negative impact on visual function.

Conclusion:

Stereotactic radiotherapy seems to be a safe and effective treatment of orbital metastases from melanoma.

Keywords

CyberKnifemalignant melanomaorbital metastasisstereotactic radiotherapy
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 2 , June 2015 , pp. 208 - 211
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Copyright
© Cambridge University Press 2014 

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References

1.Tarhini, A A, Agarwala, S. Management of brain metastases in patients with melanoma. Curr Opin Oncol 2004; 16: 161–166.Google Scholar
2.Char, D H, Miller, T, Kroll, S. Orbital metastases: diagnosis and course. Br J Ophthalmol 1997; 81: 386–390.Google Scholar
3.Rosenberg, C, Finger, P T. Cutaneous malignant melanoma metastatic to the eye, lids and orbit. Surv Ophthalmol 2008; 53: 187–202.CrossRefGoogle Scholar
4.Zografos, L, Ducrey, N, Beati, Det al. Metastatic melanoma in the eye and orbit. Ophthalmology 2003; 110: 2245–2256.Google Scholar
5.Calcerrada, D-S N, Blasco Amaro, J A, Cardiel, C A, Andradas Aragones, A. The safety and efficacy of robotic image-guided radiosurgery system treatment for intra- and extracranial lesions: a systemic review of the literature. Radiother Oncol 2008; 89: 245–253.Google Scholar
6.Powell, J W, Chung, C T, Shah, H Ret al. Gamma Knife surgery in the management of radioresistant brain metastases in high-risk patients with melanoma, renal cell carcinoma, and sarcoma. J Neurosurg 2008; 109: 122–128.Google Scholar
7.Stinauer, M A, Kavanagh, B D, Schefter, T Eet al. Stereotactic body radiation therapy for melanoma and renal cell carcinoma: impact of single fraction equivalent dose on local control. Radiat Oncol 2011; 6: 34.Google Scholar
8.Sambade, M J, Peters, E C, Thomas, N E, Kaufmann, W K, Kimple, R J, Shields, J M. Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032. Radiother Oncol 2011; 98: 394–399.Google Scholar
9.Klingenstein, A, Kufeld, M, Wowra, B, Muracevic, A, Furweger, C, Schaler, U C. CyberKnife radiosurgery for the treatment of orbital metastases. Technol Cancer Res Treat 2012; 11: 433–439.Google Scholar
10.Adler, J R, Gibbs, I C, Putaweepong, P, Chang, S D. Visual field preservation after multisession CyberKnife radiosurgery for perioptic lesions. Neurosurgery 2006; 59: 244–254.Google Scholar