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Response to concurrent cetuximab: radiotherapy following failure of platinum-based induction chemotherapy in squamous cell carcinoma of the larynx

Published online by Cambridge University Press:  22 April 2013

L. Pettit  and
P. Ramachandra
L. Pettit*
Affiliation:
Deansley Centre, Royal Wolverhampton Hospital, Wolverhampton, UK
P. Ramachandra
Affiliation:
Deansley Centre, Royal Wolverhampton Hospital, Wolverhampton, UK
*
Correspondence to: Dr Laura Pettit, Hall-Edwards Research Radiotherapy Group, Queen Elizabeth Hospital, Birmingham, UK. Tel: +44 (0) 7779089066. E-mail: [email protected]
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Abstract

Concurrent chemoradiation is the standard of care in the non-surgical management of locally advanced squamous cell carcinoma (SCC) of the larynx. Cetuximab can be used as an alternative to platinum for concomitant radiotherapy and the addition of cetuximab to cisplatin has been reported to improve response rates compared with cisplatin alone. We report two cases of patients who progressed through platinum-based induction chemotherapy and subsequently achieved a complete response with concurrent cetuximab radiotherapy.

Keywords

cetuximabchemoradiationsquamous cell carcinoma of the head and neck
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 13 , Issue 1 , March 2014 , pp. 93 - 97
Copyright
Copyright © Cambridge University Press 2013 

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