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A new approach to cancer treatment*

Published online by Cambridge University Press:  08 December 2014

Syed F. Akber
Syed F. Akber*
Affiliation:
Consulting Physicist, Lorain, OH, USA
*
Correspondence to: Syed Farooq Akber, Consulting Physicist, Lorain, OH 44053, USA. Tel: 440-781-0842; E-mail: [email protected]
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Abstract

A new approach is applied to correlate different phases of the HeLa cell S-3 with mean lethal ionising radiation dose (Do) along with nuclear magnetic resonance water-proton spin-lattice relaxation time (T1). This information can be used to pin-point the mitotic phase of the cells in vivo. This enables us to apply ionising radiation treatment at that particular time. This will increase the efficacy of radiation treatment in cancer patients.

Keywords

T1DoHela cellscell cyclecancer
Type
Technical Note
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 1 , March 2015 , pp. 99 - 101
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Copyright
© Cambridge University Press 2014 

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Footnotes

*

Paper presented at the 56th Annual Meeting of the American Association of Physicists in Medicine, Austin, Texas, 19–24 July 2014.

References

1.Beall, P T, Hazlewood, C F, Rao, P N. Nuclear magnetic resonance patterns of intracellular water of HeLa cell cycle. Science 1976; 192: 904–907.CrossRefGoogle ScholarPubMed
2.Terasima, T, Tolmach, T J. Variations in several responses of Hela cells to x-irradiation during the division cycle. Biophys J 1963; 3: 11–32.CrossRefGoogle ScholarPubMed
3.Terasima, T, Tolmach, T J. Changes in x-ray sensitivity of HeLa cells during the division cycle. Nature 1961; 190: 1210–1211.CrossRefGoogle ScholarPubMed
4.Terasima, T, Tolmach, T J. X-ray sensitivity and DNA synthesis in synchronous population of HeLa cells. Science 1963; 140: 490–492.CrossRefGoogle ScholarPubMed
5.Sapozink, M D. Oxygen enhancement ratios in synchronous HeLa cells exposed to low-LET radiation. Radiat Res 1977; 69: 27–39.CrossRefGoogle ScholarPubMed
6.Akber, S F. Oxygen in S phase of a cell cycle. J Radiother Pract 2013; 12: 360–362.CrossRefGoogle Scholar