Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-23T08:28:17.005Z Has data issue: false hasContentIssue false
  • English
  • Français

Dosimetric comparison of different radiotherapy techniques for the treatment of Retinoblastoma

Published online by Cambridge University Press:  26 November 2020

Jyotiman Nath Open the ORCID record for Jyotiman Nath [Opens in a new window] ,
Pranjal Goswami Open the ORCID record for Pranjal Goswami [Opens in a new window] ,
Partha Pratim Medhi Open the ORCID record for Partha Pratim Medhi [Opens in a new window] ,
Gautam Sarma Open the ORCID record for Gautam Sarma [Opens in a new window] ,
Apurba Kumar Kalita Open the ORCID record for Apurba Kumar Kalita [Opens in a new window]  and
Mouchumee Bhattacharyya Open the ORCID record for Mouchumee Bhattacharyya [Opens in a new window]
Jyotiman Nath
Affiliation:
Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam, 781016, India
Pranjal Goswami
Affiliation:
Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam, 781016, India
Partha Pratim Medhi
Affiliation:
Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam, 781016, India
Gautam Sarma*
Affiliation:
Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam, 781016, India
Apurba Kumar Kalita
Affiliation:
Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam, 781016, India
Mouchumee Bhattacharyya
Affiliation:
Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam, 781016, India
*
Author for correspondence: Dr Gautam Sarma, Assistant Professor, Department of Radiation Oncology, Dr B Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam781016, India. Tel: +9678845070. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Aim:

This study aims to compare the dosimetric parameters among four different external beam radiotherapy techniques used for the treatment of retinoblastoma.

Materials and methods:

Computed tomography (CT) sets of five retinoblastoma patients who required radiotherapy to one globe were included. Four different plans were generated for each patient using three dimensional conformal radiotherapy (3DCRT), intensity modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT) and VMAT using flattening filter free (VMAT-FFF) beam techniques. Plans were compared for target coverage and organs at risk (OARs) sparing.

Results:

The target coverage of planning target volume (PTV) for all the four modalities were clinically acceptable with a V95 of 95 ± 0%, 97·6 ± 1·87%, 99·3 ± 0·5% and 99·17 ± 0·45% for 3DCRT, IMRT, VMAT and VMAT-FFF respectively. The VMAT and IMRT plans had better target coverage than the 3DCRT plans (p = 0·001 and p = 0·07 respectively). IMRT and VMAT plans were also found superior to 3DCRT plans in terms of OAR sparing like brainstem, optic chiasm, brain (p < 0·05). VMAT delivered significantly lower dose to the brainstem and contralateral optic nerve in comparison to IMRT. Use of VMAT-FFF beams did not show any benefit over VMAT in target coverage and OAR sparing.

Conclusion:

VMAT should be preferred over 3DCRT and IMRT for treatment of retinoblastoma owing to better target coverage and less dose to most of the OARs. However, IMRT and VMAT should be used with caution because of the increased low dose volumes to the OARs like contralateral lens and eyeball.

Keywords

retinoblastomaradiotherapy3DCRTIMRTVMAT
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 2 , June 2022 , pp. 159 - 164
Check for updates
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Houston, SK, Murray, TG, Wolfe, SQ, Fernandes, CE. Current update on retinoblastoma. Int Ophthalmol Clin 2011; 51: 77–91.CrossRefGoogle ScholarPubMed
Kivelä, T. The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br J Ophthalmol 2009; 93: 1129–1131.CrossRefGoogle ScholarPubMed
Agarwal, A, Thaker, N, Tawk, B et al. The evolution of radiation therapy for retinoblastoma: the MD Anderson Cancer Center Experience. Int J Part Ther 2016; 2 (4): 490–498.CrossRefGoogle ScholarPubMed
Ayari-Jeridi, H, Moran, K, Chebbi, A et al. Mutation spectrum of RB1 gene in unilateral retinoblastoma cases from Tunisia and correlations with clinical features. PLoS One 2015; 10: e0116615.CrossRefGoogle ScholarPubMed
Hamel, P, Heon, E, Gallie, B, Budning, A. Focal therapy in the management of retinoblastoma: when to start and when to stop. J Am Assoc Pediatr Ophthalmol Strabismus 2000; 4 (6): 334–337.CrossRefGoogle Scholar
Abramson, D, Ellsworth, R, Rozakis, G. Cryotherapy for retinoblastoma. Arch Ophthalmol 1982; 100 (8): 1253–1256.CrossRefGoogle ScholarPubMed
Shields, C, Shields, J, De Potter, P et al. Plaque radiotherapy in the management of retinoblastoma. Ophthalmology 1993; 100 (2): 216–224.CrossRefGoogle ScholarPubMed
Shields, C. Plaque radiotherapy for retinoblastoma Long-term tumor control and treatment complications in 208 tumors. Ophthalmology 2001; 108 (11): 2116–2121.CrossRefGoogle ScholarPubMed
Friedman, D, Himelstein, B, Shields, C et al. Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma. J Clin Oncol 2000; 18 (1): 12.CrossRefGoogle ScholarPubMed
Reddy, P. Role of external beam radiotherapy in management of retinoblastoma – a review article. Adv Ophthalmol Vis Syst 2017; 7 (6): 420–424.Google Scholar
Temming, P, Arendt, M, Viehmann, A et al. Incidence of second cancers after radiotherapy and systemic chemotherapy in heritable retinoblastoma survivors: a report from the German reference center. Pediatr Blood Cancer 2016; 64 (1): 71–80.CrossRefGoogle ScholarPubMed
Jairam, V, Roberts, K, Yu, J. Historical trends in the use of radiation therapy for pediatric cancers: 1973-2008. Int J Radiat Oncol Biol Phys 2013; 85 (3): e151–e155.CrossRefGoogle ScholarPubMed
Munier, F, Verwey, J, Pica, A et al. New developments in external beam radiotherapy for retinoblastoma: from lens to normal tissue-sparing techniques. Clin Exp Ophthalmol 2008; 36 (1): 78–89.CrossRefGoogle ScholarPubMed
Kim, J, Park, Y. Treatment of retinoblastoma: the role of external beam radiotherapy. Yonsei Med J 2015; 56 (6): 1478–1491.CrossRefGoogle ScholarPubMed
Jin, X, Yi, J, Zhou, Y, Yan, H, Han, C, Xie, C. Comparison of whole-field simultaneous integrated boost VMAT and IMRT in the treatment of nasopharyngeal cancer. Med Dosim 2013; 38 (4): 418–23.CrossRefGoogle ScholarPubMed
Wu, Z, Xie, C, Hu, M et al. Dosimetric benefits of IMRT and VMAT in the treatment of middle thoracic esophageal cancer: is the conformal radiotherapy still an alternative option? J Appl Clin Med Phys 2014; 15 (3): 93–101.CrossRefGoogle ScholarPubMed
Palma, D, Vollans, E, James, K et al. Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2008; 72 (4): 996–1001.CrossRefGoogle ScholarPubMed
Otto, K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008; 35 (1): 310–317.CrossRefGoogle Scholar
Iori, M, Cattaneo, G, Cagni, E et al. Dose–volume and biological-model based comparison between helical tomotherapy and (inverse-planned) IMAT for prostate tumours. Radiother Oncol 2008; 88 (1): 34–45.CrossRefGoogle ScholarPubMed
Deng, Z, Shen, L, Zheng, X et al. Dosimetric advantage of volumetric modulated arc therapy in the treatment of intraocular cancer. Radiat Oncol 2017; 12 (1): 1–7.CrossRefGoogle ScholarPubMed
Shaw, E, Kline, R, Gillin, M et al. Radiation therapy oncology group: radiosurgery quality assurance guidelines. Int J Radiat Oncol Biol Phys 1993; 27 (5): 1231–1239.CrossRefGoogle ScholarPubMed
Atiq, M, Atiq, A, Iqbal, K, Shamsi, Q, Andleeb, F, Buzdar, S. Evaluation of dose conformity and coverage of target volume for intensity-modulated radiotherapy of pelvic cancer treatment. Indian J Cancer 2017; 54 (1): 379–384.CrossRefGoogle ScholarPubMed
Eldebawy, E, Parker, W, Abdel Rahman, W, Freeman, C. Dosimetric study of current treatment options for radiotherapy in retinoblastoma. Int J Radiat Oncol Biol Phys 2012; 82 (3): e501–e505.CrossRefGoogle ScholarPubMed
Vanetti, E, Clivio, A, Nicolini, G et al. Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx and larynx: a treatment planning comparison with fixed field IMRT. Radiother Oncol 2009; 92 (1): 111–117.CrossRefGoogle ScholarPubMed
Bertelsen, A, Hansen, C, Johansen, J, Brink, C. Single arc volumetric modulated arc therapy of head and neck cancer. Radiother Oncol 2010; 95 (2): 142–148.CrossRefGoogle ScholarPubMed
Hall, E. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys. 2006; 65 (1): 1–7.CrossRefGoogle ScholarPubMed