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Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Published online by Cambridge University Press:  25 February 2010

Jeremy P. Appleton  and
Peter Bridge
Jeremy P. Appleton
Affiliation:
Radiotherapy Department, North Wales Cancer Treatment Centre, Ysbyty Glan Clwyd, Rhyl, Denbighshire, UK
Peter Bridge
Affiliation:
Radiotherapy and Oncology, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK
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Abstract

The aims of conservative treatment in patients with ocular melanoma are globe retention, good visual acuity (VA) and local control. Two well-established radiation conservative treatment options are proton beam radiotherapy and episcleral plaque brachytherapy (EPB). Patients who receive treatment with either of these options will experience some degree of radiation-related ocular complications and poor VA. The purpose of this review of the literature is to establish whether there is a significant clinical difference in normal tissue morbidity and local tumour control between proton therapy and EPB, and whether this difference can justify the purchase and implementation of additional proton therapy facilities. Based on this review, evidence suggested that both treatment options are comparable, and that neither proton therapy nor EPB is clinically superior than the other regarding normal tissue morbidity and local tumour control. This review highlighted the need for further research on a larger scale in order to bridge the gap that is apparent within the literature.

Keywords

Ocular melanomabrachytherapyproton therapychoroidal melanoma
Type
Literature Review
Information
Journal of Radiotherapy in Practice , Volume 9 , Issue 1 , March 2010 , pp. 53 - 61
Copyright
Copyright © Cambridge University Press 2010

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References

Bomford, CK, Kunkler, IH. Walter and Miller’s textbook of radiotherapy. 6th edition. Churchill Livingstone, 2004.Google Scholar
Wöll, E, Bedikian, A, Legha, SS. Uveal melanoma: natural history and treatment options for metastatic disease. Melanoma Res 1999; 9: 575–581.CrossRefGoogle ScholarPubMed
Souhami, R, Tobias, J. Cancer and its management. 5th edition. Blackwell, 2005.CrossRefGoogle Scholar
Sagerman, RH, Alberti, WE. Radiotherapy of intraocular and orbital tumours. 2nd edition. New York: Springer, 2003.CrossRefGoogle Scholar
Wilson, MW, Hungerford, JL. Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma. Ophthalmology 1999; 106: 1579–1587.CrossRefGoogle ScholarPubMed
Munzenrider, JE. Uveal melanomas. Conservation treatment. Hematol Oncol Clin North Am 2001; 15: 389–402.CrossRefGoogle ScholarPubMed
Munzenrider, JE, Szechter, A. Palladium-103 plaque radiotherapy for choroidal melanoma: Results of a 7-year study. Ophthalmology 1999; 106: 606–613.Google Scholar
Melia, M, Moy, CS, Reynolds, SM, Hayman, JA, Murray, TG, Hovland, KR, Earle, JD, Kurinij, N, Dong, LM, Miskala, PH, Fountain, C, Cella, D, Mangione, CM; Collaborative Ocular Melanoma Study-Quality of Life Study Group. Quality of life after iodine 125 brachytherapy vs enucleation for choroidal melanoma: 5-year results from the Collaborative Ocular Melanoma Study: COMS QOLS Report No. 3. Arch Ophthalmol 2006; 124: 226–238.Google Scholar
Regillo, CD, Brown, GC, Flynn, HW. Vitreoretinal disease: The essentials. Germany: Thieme Medical Publishers, 1999.Google Scholar
Damato, B, Kacperek, A, Chopra, M, Campbell, IR, Errington, RD. Proton beam radiotherapy of choroidal melanoma: The Liverpool-Clatterbridge experience. Int J Radiat Oncol Biol Phys 2005; 62: 1405–1411.Google Scholar
Damato, B, Patel, I, Campbell, IR, Mayles, HM, Errington, RD. Local tumor control after 106Ru brachytherapy of choroidal melanoma. Int J Radiat Oncol Biol Phys 2005; 63: 385–391.Google Scholar
Fuss, M, Loredo, LN, Blacharski, PA, Grove, RI, Slater, JD. Proton radiation therapy for medium and large choroidal melanoma: Preservation of the eye and its functionality. Int J Radiat Oncol Biol Phys 2001; 49: 1053–1059.Google Scholar
Gündüz, K, Shields, CL, Shields, JA, Cater, J, Freire, JE, Brady, LW. Radiation complications and tumor control after plaque radiotherapy of choroidal melanoma with macular involvement. Am J Ophthalmol 1999; 127: 579–589.Google Scholar
Thornton, AF, Fitzek, M, Klein, S, Dickey, E, Sullivan, MB, O’Ryan-Blair, A, Schreuder, N, Allgower, C, Mascia, A, Farr, J, Cameron, J. Proton beam radiotherapy: A specialized treatment alternative. Community Oncol 2007; 4: 599–606.CrossRefGoogle Scholar
PHRU (2008) CASP Appraisal Tools. http://www.phru.nhs.uk/Pages/PHD/resources.htm.Google Scholar
Dawson, E, Sagoo, MS, Mehta, JS, Comer, R, Hungerford, J, Lee, J. Strabismus in adults with uveal melanoma following episcleral plaque brachytherapy. J AAPOS 2007; 11: 584–588.Google Scholar
Dendale, R, Lumbroso-Le Rouic, L, Noel, G, Feuvret, L, Levy, C, Delacroix, S, Meyer, A, Nauraye, C, Mazal, A, Mammar, H, Garcia, P, D'Hermies, F, Frau, E, Plancher, C, Asselain, B, Schlienger, P, Mazeron, JJ, Desjardins, L. Proton beam radiotherapy for uveal melanoma: Results of Curie Institut-Orsay proton therapy center (ICPO). Int J Radiat Oncol Biol Phys 2006; 65: 780–787.Google Scholar
Finger, PT. Radiation therapy for choroidal melanoma. Surv Ophthalmol 1997; 42: 215–232.Google Scholar
Anderson, DM, Keith, J, Novak, PD. Mosby's Medical, Nursing, & Allied Health Dictionary, 6th edn. London: Mosby, 2002.Google Scholar
Conway, RM, Poothullil, AM, Daftari, IK, Weinberg, V, Chung, JE, O'Brien, JM. Estimates of ocular and visual retention following treatment of extra-large uveal melanomas by proton beam radiotherapy. Arch Ophthalmol 2006; 124: 838–843.CrossRefGoogle ScholarPubMed
Jensen, AW, Petersen, IA, Kline, RW, Stafford, SL, Schomberg, PJ, Robertson, DM. Radiation complications and tumor control after 125I plaque brachytherapy for ocular melanoma. Int J Radiat Oncol Biol Phys 2005; 63: 101–108.Google Scholar
Cocchiarella, L. Guides to the evaluation of permanent impairment: Text revision. 5th edition. American Medical Association, 2002.Google Scholar
MDSUPPORT.ORG (2009) Snellen Chart. http://www.mdsupport.org/snellen.html.Google Scholar
UNIROMA (2009) Bailey Lovie Chart. www.uniroma2.it/otticafp/va.html.Google Scholar
Collaborative ocular melanoma study (COMS) randomized trial of I-125 brachytherapy for medium choroidal melanoma. I. visual acuity after 3 years COMS report no. 16. Ophthalmology 2001; 108: 348–366.CrossRefGoogle Scholar
The Collaborative Ocular Melanoma Study - www.jhu.edu/wctb/coms/.Google Scholar
Lumbroso-Le Rouic, L, Charif Chefchaouni, M, Levy, C, Plancher, C, Dendale, R, Asselain, B, Solignac, S, Mazal, A, Desjardins, L. 125I plaque brachytherapy for anterior uveal melanomas. Eye 2004; 18: 911–916.CrossRefGoogle ScholarPubMed
Sagoo, MS, Shields, CL, Mashayekhi, A, Freire, J, Emrich, J, Reiff, J, Komarnicky, L, Shields, JA. Plaque radiotherapy for choroidal melanoma encircling the optic disc (circumpapillary choroidal melanoma). Arch Ophthalmol 2007; 125: 1202–1209.Google Scholar
Courdi, A, Caujolle, JP, Grange, JD, Diallo-Rosier, L, Sahel, J, Bacin, F, Zur, C, Gastaud, P, Iborra-Brassart, N, Hérault, J, Chauvel, P. Results of proton therapy of uveal melanomas treated in Nice. Int J Radiat Oncol Biol Phys 1999; 45: 5–11.Google Scholar
Shields, CL, Naseripour, M, Cater, J, Shields, JA, Demirci, H, Youseff, A, Freire, J. Plaque radiotherapy for large posterior uveal melanomas (>or = 8-mm thick) in 354 consecutive patients. Ophthalmology 2002; 109: 1838–1849.Google Scholar
Gragoudas, ES, Lane, AM, Munzenrider, J, Egan, KM, Li, W. Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma. Trans Am Ophthalmol Soc 2002; 100: 43–48; discussion 48–49.Google Scholar
Egger, E, Zografos, L, Schalenbourg, A, Beati, D, Böhringer, T, Chamot, L, Goitein, G. Eye retention after proton beam radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys 2003; 55: 867–880.Google Scholar
Finger, PT, Berson, A, Ng, T, Szechter, A. Palladium-103 plaque radiotherapy for choroidal melanoma: an 11-year study. Int J Radiat Oncol Biol Phys 2002; 54: 1438–1445.Google Scholar
Katvat, A, Duzenli, C, Ma, R, Paton, K, Pickles, T. The treatment of choroidal melanoma with 198Au plaque brachytherapy. Radiother Oncol 2001; 59: 153–156.Google Scholar
Rouberol, F, Roy, P, Kodjikian, L, Gérard, JP, Jean-Louis, B, Grange, JD. Survival, anatomic, and functional long-term results in choroidal and ciliary body melanoma after ruthenium brachytherapy (15 years’ experience with beta-rays). Am J Ophthalmol 2004; 137: 893–900.CrossRefGoogle ScholarPubMed
Sia, S, Harper, C, McAllister, I, Perry, A. Iodine-I25 episcleral plaque therapy in uveal melanoma. Clin Experiment Ophthalmol 2000; 28: 409–413.Google Scholar
Höcht, S, Bechrakis, NE, Nausner, M, Kreusel, KM, Kluge, H, Heese, J, Heufelder, J, Cordini, D, Homeyer, H, Fuchs, H, Martus, P, Foerster, MH, Wiegel, T, Hinkelbein, W. Proton therapy of uveal melanomas in Berlin. 5 years of experience at the Hahn-Meitner Institute. Strahlenther Onkol 2004; 180: 419–424.CrossRefGoogle ScholarPubMed
Egger, E, Schalenbourg, A, Zografos, L, Bercher, L, Boehringer, T, Chamot, L, Goitein, G. Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys 2001; 51: 138–147.CrossRefGoogle ScholarPubMed
Particle Therapy Co-Operative Group - http://ptcog.web.psi.ch/ptcentres.Google Scholar
Boyd, SR, Gittos, A, Richter, M, Hungerford, JL, Errington, RD, Cree, IA. Proton beam therapy and iris neovascularisation in uveal melanoma. Eye 2006; 20: 832–836.Google Scholar
Yock, TI, Tarbell, NJ. Technology insight: Proton beam radiotherapy for treatment in pediatric brain tumors. Nat Clin Pract Oncol 2004; 1: 97–103; quiz 1 p following 111.CrossRefGoogle ScholarPubMed
Landwehr, G, Umbach, E, Haase, A. Rontgen centennial: X-rays in natural and life sciences. Singapore: World Scientific, 1997.Google Scholar
Albert, DM, Polans, A. Ocular oncology. New York: Marcel Dekker, 2003.Google Scholar
Delvin, PM. Brachytherapy applications and techniques. Lippincott Williams and Wilkins: Philadelphia, 2006.Google Scholar
Augsburger, JJ. Is observation really appropriate for small choroidal melanomas. Trans Am Ophthalmol Soc 1993; 91: 147–68; discussion 169.Google Scholar
Seregard, S, Landau, I. Transpupillary thermotherapy as an adjunct to ruthenium plaque radiotherapy for choroidal melanoma. Acta Ophthalmol Scand 2001; 79: 19–22.Google Scholar
Char, DH, Miller, T, Crawford, JB. Uveal tumour resection. Br J Ophthalmol 2001; 85: 1213–1219.Google Scholar
Peyman, GA, Juarez, CP, Diamond, JG, Raichand, M. Ten years experience with eye wall resection for uveal malignant melanomas. Ophthalmology 1984; 91: 1720–1725.Google Scholar